KEGG   PATHWAY: nvs04142
Entry
nvs04142                    Pathway                                
Name
Lysosome biogenesis - Neogale vison (American mink)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
nvs04142  Lysosome biogenesis
nvs04142

Other DBs
GO: 0005764
Organism
Neogale vison (American mink) [GN:nvs]
Gene
122889108  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
122889295  [KO:K08515]
122889328  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
122889352  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
122889483  SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
122889708  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
122889764  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
122889801  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
122889858  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
122889922  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
122889967  TLR3; toll-like receptor 3 [KO:K05401]
122889986  BLOC1S4; biogenesis of lysosome-related organelles complex 1 subunit 4 [KO:K08366]
122890015  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
122890052  CLN8; protein CLN8 [KO:K12360]
122890100  [KO:K08515]
122890296  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
122890370  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
122891324  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
122891603  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
122891623  BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1 [KO:K20185]
122891713  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
122891983  CD63; CD63 antigen [KO:K06497]
122892326  BORCS5; BLOC-1-related complex subunit 5 isoform X1 [KO:K20819]
122892368  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
122892409  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
122892459  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
122892477  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
122892504  CLTB; clathrin light chain B isoform X1 [KO:K04645]
122892575  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
122892720  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
122892961  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
122893119  VPS13C; vacuolar protein sorting-associated protein 13C isoform X1 [KO:K19525]
122893120  CLN6; ceroid-lipofuscinosis neuronal protein 6 isoform X1 [KO:K12359]
122893171  [KO:K01319] [EC:3.4.21.20]
122893183  SPG11; spatacsin [KO:K19026]
122893266  BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188]
122893380  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
122893448  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
122893485  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
122893492  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
122893529  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
122893596  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
122893613  AP5M1; AP-5 complex subunit mu-1 isoform X1 [KO:K19023]
122893716  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
122893752  TMEM251; transmembrane protein 251 isoform X1 [KO:K26747]
122893815  SLC36A1; proton-coupled amino acid transporter 1 [KO:K14209]
122893822  SLC36A2; proton-coupled amino acid transporter 2 [KO:K14209]
122893831  GM2A; ganglioside GM2 activator [KO:K12383]
122893864  [KO:K12399]
122893968  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
122894123  ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 [KO:K19027]
122894233  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
122894343  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
122894360  VPS39; vam6/Vps39-like protein [KO:K20183]
122894413  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
122894631  [KO:K18467]
122895269  AP4M1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
122895312  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
122895328  CLCN7; H(+)/Cl(-) exchange transporter 7 isoform X1 [KO:K05016]
122895457  CLN3; battenin isoform X1 [KO:K12389]
122895480  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
122895552  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
122895567  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
122895593  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
122895604  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
122895625  ROGDI; protein rogdi homolog [KO:K24628]
122895651  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
122895838  AP5Z1; AP-5 complex subunit zeta-1 isoform X1 [KO:K19025]
122895858  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
122895867  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
122895937  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform X1 [KO:K19363]
122896269  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
122896434  TLR8; toll-like receptor 8 [KO:K10170]
122896907  TFE3; transcription factor E3 [KO:K09105]
122896986  VAMP7; vesicle-associated membrane protein 7 [KO:K08515]
122897040  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
122897061  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
122897079  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
122897207  TLR7; LOW QUALITY PROTEIN: toll-like receptor 7 [KO:K05404]
122897449  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
122897667  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
122897929  [KO:K01074] [EC:3.1.2.22]
122898635  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
122899139  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
122899234  [KO:K12394]
122899446  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122899569  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
122899781  RRAGC; ras-related GTP-binding protein C [KO:K16186]
122899808  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
122899872  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
122900133  CTBS; di-N-acetylchitobiase [KO:K12310] [EC:3.2.1.-]
122900139  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
122900141  MCOLN3; mucolipin-3 [KO:K04994]
122900288  SORT1; sortilin isoform X1 [KO:K12388]
122900312  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
122900350  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
122900432  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
122900434  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
122900650  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
122900742  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
122900765  SLC29A3; equilibrative nucleoside transporter 3 isoform X1 [KO:K15014]
122900770  [KO:K12382]
122900776  [KO:K02153]
122900812  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
122901018  BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2 [KO:K16750]
122901072  BORCS7; BLOC-1-related complex subunit 7 [KO:K20821]
122902101  SLC36A3; proton-coupled amino acid transporter 3 [KO:K14209]
122902254  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
122902302  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
122902358  AP1S3; AP-1 complex subunit sigma-3 isoform X1 [KO:K12395]
122902610  GPR155; integral membrane protein GPR155 isoform X1 [KO:K28455]
122902633  OSBPL6; oxysterol-binding protein-related protein 6 isoform X1 [KO:K20463]
122902809  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
122902859  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
122902973  OSBPL1A; oxysterol-binding protein-related protein 1 isoform X1 [KO:K20174]
122903051  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
122903059  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
122903080  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
122903093  SLC15A4; solute carrier family 15 member 4 [KO:K14638]
122903170  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
122903192  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
122903281  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
122903400  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
122903437  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
122903589  NPC1; NPC intracellular cholesterol transporter 1 [KO:K12385]
122903657  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
122903908  CD164; sialomucin core protein 24 [KO:K06546]
122903946  [KO:K02153]
122904084  OSTM1; osteopetrosis-associated transmembrane protein 1 [KO:K23863]
122904111  [KO:K01197] [EC:3.2.1.35]
122904112  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
