KEGG   PATHWAY: efus04210
Entry
efus04210                   Pathway                                
Name
Apoptosis - Eptesicus fuscus (big brown bat)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
efus04210  Apoptosis
efus04210

Other DBs
GO: 0006915
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103286737  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103295138  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722]
103289966  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103296397  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103291049  FADD; FAS-associated death domain protein [KO:K02373]
103300478  TNF; tumor necrosis factor isoform X1 [KO:K03156]
103289002  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103284564  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103290542  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
103290541  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103290617  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
129150692  caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
129150695  caspase-6-like [KO:K04396] [EC:3.4.22.59]
103295435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103288572  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
103303807  BID; BH3-interacting domain death agonist isoform X3 [KO:K04726]
103297647  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103303014  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103287023  DIABLO; diablo IAP-binding mitochondrial protein isoform X2 [KO:K10522]
103291643  SEPTIN4; septin-4 isoform X2 [KO:K16943]
103291391  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
103292869  cytochrome c-like [KO:K08738]
103291881  cytochrome c [KO:K08738]
103305670  cytochrome c-like [KO:K08738]
103303075  cytochrome c-like [KO:K08738]
129150288  cytochrome c-like [KO:K08738]
103300565  cytochrome c-like [KO:K08738]
103289111  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
103292032  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103289494  PRF1; perforin-1 [KO:K07818]
103296351  granzyme B-like [KO:K01353] [EC:3.4.21.79]
103296359  granzyme H-like [KO:K01353] [EC:3.4.21.79]
129149017  granzyme B-like isoform X1 [KO:K01353] [EC:3.4.21.79]
114229870  granzyme B-like [KO:K01353] [EC:3.4.21.79]
129147060  granzyme H-like [KO:K01353] [EC:3.4.21.79]
103285264  tubulin alpha-1A chain [KO:K07374]
103289293  TUBA4A; tubulin alpha-4A chain [KO:K07374]
103289950  tubulin alpha-1C chain [KO:K07374]
103292767  tubulin alpha-1C chain-like [KO:K07374]
103286986  tubulin alpha-3 chain [KO:K07374]
103289292  tubulin alpha-1D chain [KO:K07374]
103287202  tubulin alpha-3 chain [KO:K07374]
103285518  TUBA1C; tubulin alpha-1C chain [KO:K07374]
129149800  tubulin alpha-1B chain [KO:K07374]
103298570  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
103298971  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
103299154  ACTB; actin, cytoplasmic 1 [KO:K05692]
103298235  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103296044  SPTAN1; spectrin alpha chain, non-erythrocytic 1 [KO:K06114]
103298874  LMNA; lamin [KO:K12641]
103285945  LMNB1; lamin-B1 isoform X2 [KO:K07611]
103294266  LMNB2; lamin-B2 isoform X1 [KO:K07611]
103304280  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
103303499  PARP2; poly [ADP-ribose] polymerase 2 [KO:K10798] [EC:2.4.2.30]
103300458  PARP3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
114232647  protein mono-ADP-ribosyltransferase PARP3-like [KO:K10798] [EC:2.4.2.30]
103301260  PARP4; LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP4 [KO:K10798] [EC:2.4.2.30]
103295316  DFFA; DNA fragmentation factor subunit alpha [KO:K02310]
103295384  DFFB; DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
103296180  ENDOG; endonuclease G, mitochondrial [KO:K01173]
103297209  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
103293136  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103295968  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103300420  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103285158  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103303043  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103302077  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
103293526  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
103303784  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
103297430  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
103283643  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103288848  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103292464  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
103294360  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
103296996  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
103303253  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
103290946  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
103303838  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
103298978  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
103287330  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
129147073  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
103286627  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
103304265  procathepsin L [KO:K01365] [EC:3.4.22.15]
103297882  procathepsin L [KO:K01365] [EC:3.4.22.15]
114228115  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
129151930  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
103290855  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
103298976  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
103290973  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
103303530  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
103292960  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103292961  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
103301896  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
103298251  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
103291033  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
103302915  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
103285583  BCL2L1; bcl-2-like protein 1 [KO:K04570]
103303728  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
129146987  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
103302882  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
103295688  DAB2IP; disabled homolog 2-interacting protein isoform X1 [KO:K19901]
103305290  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
103301660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
103292821  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103287875  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103302047  BAD; bcl2-associated agonist of cell death [KO:K02158]
103284067  JUN; transcription factor Jun [KO:K04448]
103283560  FOS; protein c-Fos [KO:K04379]
103296897  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
129148055  HRK; activator of apoptosis harakiri [KO:K02512]
103293009  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103288473  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103288179  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103302255  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103301979  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103299786  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103291087  RELA; transcription factor p65 isoform X1 [KO:K04735]
103287986  PTPN13; tyrosine-protein phosphatase non-receptor type 13 [KO:K02374]
103284106  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103294264  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103299999  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103295679  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
103304291  BCL2A1; bcl-2-related protein A1 [KO:K02162]
103302570  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
103297683  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
103293277  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
103297265  CASP2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
103291218  NGF; beta-nerve growth factor [KO:K02582]
103298850  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
129150036  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
103288900  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103299551  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103305161  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103294784  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103290523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103285154  KRAS; GTPase KRas isoform X1 [KO:K07827]
103291212  NRAS; GTPase NRas [KO:K07828]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103294231  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Related
pathway
efus04010  MAPK signaling pathway
efus04020  Calcium signaling pathway
efus04064  NF-kappa B signaling pathway
efus04115  p53 signaling pathway
efus04141  Protein processing in endoplasmic reticulum
efus04151  PI3K-Akt signaling pathway
efus04650  Natural killer cell mediated cytotoxicity
efus04668  TNF signaling pathway
KO pathway
ko04210   
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