KEGG   PATHWAY: efus04630
Entry
efus04630                   Pathway                                
Name
JAK-STAT signaling pathway - Eptesicus fuscus (big brown bat)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
efus04630  JAK-STAT signaling pathway
efus04630

Other DBs
GO: 0007259
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103287584  IL2; interleukin-2 [KO:K05429]
103290101  IL4; interleukin-4 [KO:K05430]
103283856  IL7; interleukin-7 isoform X1 [KO:K05431]
103289988  IL9; interleukin-9 [KO:K05432]
103288051  IL15; interleukin-15 isoform X1 [KO:K05433]
103287593  IL21; interleukin-21 [KO:K05434]
103288789  TSLP; thymic stromal lymphopoietin [KO:K05436]
103304881  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
103288895  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
103283323  METTL8; tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X1 [KO:K05070]
103304360  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
114226821  interleukin-4 receptor subunit alpha-like [KO:K05071]
114228405  LOW QUALITY PROTEIN: interleukin-4 receptor subunit alpha-like [KO:K05071]
103298082  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
103300821  LOW QUALITY PROTEIN: interleukin-9 receptor [KO:K05073]
103298583  IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074]
103300789  IL21R; interleukin-21 receptor [KO:K05075]
103304704  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
103286870  IL5; interleukin-5 [KO:K05428]
103286945  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
129150036  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
103300377  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
129150026  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
103304958  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
103288900  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
103292051  IL6; interleukin-6 [KO:K05405]
103304208  IL11; interleukin-11 [KO:K05417]
103290112  IL13; interleukin-13 [KO:K05435]
103300828  IL27; interleukin-27 subunit alpha [KO:K22629]
103286857  OSM; oncostatin-M [KO:K05418]
103287134  LIF; leukemia inhibitory factor [KO:K05419]
103292663  CNTF; ciliary neurotrophic factor isoform X2 [KO:K05420]
103296323  cardiotrophin-1-like isoform X1 [KO:K05422]
103290929  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
103299022  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
103303119  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
103286456  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
103299992  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
103299266  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
103301054  IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598]
103303118  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
103298835  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
103298816  LIFR; leukemia inhibitory factor receptor [KO:K05058]
103286463  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
103297476  IL10; interleukin-10 [KO:K05443]
103297557  IL19; interleukin-19 [KO:K05444]
103292516  IL22; interleukin-22 [KO:K05445]
103297555  IL20; interleukin-20 [KO:K22667]
103297551  IL24; interleukin-24 isoform X1 [KO:K22668]
103292515  IL26; interleukin-26 [KO:K05446]
103293746  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
103289929  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
103305259  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
103296262  IL20RB; LOW QUALITY PROTEIN: interleukin-20 receptor subunit beta [KO:K05137]
103292071  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
103285024  IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139]
103286786  IL12A; interleukin-12 subunit alpha [KO:K05406]
103291598  IL12B; interleukin-12 subunit beta [KO:K05425]
103292428  IL23A; interleukin-23 subunit alpha [KO:K05426]
103299579  IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063]
103284246  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
103284104  IL23R; interleukin-23 receptor [KO:K05065]
103285995  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
103293247  somatotropin [KO:K05438]
103290147  PRL; prolactin isoform X2 [KO:K05439]
103300654  THPO; thrombopoietin isoform X2 [KO:K06854]
103297192  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
103297344  LEP; leptin [KO:K05424]
103301161  EPOR; erythropoietin receptor [KO:K05079]
103298830  GHR; growth hormone receptor isoform X1 [KO:K05080]
103298098  PRLR; prolactin receptor isoform X1 [KO:K05081]
103294919  MPL; thrombopoietin receptor [KO:K05082]
103294880  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
103284097  LEPR; leptin receptor [KO:K05062]
103289195  IFNB1; interferon beta [KO:K05415]
103297388  IFNE; interferon epsilon [KO:K05442]
103297374  IFNK; interferon kappa [KO:K05441]
129147779  interferon lambda-3-like [KO:K22669]
103304876  interferon lambda-3-like [KO:K22669]
129151203  interferon lambda-3-like [KO:K22669]
129151204  interferon lambda-3-like [KO:K22669]
129151205  interferon lambda-3-like [KO:K22669]
129151206  interferon lambda-3-like [KO:K22669]
129151207  interferon lambda-3-like [KO:K22669]
103305022  interferon omega-2-like [KO:K05440]
129151656  interferon omega-2-like [KO:K05440]
129151661  interferon omega-2-like [KO:K05440]
129151662  interferon omega-2-like [KO:K05440]
129151664  interferon omega-2-like [KO:K05440]
129151665  interferon omega-2-like [KO:K05440]
129151666  interferon omega-2-like [KO:K05440]
129151668  interferon omega-2-like [KO:K05440]
129151669  interferon omega-2-like [KO:K05440]
129151670  interferon omega-2-like [KO:K05440]
129151671  interferon omega-2-like [KO:K05440]
103289928  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103289837  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103291945  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
103292513  IFNG; interferon gamma [KO:K04687]
103285013  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103289926  IFNGR2; interferon gamma receptor 2 [KO:K05133]
114234667  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103299170  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103288853  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
103294241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103284970  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103295746  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103284092  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103289149  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
103299558  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
103301133  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
103290572  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103292429  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103293093  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
103290571  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
103293234  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
103293235  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
103292452  STAT6; signal transducer and activator of transcription 6 isoform X2 [KO:K11225]
103301487  IRF9; interferon regulatory factor 9 [KO:K04693]
103298501  CISH; cytokine-inducible SH2-containing protein [KO:K04701]
103286112  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
103288046  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
103298250  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
103283718  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
103305417  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
103297115  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
103303533  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
103303728  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
103298971  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
103285583  BCL2L1; bcl-2-like protein 1 [KO:K04570]
103295567  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
103292358  MYC; myc proto-oncogene protein [KO:K04377]
103290903  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103288032  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103301919  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103295571  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103290551  aldehyde oxidase 4-like isoform X1 [KO:K00157] [EC:1.2.3.1]
103290620  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
103290550  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
103293019  GFAP; glial fibrillary acidic protein isoform X2 [KO:K05640]
103292590  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
103283524  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
103302561  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X2 [KO:K18026] [EC:3.1.3.48]
103289036  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
103286158  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
103288832  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
103283780  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
103301009  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
103292922  LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS2-like [KO:K16063] [EC:2.3.2.-]
103296528  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X2 [KO:K16064] [EC:2.3.2.-]
103294233  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
103302101  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
114229111  four and a half LIM domains protein 1-like [KO:K14365]
103287068  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
103298291  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103283761  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103305666  SOS1; son of sevenless homolog 1 [KO:K03099]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103299551  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103305161  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103294784  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103295323  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
efus04010  MAPK signaling pathway
efus04060  Cytokine-cytokine receptor interaction
efus04110  Cell cycle
efus04120  Ubiquitin mediated proteolysis
efus04151  PI3K-Akt signaling pathway
efus04210  Apoptosis
KO pathway
ko04630   
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