PATHWAY: mmu04152 Help
Entry Name AMPK signaling pathway - Mus musculus (house mouse)
Description AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Mus musculus (house mouse) [GN:
mmu ]
Gene 108097 Prkab2; protein kinase, AMP-activated, beta 2 non-catalytic subunit [KO:K07199 ]
108099 Prkag2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit [KO:K07200 ]
11450 Adipoq; adiponectin, C1Q and collagen domain containing [KO:K07296 ]
11549 Adra1a; adrenergic receptor, alpha 1a [KO:K04135 ]
12683 Cidea; cell death-inducing DNA fragmentation factor, alpha subunit-like effector A [KO:K25893 ]
12912 Creb1; cAMP responsive element binding protein 1 [KO:K05870 ]
12913 Creb3; cAMP responsive element binding protein 3 [KO:K09048 ]
13629 Eef2; eukaryotic translation elongation factor 2 [KO:K03234 ]
13685 Eif4ebp1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205 ]
15378 Hnf4a; hepatic nuclear factor 4, alpha [KO:K07292 ]
15568 Elavl1; ELAV like RNA binding protein 1 [KO:K13088 ]
17274 Rab8a; RAB8A, member RAS oncogene family [KO:K07901 ]
18706 Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
18708 Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
18709 Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
18710 Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
19016 Pparg; peroxisome proliferator activated receptor gamma [KO:K08530 ]
19017 Ppargc1a; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [KO:K07202 ]
19052 Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
19053 Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [KO:K04382 ] [EC:3.1.3.16 ]
19054 Ppp2r3d; protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta [KO:K11583 ]
19079 Prkab1; protein kinase, AMP-activated, beta 1 non-catalytic subunit [KO:K07199 ]
19082 Prkag1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit [KO:K07200 ]
19325 Rab10; RAB10, member RAS oncogene family [KO:K07903 ]
19326 Rab11b; RAB11B, member RAS oncogene family [KO:K07905 ]
20528 Slc2a4; solute carrier family 2 (facilitated glucose transporter), member 4 [KO:K07191 ]
20787 Srebf1; sterol regulatory element binding transcription factor 1 [KO:K07197 ]
208647 Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048 ]
208677 Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048 ]
21770 Ppp2r5d; protein phosphatase 2, regulatory subunit B', delta [KO:K11584 ]
225849 Ppp2r5b; protein phosphatase 2, regulatory subunit B', beta [KO:K11584 ]
226849 Ppp2r5a; protein phosphatase 2, regulatory subunit B', alpha [KO:K11584 ]
227154 Stradb; STE20-related kinase adaptor beta [KO:K17532 ]
231991 Creb5; cAMP responsive element binding protein 5 [KO:K09047 ]
235542 Ppp2r3a; protein phosphatase 2, regulatory subunit B'', alpha [KO:K11583 ]
241113 Prkag3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit [KO:K07200 ]
26427 Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048 ]
26931 Ppp2r5c; protein phosphatase 2, regulatory subunit B', gamma [KO:K11584 ]
26932 Ppp2r5e; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584 ]
269643 Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354 ]
51792 Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456 ]
52432 Ppp2r2d; protein phosphatase 2, regulatory subunit B, delta [KO:K04354 ]
59021 Rab2a; RAB2A, member RAS oncogene family [KO:K07877 ]
59032 Ppp2r3c; protein phosphatase 2, regulatory subunit B'', gamma [KO:K11583 ]
68365 Rab14; RAB14, member RAS oncogene family [KO:K07881 ]
69008 Cab39l; calcium binding protein 39-like [KO:K08272 ]
71978 Ppp2r2a; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354 ]
72149 Strada; STE20-related kinase adaptor alpha [KO:K08271 ]
72930 Ppp2r2b; protein phosphatase 2, regulatory subunit B, beta [KO:K04354 ]
73699 Ppp2r1b; protein phosphatase 2, regulatory subunit A, beta [KO:K03456 ]
74343 Crtc2; CREB regulated transcription coactivator 2 [KO:K16333 ]
74370 Rptor; regulatory associated protein of MTOR, complex 1 [KO:K07204 ]
74769 Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
78284 Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048 ]
Compound C00354 D-Fructose 1,6-bisphosphate
C00665 beta-D-Fructose 2,6-bisphosphate
C00668 alpha-D-Glucose 6-phosphate
C01172 beta-D-Glucose 6-phosphate
C04677 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C09731 Epigallocatechin gallate
Reference Authors Steinberg GR, Kemp BE
Title AMPK in Health and Disease.
Journal Reference Authors Hardie DG.
Title The AMP-activated protein kinase pathway--new players upstream and downstream.
Journal Reference Authors Russo GL, Russo M, Ungaro P
Title AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
Journal Reference Authors Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
Title AMPK in the brain: its roles in energy balance and neuroprotection.
Journal Reference Authors Li J, McCullough LD
Title Effects of AMP-activated protein kinase in cerebral ischemia.
Journal Reference Authors Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
Title The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
Journal Reference Authors Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
Title Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
Journal Reference Authors Shackelford DB, Shaw RJ
Title The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
Journal Reference Authors Chung JH, Manganiello V, Dyck JR
Title Resveratrol as a calorie restriction mimetic: therapeutic implications.
Journal Reference Authors Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
Title Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Journal Reference Authors Towler MC, Hardie DG
Title AMP-activated protein kinase in metabolic control and insulin signaling.
Journal Reference Authors Richter EA, Hargreaves M
Title Exercise, GLUT4, and skeletal muscle glucose uptake.
Journal Reference Authors Kahn BB, Alquier T, Carling D, Hardie DG
Title AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Journal Reference Authors Minokoshi Y, Toda C, Okamoto S
Title Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
Journal Reference Authors Guggino WB, Stanton BA
Title New insights into cystic fibrosis: molecular switches that regulate CFTR.
Journal Reference Authors Cheng A, Saltiel AR
Title More TORC for the gluconeogenic engine.
Journal Reference Authors Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
Title TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
Journal Reference Authors Morris DL, Rui L
Title Recent advances in understanding leptin signaling and leptin resistance.
Journal Reference Authors Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
Title Role of hypothalamic AMP-kinase in food intake regulation.
Journal Reference Authors Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
Title Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
Journal Related mmu01040 Biosynthesis of unsaturated fatty acids
mmu04920 Adipocytokine signaling pathway
KO pathway
