KEGG   PATHWAY: efus04010
Entry
efus04010                   Pathway                                
Name
MAPK signaling pathway - Eptesicus fuscus (big brown bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
efus04010  MAPK signaling pathway
efus04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103283126  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
103283309  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
103283409  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
103283488  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
103283554  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
103283560  FOS; protein c-Fos [KO:K04379]
103283571  PGF; placenta growth factor isoform X1 [KO:K16859]
103283614  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
103283651  MAX; protein max isoform X4 [KO:K04453]
103283684  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
103283761  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103283781  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103284067  JUN; transcription factor Jun [KO:K04448]
103284106  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103284108  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103284158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103284220  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103284314  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X2 [KO:K04418] [EC:2.7.11.25]
103284347  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
103284349  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
103284564  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103284606  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103284692  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
103284970  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103284972  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
103284973  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
103285095  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103285154  KRAS; GTPase KRas isoform X1 [KO:K07827]
103285212  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
103285249  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
103285309  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103285349  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
103285537  FGF1; fibroblast growth factor 1 [KO:K18496]
103285639  CDC25B; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
103285814  ANGPT4; angiopoietin-4 [KO:K05467]
103286023  HSPB1; heat shock protein beta-1 [KO:K04455]
103286378  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103286395  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
103286498  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
103286714  [KO:K04393]
103286715  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
103286991  CRKL; crk-like protein [KO:K04438]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103287061  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
103287091  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
103287256  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
103287296  RASGRP1; RAS guanyl-releasing protein 1 isoform X3 [KO:K04350]
103287344  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103287415  FGF7; fibroblast growth factor 7 [KO:K04358]
103287517  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103287518  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103287682  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
103287875  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103287907  FGF5; fibroblast growth factor 5 [KO:K04358]
103287940  AREG; amphiregulin [KO:K09782]
103288015  EREG; proepiregulin [KO:K09784]
103288035  FGF6; fibroblast growth factor 6 [KO:K04358]
103288062  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103288064  KITLG; kit ligand isoform X2 [KO:K05461]
103288115  FGF23; fibroblast growth factor 23 [KO:K22428]
103288179  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103288473  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103288512  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103288555  DUSP5; dual specificity protein phosphatase 5 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103288651  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103288686  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
103288735  EFNA5; ephrin-A5 isoform X2 [KO:K05462]
103288794  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103288848  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103288851  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103288853  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
103288892  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103288904  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
103288953  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103288995  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
103289002  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103289069  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103289160  [KO:K04393]
103289342  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103289468  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103289828  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103289966  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103290114  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
103290127  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103290249  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103290293  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103290305  FGF20; fibroblast growth factor 20 [KO:K04358]
103290416  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
103290420  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103290482  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
103290852  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
103290874  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103290985  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
103291051  FGF3; fibroblast growth factor 3 [KO:K04358]
103291052  FGF4; fibroblast growth factor 4 [KO:K04358]
103291053  FGF19; fibroblast growth factor 19 [KO:K22603]
103291087  RELA; transcription factor p65 isoform X1 [KO:K04735]
103291183  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
103291212  NRAS; GTPase NRas [KO:K07828]
103291218  NGF; beta-nerve growth factor [KO:K02582]
103291338  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103291446  TGFA; protransforming growth factor alpha [KO:K08774]
103291470  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103291549  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103291622  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
103291696  NF1; neurofibromin isoform X1 [KO:K08052]
103291699  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
103291737  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
103291758  CRK; adapter molecule crk isoform X1 [KO:K04438]
103291913  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
103291926  STMN1; stathmin [KO:K04381]
103291971  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103292019  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
103292056  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
103292278  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X2 [KO:K04445] [EC:2.7.11.1]
103292317  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
103292358  MYC; myc proto-oncogene protein [KO:K04377]
103292412  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
103292464  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
103292519  RAP1B; ras-related protein Rap-1b [KO:K07836]
103292593  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
103292699  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103292722  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
103292821  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103292852  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103293009  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103293050  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103293119  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103293120  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103293121  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
103293123  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103293150  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
103293163  MAPT; microtubule-associated protein tau isoform X2 [KO:K04380]
103293241  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
103293251  HGF; hepatocyte growth factor [KO:K05460]
103293460  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103293466  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103293505  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
103293603  ARRB1; beta-arrestin-1 [KO:K04439]
103293618  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103293777  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103293793  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103294008  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103294085  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
103294199  NRTN; neurturin [KO:K25414]
