KEGG   PATHWAY: lroh04110
Entry
lroh04110                   Pathway                                
Name
Cell cycle - Labeo rohita (rohu)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
lroh04110  Cell cycle
lroh04110

Other DBs
GO: 0000278
Organism
Labeo rohita (rohu) [GN:lroh]
Gene
127168605  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
127164391  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
127156478  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
127153789  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
127173464  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
127181958  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
127163123  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
127152067  rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
127167362  rbl1; retinoblastoma-like protein 1 [KO:K04681]
127156553  rbl2; retinoblastoma-like protein 2 [KO:K16332]
127165996  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
127182133  hdac1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
127154346  e2f1; transcription factor E2F1 [KO:K17454]
127179326  e2f2; transcription factor E2F2 [KO:K09389]
127181333  e2f3; transcription factor E2F3 [KO:K06620]
127157058  e2f4; transcription factor E2F4 [KO:K04682]
127174357  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
127171132  tfdp1a; transcription factor Dp-1a [KO:K04683]
127171677  tfdp1b; transcription factor Dp-1b [KO:K04683]
127177301  tfdp2; transcription factor Dp-2 isoform X1 [KO:K09392]
127170027  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
127170699  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127177456  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
127152294  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
127176018  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
127178652  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
127179824  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
127172601  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
127168307  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
127180610  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
127165029  smad4b; mothers against decapentaplegic homolog 4 [KO:K04501]
127171745  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
127178786  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
127181773  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
127154385  mycb; transcriptional regulator Myc-B [KO:K04377]
127156107  myca; transcriptional regulator Myc-A [KO:K04377]
127155092  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
127169175  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
127167040  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
127164397  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
127156930  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
127156407  cdkn1cb; cyclin-dependent kinase inhibitor 1C [KO:K09993]
127168477  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
127153631  cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
127164043  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
127182189  G1/S-specific cyclin-E2-like [KO:K06626]
127177885  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
127167666  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
127161301  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
127152463  skp1; S-phase kinase-associated protein 1 [KO:K03094]
127182512  cul1a; cullin-1a [KO:K03347]
127155627  cul1b; cullin-1b [KO:K03347]
127163576  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
127152634  skp2; LOW QUALITY PROTEIN: S-phase kinase-associated protein 2 [KO:K03875]
127176536  ccna2; cyclin-A2 [KO:K06627]
127171539  ccna1; cyclin-A1 [KO:K06627]
127172650  cdc6; cell division control protein 6 homolog [KO:K02213]
127168450  cdt1; DNA replication factor Cdt1 [KO:K10727]
127166336  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
127173431  orc2; origin recognition complex subunit 2 [KO:K02604]
127179224  orc3; origin recognition complex subunit 3 [KO:K02605]
127167414  orc4; origin recognition complex subunit 4 [KO:K02606]
127163988  orc5; origin recognition complex subunit 5 [KO:K02607]
127168743  orc6; origin recognition complex subunit 6 [KO:K02608]
127153273  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
127151847  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
127183439  mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like [KO:K02541] [EC:5.6.2.3]
127155379  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
127163287  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
127166280  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
127173944  mcm6l; MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
127176628  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
127170122  cdc45; cell division control protein 45 homolog [KO:K06628]
127157133  ticrr; LOW QUALITY PROTEIN: treslin [KO:K26117]
127178882  mtbp; mdm2-binding protein [KO:K26116]
127174372  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
127179009  dbf4; protein DBF4 homolog A [KO:K06629]
127174561  dbf4b; protein DBF4 homolog B [KO:K06629]
127180018  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
127164692  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
127180416  G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
127167664  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
127167763  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
127175099  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
127181854  ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
127178495  ywhabl; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like [KO:K16197]
127166700  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
127179932  ywhaqb; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b [KO:K16197]
127169359  ywhabb; 14-3-3 protein beta/alpha-B [KO:K16197]
127182953  ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a [KO:K16197]
127177265  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
127168119  ywhae2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2 isoform X1 [KO:K06630]
127177433  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
127165588  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
127171719  ywhah; 14-3-3 protein eta [KO:K16198]
127169537  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
127180342  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
127180407  wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
127174497  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
127165034  ccnh; cyclin-H [KO:K06634]
127165340  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
127175267  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
127166127  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
127163133  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
127182464  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
127169148  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
127170713  cdc16; cell division cycle protein 16 homolog [KO:K03353]
127170331  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
127152102  cdc23; cell division cycle protein 23 homolog [KO:K03355]
127154592  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
127166549  anapc11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
127164999  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
