KEGG   PATHWAY: gvr00230
Entry
gvr00230                    Pathway                                
Name
Purine metabolism - Galeopterus variegatus (Sunda flying lemur)
Class
Metabolism; Nucleotide metabolism
Pathway map
gvr00230  Purine metabolism
gvr00230

Module
gvr_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:gvr00230]
gvr_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:gvr00230]
gvr_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:gvr00230]
gvr_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:gvr00230]
gvr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:gvr00230]
gvr_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:gvr00230]
gvr_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:gvr00230]
Other DBs
GO: 0006163 0042278
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103581214  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
103581798  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
103581970  [KO:K00940] [EC:2.7.4.6]
103581971  [KO:K03783] [EC:2.4.2.1]
103581992  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
103582572  [KO:K18532] [EC:2.7.4.3]
103583204  [KO:K08047] [EC:4.6.1.1]
103583324  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
103583798  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
103584936  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
103585002  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
103585013  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
103585049  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
103585195  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
103585597  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
103585644  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
103585653  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
103586004  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103586170  [KO:K00939] [EC:2.7.4.3]
103586287  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
103586297  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
103586379  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
103586937  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
103586938  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
103587029  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
103587378  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
103587539  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
103587683  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
103587861  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
103587974  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
103588356  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
103588664  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103588815  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103588825  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
103588863  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103588987  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
103589004  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
103589331  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
103589358  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
103589597  [KO:K00365] [EC:1.7.3.3]
103590144  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103590153  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
103590243  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
103590271  HDDC2; HD domain-containing protein 2 isoform X1 [KO:K07023] [EC:3.1.3.89]
103590734  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
103590965  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
103591043  [KO:K11265] [EC:4.6.1.1]
103591384  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103591503  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
103591602  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
103591872  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103591934  [KO:K01835] [EC:5.4.2.2]
103592526  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
103592745  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
103592922  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103592932  [KO:K00939] [EC:2.7.4.3]
103593213  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
103593512  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
103593607  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103593653  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
103593727  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
103594225  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
103594292  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
103594296  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
103594374  PDE1A; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
103594561  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
103594779  [KO:K01081] [EC:3.1.3.5]
103594899  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
103594947  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103594956  CECR1; adenosine deaminase CECR1 [KO:K19572] [EC:3.5.4.4]
103595077  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
103595079  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
103595434  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
103595655  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
103595656  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
103595720  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
103595832  [KO:K01081] [EC:3.1.3.5]
103596233  NT5E; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
103596288  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
103596389  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
103596471  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103596613  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
103597052  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
103597102  [KO:K13293] [EC:3.1.4.53]
103597578  PRPS1; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
103597776  [KO:K12319] [EC:4.6.1.2]
103597851  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
103597918  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103598041  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
103598374  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
103598590  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
103598775  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
103598913  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
103599368  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
103599565  [KO:K10808] [EC:1.17.4.1]
103599611  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103600198  PRUNE; protein prune homolog [KO:K01514] [EC:3.6.1.11]
103600834  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
103601157  GDA; LOW QUALITY PROTEIN: guanine deaminase [KO:K01487] [EC:3.5.4.3]
103601554  ADSS; LOW QUALITY PROTEIN: adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
103601745  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
103601930  PGM2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
103601939  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
103602195  GUCY1A3; guanylate cyclase soluble subunit alpha-3 isoform X1 [KO:K12318] [EC:4.6.1.2]
103602197  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
103602305  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
103602441  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
103602557  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103602561  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
103603086  [KO:K13296] [EC:3.1.4.17]
103603264  [KO:K00948] [EC:2.7.6.1]
103603581  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
103603768  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
103604265  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
103605201  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
103605765  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
103605867  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
103606003  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
103606004  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
103606253  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
103606638  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
103606693  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
103606845  [KO:K00856] [EC:2.7.1.20]
103607418  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
103607437  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
103607565  [KO:K07127] [EC:3.5.2.17]
103607698  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
103607881  XDH; LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103608520  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
103609605  [KO:K01510] [EC:3.6.1.5]
103610444  ENTPD6; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
gvr00030  Pentose phosphate pathway
gvr00220  Arginine biosynthesis
gvr00250  Alanine, aspartate and glutamate metabolism
gvr00260  Glycine, serine and threonine metabolism
gvr00340  Histidine metabolism
gvr00630  Glyoxylate and dicarboxylate metabolism
gvr00730  Thiamine metabolism
gvr00740  Riboflavin metabolism
gvr00790  Folate biosynthesis
KO pathway
ko00230   

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