KEGG   PATHWAY: lroh04310
Entry
lroh04310                   Pathway                                
Name
Wnt signaling pathway - Labeo rohita (rohu)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
lroh04310  Wnt signaling pathway
lroh04310

Other DBs
GO: 0016055
Organism
Labeo rohita (rohu) [GN:lroh]
Gene
127170288  porcnl; LOW QUALITY PROTEIN: porcupine O-acyltransferase like [KO:K00181] [EC:2.3.1.250]
127169199  porcn; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
127154336  wnt1; protein Wnt-1 [KO:K03209]
127167083  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
127180919  wnt2; protein Wnt-2 [KO:K00182]
127169167  wnt2bb; wingless-type MMTV integration site family, member 2Bb [KO:K00182]
127173697  wnt3; proto-oncogene Wnt-3 [KO:K00312]
127152730  wnt3a; protein Wnt-3a [KO:K00312]
127178678  wnt4b; LOW QUALITY PROTEIN: wingless-type MMTV integration site family, member 4b [KO:K00408]
127173194  wnt4; protein Wnt-4a [KO:K00408]
127170034  wnt5a; protein Wnt-5a [KO:K00444]
127164047  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
127170910  wnt6b; protein Wnt-6 [KO:K00445]
127166453  wnt6a; protein Wnt-6 isoform X1 [KO:K00445]
127163714  wnt7ba; protein Wnt-7b [KO:K00572]
127154959  protein Wnt-7a [KO:K00572]
127157110  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
127173517  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
127176573  wnt8a; protein Wnt-8a ORF1 isoform X1 [KO:K00714]
127176574  protein Wnt-8a ORF2 [KO:K00714]
127175379  wnt8b; protein Wnt-8b [KO:K00714]
127156470  wnt9b; protein Wnt-9b [KO:K01064]
127152722  wnt9a; LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
127171021  wnt10a; protein Wnt-10a [KO:K01357]
127155085  wnt10b; protein Wnt-10b [KO:K01357]
127165705  wnt11f2; protein Wnt-11 isoform X1 [KO:K01384]
127172543  wnt11; protein Wnt-11 [KO:K01384]
127164296  wnt16; protein Wnt-16 [KO:K01558]
127165940  dand5; DAN domain family member 5 [KO:K01645]
127172866  notum1b; inactive palmitoleoyl-protein carboxylesterase notum1b isoform X1 [KO:K19882] [EC:3.1.1.98]
127167089  notum2; carboxylesterase notum2 [KO:K19882] [EC:3.1.1.98]
127162334  notum1a; palmitoleoyl-protein carboxylesterase notum1a [KO:K19882] [EC:3.1.1.98]
127164153  wif1; wnt inhibitory factor 1 [KO:K01691]
127174062  sost; sclerostin [KO:K16834]
127176409  dkk2; dickkopf-related protein 2 [KO:K02165]
127174095  dkk1b; dickkopf-related protein 1b isoform X1 [KO:K02165]
127174716  dkk1a; dickkopf WNT signaling pathway inhibitor 1a [KO:K02165]
127169367  dickkopf-related protein 4 isoform X1 [KO:K02165]
127152950  serpinf1; pigment epithelium-derived factor [KO:K19614]
127171520  sfrp1b; secreted frizzled-related protein 1b [KO:K02166]
127166109  sfrp1a; secreted frizzled-related protein 1a [KO:K02166]
127171786  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
127177630  sfrp2l; secreted frizzled-related protein 2-like isoform X1 [KO:K02176]
127170600  frzb; secreted frizzled-related protein 3 [KO:K25481]
127175029  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
127177917  rspo1; R-spondin-1 [KO:K19471]
127177845  rspo2; R-spondin-2 [KO:K23097]
127177938  rspo3; R-spondin-3 [KO:K23098]
127168273  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
127155223  leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
127165350  E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
127165696  znrf3; E3 ubiquitin-protein ligase znrf3 [KO:K16273] [EC:2.3.2.27]
127171448  fzd7a; frizzled-7a [KO:K02432]
127166629  fzd7b; frizzled-7b [KO:K02432]
127178746  fzd1; frizzled-1 [KO:K02432]
127156637  fzd2; frizzled-2 [KO:K02235]
127179501  fzd3b; frizzled-3b [KO:K02329]
127182779  fzd3a; frizzled-3a isoform X1 [KO:K02329]
127177706  fzd4; frizzled-4 [KO:K02354]
127170670  fzd5; frizzled-5 [KO:K02375]
127155826  fzd8a; frizzled-8a [KO:K02375]
127175050  fzd8b; frizzled-8b [KO:K02375]
127178716  fzd6; frizzled-6 isoform X1 [KO:K02376]
127170202  fzd10; frizzled-10 [KO:K02842]
127164782  fzd9a; frizzled-9 [KO:K02842]
127180899  fzd9b; frizzled-9b [KO:K02842]
127163889  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
127156641  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
127174630  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
127174848  bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b [KO:K10162]
127154730  protein APCDD1 isoform X1 [KO:K25812]
127155950  protein APCDD1-like [KO:K25812]
127166396  apcdd1l; protein APCDD1-like [KO:K25812]
127174424  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
127180088  ccdc88c; protein Daple isoform X1 [KO:K25811]
127154482  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
127173264  dvl1b; segment polarity protein dishevelled homolog DVL-1b isoform X1 [KO:K02353]
127167630  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
127151930  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
127180864  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
127179167  gbp; glycogen synthase kinase binding protein [KO:K03096]
127182215  zgc:86598; STKc_CK2_alpha domain-containing protein [KO:K03097] [EC:2.7.11.1]
