KEGG PATHWAY: efus04622

KEGG

PATHWAY: efus04622

Entry

efus04622                   Pathway

Name

RIG-I-like receptor signaling pathway - Eptesicus fuscus (big brown bat)

Description

Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.

Class

Organismal Systems; Immune system

Pathway map

RIG-I-like receptor signaling pathway

Organism

Eptesicus fuscus (big brown bat) [GN:efus]

Gene

RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]

IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]

ZNFX1; NFX1-type zinc finger-containing protein 1 [KO:K27391]

MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]

DHX58; ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]

TRAF3; TNF receptor-associated factor 3 [KO:K03174]

TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]

AZI2; 5-azacytidine-induced protein 2 isoform X2 [KO:K12651]

TBKBP1; TANK-binding kinase 1-binding protein 1 [KO:K12652]

IKBKG; NF-kappa-B essential modulator [KO:K07210]

TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]

IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]

IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]

IRF7; interferon regulatory factor 7 [KO:K09447]

IFNB1; interferon beta [KO:K05415]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

interferon omega-2-like [KO:K05440]

IFNE; interferon epsilon [KO:K05442]

IFNK; interferon kappa [KO:K05441]

TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]

FADD; FAS-associated death domain protein [KO:K02373]

RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]

CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]

CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]

CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]

IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]

NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]

NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]

NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]

RELA; transcription factor p65 isoform X1 [KO:K04735]

TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]

MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]

TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]

MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]

MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]

MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]

MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]

MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]

MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]

MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]

MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]

interleukin-8-like [KO:K10030]

CXCL8; interleukin-8 [KO:K10030]

TNF; tumor necrosis factor isoform X1 [KO:K03156]

IL12A; interleukin-12 subunit alpha [KO:K05406]

IL12B; interleukin-12 subunit beta [KO:K05425]

CXCL10; C-X-C motif chemokine 10 [KO:K12671]

ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]

TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]

CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]

RNF125; E3 ubiquitin-protein ligase RNF125 isoform X1 [KO:K12170] [EC:2.3.2.27]

ISG15; ubiquitin-like protein ISG15 [KO:K12159]

ATG5; autophagy protein 5 isoform X1 [KO:K08339]

ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]

NLRX1; NLR family member X1 [KO:K12653]

STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]

OTUD5; OTU domain-containing protein 5 isoform X2 [KO:K12655] [EC:3.4.19.12]

SIKE1; suppressor of IKBKE 1 isoform X2 [KO:K12656]

DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]

PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1 [KO:K09578] [EC:5.2.1.8]

TKFC; triokinase/FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]

Compound

RNA

Reference

Authors

Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T

Title

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

Journal

Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087

Reference

Authors

Takeuchi O, Akira S

Title

MDA5/RIG-I and virus recognition.

Journal

Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002

Reference

Authors

Yoneyama M, Fujita T

Title

RNA recognition and signal transduction by RIG-I-like receptors.

Journal

Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x

Reference

Authors

Nakhaei P, Genin P, Civas A, Hiscott J

Title

RIG-I-like receptors: sensing and responding to RNA virus infection.

Journal

Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001

Reference

Authors

Moore CB, Ting JP

Title

Regulation of mitochondrial antiviral signaling pathways.

Journal

Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005

Reference

Authors

Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB

Title

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.

Journal

Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012

Reference

Authors

Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G

Title

Approaching the RNA ligand for RIG-I?

Journal

Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x

Reference

Authors

Saito T, Gale M Jr

Title

Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.

Journal

J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210

Reference

Authors

Kawai T, Akira S

Title

Toll-like receptor and RIG-I-like receptor signaling.

Journal

Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020

Reference

Authors

Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J

Title

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

Journal

Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013

Reference

Authors

Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T

Title

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.

Journal

J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200

Reference

Authors

Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR

Title

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

Journal

J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200

Reference

Authors

Liu G, Gack MU

Title

Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.

Journal

Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017

Related
pathway

MAPK signaling pathway

Ubiquitin mediated proteolysis

Apoptosis

JAK-STAT signaling pathway

KO pathway

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