127152534  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
127177639  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
127174286  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
127172795  cdc20; cell division cycle protein 20 homolog [KO:K03363]
127176288  pttg1; securin [KO:K06635]
127167307  espl1; separin [KO:K02365] [EC:3.4.22.49]
127154741  smc1al; structural maintenance of chromosomes 1A, like [KO:K06636]
127155274  smc1a; LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 1A [KO:K06636]
127156826  smc1b; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
127154245  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
127182125  rad21b; RAD21 cohesin complex component b [KO:K06670]
127178774  rad21a; double-strand-break repair protein rad21 homolog A [KO:K06670]
127169294  rad21l1; double-strand-break repair protein rad21-like protein 1 [KO:K06670]
127176077  stag2b; cohesin subunit SA-2 isoform X1 [KO:K06671]
127164963  stag2a; cohesin subunit SA-2a [KO:K06671]
127170941  si:ch211-269e2.1; cohesin subunit SA-2 [KO:K06671]
127155904  stag1b; cohesin subunit SA-1 [KO:K06671]
127178152  stag1a; cohesin subunit SA-1a [KO:K06671]
127176461  atrx; transcriptional regulator ATRX [KO:K10779]
127165052  transcriptional regulator ATRX-like isoform X1 [KO:K10779]
127180990  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
127165016  nipbla; LOW QUALITY PROTEIN: nipped-B-like protein A [KO:K06672]
127171977  nipblb; nipped-B-like protein B isoform X1 [KO:K06672]
127183260  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
127168812  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
127155713  esco1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
127183452  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
127163520  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
127177386  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
127179833  wapla; wings apart-like protein homolog [KO:K25163]
127173945  waplb; wings apart-like protein homolog [KO:K25163]
127165672  cdca5; sororin [KO:K17390]
127176644  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
127182044  sgo1; shugoshin 1 isoform X1 [KO:K11580]
127176377  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
127171956  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
127152461  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
127176846  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
127165263  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
127179835  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
127168413  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
127175010  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
127175244  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
127182992  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
127183176  ppp2r5ea; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
127183378  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
127173745  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
127171858  knl1; uncharacterized protein knl1 isoform X1 [KO:K11542]
127177891  ttk; dual specificity protein kinase Ttk isoform X1 [KO:K08866] [EC:2.7.12.1]
127167518  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
127168535  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
127169824  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
127179941  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
127173701  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
127182600  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
127178756  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
127175429  MAD2L1-binding protein isoform X1 [KO:K26093]
127175430  LOW QUALITY PROTEIN: MAD2L1-binding protein-like [KO:K26093]
127170259  fzr1a; LOW QUALITY PROTEIN: fizzy/cell division cycle 20 related 1a [KO:K03364]
127180942  fzr1b; fizzy-related protein homolog [KO:K03364]
127183292  fizzy-related protein homolog [KO:K03364]
127174757  fbxo5; LOW QUALITY PROTEIN: F-box only protein 5 [KO:K10292]
127153256  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
127169952  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
127179049  cdc14aa; cell division cycle 14Aa isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
127153462  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
127163514  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
127159023  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
127174523  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
127168194  prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
127152506  atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
127177153  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
127164122  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
127165300  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
127160767  cellular tumor antigen p53 [KO:K04451]
127169699  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
127154806  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
127173084  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
127167386  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
127173994  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
127152353  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
127171883  pcna; proliferating cell nuclear antigen [KO:K04802]
127152033  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
127164710  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
Reference
PMID:7908906
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Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
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J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
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Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
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Cell 75:779-90 (1993)
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Reference
PMID:16936746
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  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
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Oncogene 25:5263-7 (2006)
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Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
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Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
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Genes Dev 12:3499-511 (1998)
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Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
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J Cell Sci 121:3853-7 (2008)
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Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
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Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
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Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
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Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
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Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
lroh03030  DNA replication
lroh04010  MAPK signaling pathway
lroh04120  Ubiquitin mediated proteolysis
lroh04210  Apoptosis
KO pathway
ko04110   
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