127178485  csnk2a1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
127157043  csnk2a2b; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
127161305  csnk2a4; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
127168235  csnk2a2a; casein kinase 2, alpha prime polypeptide a [KO:K03097] [EC:2.7.11.1]
127181880  csnk2b; casein kinase II subunit beta [KO:K03115]
127178438  nkd2b; protein naked cuticle homolog 2-like [KO:K03213]
127168651  nkd1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
127154775  CXXC-type zinc finger protein 4 [KO:K03344]
127180785  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
127166954  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
127170027  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
127170699  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127178294  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
127181728  catenin beta-1 [KO:K02105]
127162714  axin1; axin-1 isoform X1 [KO:K02157]
127163382  axin2; axin-2 [KO:K04385]
127171793  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
127172975  apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
127175866  csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
127152460  tcf7; transcription factor 7 isoform X1 [KO:K02620]
127169871  tcf7l1b; transcription factor 7-like 1-B [KO:K04490]
127172457  tcf7l1a; transcription factor 7-like 1-A [KO:K04490]
127174150  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
127170696  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
127174117  lzts2b; leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
127175176  lzts2a; leucine zipper putative tumor suppressor 2a [KO:K26471]
127154504  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
127173653  cby1; protein chibby homolog 1 [KO:K23402]
127178511  chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
127165520  mcc; colorectal mutant cancer protein isoform X1 [KO:K26734]
127171500  ccar2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
127175514  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
127168712  sox17; transcription factor SOX-17 [KO:K04495]
127175938  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
127176130  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
127179674  ctbp2a; C-terminal-binding protein 2a isoform X1 [KO:K04496] [EC:1.1.1.428]
127174261  ctbp2l; C-terminal binding protein 2, like isoform X1 [KO:K04496] [EC:1.1.1.428]
127153984  tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497]
127153987  tle2b; transducin-like enhancer protein 4 isoform X1 [KO:K04497]
127167904  tle3b; transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
127180786  tle3a; transducin-like enhancer protein 3-A [KO:K04497]
127156067  ctnnd2a; LOW QUALITY PROTEIN: catenin delta-2 [KO:K23491]
127178413  ctnnd2b; catenin delta-2b isoform X1 [KO:K23491]
127153462  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
127163514  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
127159023  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
127174523  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
127166891  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
127165029  smad4b; mothers against decapentaplegic homolog 4 [KO:K04501]
127171745  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
127178786  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
127181773  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
127168307  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
127180610  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
127182744  map3k7; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
127176734  nlk2; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
127162656  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
127154385  mycb; transcriptional regulator Myc-B [KO:K04377]
127156107  myca; transcriptional regulator Myc-A [KO:K04377]
127165315  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
127183046  jun; transcription factor AP-1 [KO:K04448]
127176061  fosl1a; fos-related antigen 1a [KO:K04502]
127168605  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
127164391  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
127156478  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
127153789  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
127178996  ccn4b; cellular communication network factor 4b [KO:K22471]
127181530  ccn4a; cellular communication network factor 4a isoform X1 [KO:K22471]
127162523  pparda; peroxisome proliferator-activated receptor delta [KO:K04504]
127169476  ppardb; peroxisome proliferator-activated receptor delta b isoform X1 [KO:K04504]
127179713  psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
127172869  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
127159391  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
127168154  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127180703  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
127165300  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
127160767  cellular tumor antigen p53 [KO:K04451]
127180608  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