103294231  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103294241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103294264  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103294278  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
103294302  EFNA2; ephrin-A2 [KO:K05462]
103294320  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
103294377  PSPN; persephin [KO:K25416]
103294577  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103294676  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
103294913  ARTN; artemin [KO:K25415]
103295001  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103295027  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X7 [KO:K04431] [EC:2.7.12.2]
103295071  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
103295085  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103295167  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
103295224  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
103295435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103295457  VEGFC; vascular endothelial growth factor C [KO:K05449]
103295508  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
103295577  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103295744  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103295746  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103295948  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103295968  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103296018  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
103296121  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
103296185  MRAS; ras-related protein M-Ras [KO:K07831]
103296210  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103296211  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103296275  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103296397  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103296401  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
103296406  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
103296626  VEGFA; vascular endothelial growth factor A [KO:K05448]
103296645  SRF; serum response factor [KO:K04378]
103296724  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103296752  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103296758  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103296831  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
103296832  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
103296845  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103296897  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
103297077  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103297130  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
103297165  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
103297168  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103297187  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103297281  [KO:K03283]
103297376  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
103297477  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103297493  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
103297641  NTF4; neurotrophin-4 [KO:K12457]
103297653  FGF21; fibroblast growth factor 21 [KO:K22429]
103297695  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
103297766  RRAS; ras-related protein R-Ras [KO:K07829]
103297769  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
103297815  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103298161  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103298181  VEGFD; vascular endothelial growth factor D [KO:K05449]
103298291  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103298330  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103298339  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103298493  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
103298527  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X2 [KO:K04859]
103298650  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103298707  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103298714  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
103298773  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
103298815  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103298850  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103298904  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
103298905  EFNA3; ephrin-A3 isoform X4 [KO:K05462]
103298906  EFNA4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
103299146  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103299170  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103299196  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103299365  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
103299424  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
103299482  [KO:K04453]
103299547  JUND; transcription factor JunD [KO:K04449]
103299786  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103299789  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103299796  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
103299827  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
103299834  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103299847  ARRB2; beta-arrestin-2 [KO:K04439]
103299999  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103300460  [KO:K03283]
103300478  TNF; tumor necrosis factor isoform X1 [KO:K03156]
103300527  [KO:K03283]
103300528  [KO:K03283]
103300680  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
103300744  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103300850  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103300989  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
103301022  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
103301061  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
103301099  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X3 [KO:K04405]
103301216  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103301270  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103301304  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
103301400  RELB; transcription factor RelB [KO:K09253]
103301660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
103301676  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103301950  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103301961  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
103302042  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
103302054  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
103302057  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
103302092  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
103302208  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
103302227  FLNA; filamin-A isoform X1 [KO:K04437]
103302249  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
103302255  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103302357  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103302464  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103302931  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
103303238  IL1A; interleukin-1 alpha [KO:K04383]
103303246  IL1B; interleukin-1 beta [KO:K04519]
103303252  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103303256  IGF2; insulin-like growth factor II [KO:K13769]
103303257  INS; insulin [KO:K04526]
103303283  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103303300  [KO:K07830]
103303550  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103303578  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103303646  FGF16; fibroblast growth factor 16 [KO:K04358]
103303678  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103303687  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
103303689  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
103303711  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103303839  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
103303990  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
103304083  STK4; serine/threonine-protein kinase 4 [KO:K04411]
103304154  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
103304832  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103304878  [KO:K03283]
103305235  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103305251  MEF2C; myocyte-specific enhancer factor 2C isoform X2 [KO:K04454]
103305290  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
103305361  RASA1; ras GTPase-activating protein 1 isoform X2 [KO:K04352]
103305449  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
103305666  SOS1; son of sevenless homolog 1 [KO:K03099]
114228252  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
114229025  [KO:K05096] [EC:2.7.10.1]
114230272  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
114234667  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129146987  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
129147700  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
129149245  FGF2; fibroblast growth factor 2 [KO:K18497]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
efus04070  Phosphatidylinositol signaling system
efus04110  Cell cycle
efus04115  p53 signaling pathway
efus04210  Apoptosis
efus04310  Wnt signaling pathway
efus04668  TNF signaling pathway
KO pathway
ko04010   

DBGET integrated database retrieval system