KEGG   PATHWAY: hhv04662
Entry
hhv04662                    Pathway                                
Name
B cell receptor signaling pathway - Hyaena hyaena (striped hyena)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
Pathway map
hhv04662  B cell receptor signaling pathway
hhv04662

Other DBs
GO: 0050853
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120242822  CD79A; B-cell antigen receptor complex-associated protein alpha chain [KO:K06506]
120234173  CD79B; B-cell antigen receptor complex-associated protein beta chain isoform X1 [KO:K06507]
120222462  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
120237950  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
120220893  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
120220780  DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229]
120230555  BLNK; B-cell linker protein isoform X1 [KO:K07371]
120226858  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
120247171  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
120247312  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
120227958  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120241186  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120228188  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120223989  BANK1; B-cell scaffold protein with ankyrin repeats isoform X1 [KO:K26239]
120222045  BLK; tyrosine-protein kinase Blk isoform X1 [KO:K08890] [EC:2.7.10.2]
120228197  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120225617  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
120233735  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120239494  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120220964  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
120236651  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
120240942  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120230427  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
120223543  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120228194  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120220282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
120244628  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120244026  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
120223392  HRAS; GTPase HRas isoform X1 [KO:K02833]
120223531  KRAS; GTPase KRas [KO:K07827]
120243068  NRAS; GTPase NRas [KO:K07828]
120231327  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120221655  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120242086  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120238830  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242212  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
120231952  FOS; proto-oncogene c-Fos [KO:K04379]
120236252  JUN; transcription factor AP-1 [KO:K04448]
120233260  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120227987  CARD11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367]
120241653  BCL10; B-cell lymphoma/leukemia 10 isoform X1 [KO:K07368]
120230763  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
120243217  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120233999  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120226622  IKBKG; NF-kappa-B essential modulator [KO:K07210]
120222817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120240185  RELA; transcription factor p65 [KO:K04735]
120248609  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
120244615  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
120231261  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
120223423  interferon-induced transmembrane protein 1-like [KO:K19831]
120233929  CD81; CD81 antigen [KO:K06508]
120226900  CD81 antigen-like [KO:K06508]
120242187  CD19; B-lymphocyte antigen CD19 [KO:K06465]
120230487  CR2; complement receptor type 2 [KO:K04012]
120219997  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120239233  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120247089  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120233608  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120220979  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120246696  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120242922  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120241067  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
120233350  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
120245127  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 [KO:K15909] [EC:3.1.3.86]
120239669  LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
120239722  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512]
120239724  LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512]
120239725  LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
120239728  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1 [KO:K06512]
120239731  LILRA5; leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1 [KO:K06512]
120239744  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
120243493  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
120221271  CD72; B-cell differentiation antigen CD72 isoform X1 [KO:K06504]
120220450  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
120230592  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12461567
  Authors
Niiro H, Clark EA.
  Title
Regulation of B-cell fate by antigen-receptor signals.
  Journal
Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955
Reference
PMID:10358768
  Authors
Kurosaki T.
  Title
Genetic analysis of B cell antigen receptor signaling.
  Journal
Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555
Reference
PMID:15886119
  Authors
Nitschke L.
  Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
  Journal
Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005
Reference
PMID:15752555
  Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
  Title
Complement: central to innate immunity and bridging to adaptive responses.
  Journal
Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010
Reference
PMID:12033741
  Authors
Kurosaki T.
  Title
Regulation of B-cell signal transduction by adaptor proteins.
  Journal
Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801
Reference
PMID:15364057
  Authors
Nitschke L, Tsubata T.
  Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
  Journal
Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002
Reference
PMID:15771577
  Authors
Jumaa H, Hendriks RW, Reth M.
  Title
B cell signaling and tumorigenesis.
  Journal
Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606
Reference
PMID:15886112
  Authors
Rickert RC.
  Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
  Journal
Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001
Reference
PMID:15457440
  Authors
Zouali M, Sarmay G
  Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
  Journal
Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487
Reference
PMID:15322145
  Authors
Chiles TC.
  Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
  Journal
J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901
Reference
PMID:15626471
  Authors
Allam A, Marshall AJ
  Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
  Journal
Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019
Reference
PMID:12119152
  Authors
Gold MR
  Title
To make antibodies or not: signaling by the B-cell antigen receptor.
  Journal
Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X
Reference
PMID:9697839
  Authors
Fu C, Turck CW, Kurosaki T, Chan AC
  Title
BLNK: a central linker protein in B cell activation.
  Journal
Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9
Reference
PMID:11163197
  Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
  Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
  Journal
Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0
Reference
PMID:18086859
  Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
  Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
  Journal
J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379
Related
pathway
hhv04010  MAPK signaling pathway
hhv04020  Calcium signaling pathway
hhv04064  NF-kappa B signaling pathway
hhv04120  Ubiquitin mediated proteolysis
hhv04151  PI3K-Akt signaling pathway
hhv04610  Complement and coagulation cascades
hhv04810  Regulation of actin cytoskeleton
KO pathway
ko04662   
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