127178100  cacybp; calcyclin-binding protein [KO:K04507]
127152463  skp1; S-phase kinase-associated protein 1 [KO:K03094]
127170748  tbl1x; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
127172915  tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508]
127182902  tbl1xr1b; F-box-like/WD repeat-containing protein TBL1XR1b [KO:K04508]
127175976  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
127172473  fbxw11b; F-box and WD repeat domain-containing 11-B isoform X1 [KO:K03362]
127182512  cul1a; cullin-1a [KO:K03347]
127155627  cul1b; cullin-1b [KO:K03347]
127163576  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
127176199  gpc4; glypican-4 [KO:K08110]
127166361  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
127171727  ror2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
127167042  ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
127171384  vangl1; vang-like protein 1 [KO:K04510]
127166411  vang-like protein 1 isoform X1 [KO:K04510]
127168834  vangl2; vang-like protein 2 [KO:K04510]
127170019  prickle2a; prickle-like protein 2 isoform X1 [KO:K04511]
127170285  prickle3; LOW QUALITY PROTEIN: prickle planar cell polarity protein 3 [KO:K04511]
127164535  prickle1b; prickle-like protein 1b isoform X1 [KO:K04511]
127156716  prickle1a; prickle-like protein 1a [KO:K04511]
127173152  prickle2b; prickle-like protein 2b isoform X1 [KO:K04511]
127179014  invs; inversin isoform X1 [KO:K19626]
127180158  daam1a; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
127180196  daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
127183137  daam1b; disheveled-associated activator of morphogenesis 1b isoform X1 [KO:K04512]
127154872  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
127166810  rhoca; ras homolog family member Ca [KO:K04513]
127157396  rho-related GTP-binding protein RhoA-B-like isoform X1 [KO:K04513]
127169411  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
127169606  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
127175639  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
127183479  rock2b; rho-associated protein kinase 2b isoform X1 [KO:K17388] [EC:2.7.11.1]
127164254  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127178200  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127158366  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127174083  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127168243  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127162984  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
127163181  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
127174070  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
127163279  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
127173973  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127152220  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127174909  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127152675  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127179467  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
127179468  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127168134  plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
127179936  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
127182802  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127182984  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
127169829  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127171585  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
127165937  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127167888  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127174003  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127174722  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
127152422  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
127175900  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127165049  ppp3cca; LOW QUALITY PROTEIN: protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
127171792  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
127152224  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127168857  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127152322  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
127175128  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
127166764  prkcaa; LOW QUALITY PROTEIN: protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
127163386  prkcab; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
127160219  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127163312  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
127178761  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
127182089  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
127155041  nfatc2a; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
127167018  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
127156555  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
127168966  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
127172772  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
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