122904340  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
122904383  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
122904413  LAPTM4B; lysosomal-associated transmembrane protein 4B isoform X1 [KO:K12387]
122904469  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
122904599  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
122904626  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
122904676  RRAGD; ras-related GTP-binding protein D [KO:K16186]
122904915  OSBPL3; oxysterol-binding protein-related protein 3 isoform X1 [KO:K20463]
122905049  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
122905114  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
122905196  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
122905438  [KO:K01197] [EC:3.2.1.35]
122905906  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
122905912  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
122905914  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
122905993  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
122906014  FUCA2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
122906043  ABCA5; cholesterol transporter ABCA5 isoform X1 [KO:K05648]
122906052  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
122906114  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
122906187  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
122906193  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
122906194  [KO:K02154]
122906465  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
122906513  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
122906639  OSBPL7; oxysterol-binding protein-related protein 7 isoform X1 [KO:K20463]
122906735  BORCS6; BLOC-1-related complex subunit 6 [KO:K20820]
122906826  CTNS; cystinosin isoform X1 [KO:K12386]
122906921  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
122907160  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
122907261  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
122907768  CD68; macrosialin [KO:K06501]
122907909  TFEB; transcription factor EB isoform X1 [KO:K15590]
122908514  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
122908686  SLC29A1; equilibrative nucleoside transporter 1 isoform X1 [KO:K15014]
122908735  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
122908753  AP2M1; AP-2 complex subunit mu [KO:K11826]
122909099  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
122909146  RAB7A; ras-related protein Rab-7a [KO:K07897] [EC:3.6.5.2]
122909249  ARL8B; LOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 8B [KO:K07955]
122909253  SUMF1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
122909276  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
122909365  [KO:K10161]
122909398  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
122909399  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
122909400  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
122909527  BORCS8; BLOC-1-related complex subunit 8 isoform X1 [KO:K20822]
122909575  KXD1; kxDL motif-containing protein 1 isoform X1 [KO:K20818]
122909637  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
122909679  DNASE2; LOW QUALITY PROTEIN: deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
122909694  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
122909701  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
122909726  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
122909784  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
122909914  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
122909920  SLC17A5; sialin isoform X1 [KO:K12301]
122910634  [KO:K02152]
122911134  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
122911175  MEAK7; MTOR-associated protein MEAK7 isoform X1 [KO:K27947]
122911274  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
122911290  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
122911315  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
122911344  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
122911485  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
122911496  NEU1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
122911789  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
122911802  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
122911807  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
122911818  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
122911910  AP2S1; AP-2 complex subunit sigma [KO:K11827]
122911950  BLOC1S3; biogenesis of lysosome-related organelles complex 1 subunit 3 [KO:K20186]
122912353  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
122912452  VPS26B; vacuolar protein sorting-associated protein 26B isoform X1 [KO:K18466]
122912492  SLC36A4; proton-coupled amino acid transporter 4 isoform X1 [KO:K14209]
122912500  [KO:K16344]
122912507  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
122912634  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
122912636  BLOC1S5; biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X1 [KO:K20187]
122912672  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
122912678  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
122912894  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
122912927  DTNBP1; dysbindin [KO:K20189]
122912959  [KO:K20456]
122913125  AP5B1; AP-5 complex subunit beta-1 [KO:K19022]
122913130  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
122913152  SLC29A2; equilibrative nucleoside transporter 2 isoform X1 [KO:K15014]
122913159  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
122913200  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
122913237  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
122913243  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
122913257  OSBPL5; oxysterol-binding protein-related protein 5 [KO:K20464]
122913271  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
122913686  SLC15A3; solute carrier family 15 member 3 [KO:K14638]
122914969  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
122915051  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
122915284  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
122915312  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
122915667  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
122915912  OSBPL2; oxysterol-binding protein-related protein 2 [KO:K20174]
122915931  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
122916021  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
122916087  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
122916141  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
122916207  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
122916223  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
122916230  AP5S1; AP-5 complex subunit sigma-1 [KO:K19024]
122916258  LAMP5; lysosome-associated membrane glycoprotein 5 [KO:K28774]
122916755  [KO:K01365] [EC:3.4.22.15]
122917077  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
122917097  SLC2A6; solute carrier family 2, facilitated glucose transporter member 6 [KO:K08144]
122917319  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
122917410  STX17; syntaxin-17 [KO:K08491]
122917465  CLTA; clathrin light chain A isoform X1 [KO:K04644]
122917578  RRAGA; ras-related GTP-binding protein A [KO:K16185]
122917617  [KO:K01365] [EC:3.4.22.15]
122917636  [KO:K01365] [EC:3.4.22.15]
122917637  [KO:K01365] [EC:3.4.22.15]
122917638  [KO:K01365] [EC:3.4.22.15]
122917679  VPS13A; vacuolar protein sorting-associated protein 13A isoform X1 [KO:K19525]
122918172  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
122918210  SNAPIN; SNARE-associated protein Snapin [KO:K20002]
122918257  GBA; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
122918276  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
122918286  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
122918290  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
122918551  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
122918792  ARL8A; ADP-ribosylation factor-like protein 8A [KO:K07955]
122918855  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
122919089  SCARB2; lysosome membrane protein 2 [KO:K12384]
122919133  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
122919135  TMEM175; endosomal/lysosomal potassium channel TMEM175 isoform X1 [KO:K24915]
122919286  [KO:K12399]
Compound
C00002  ATP
C00008  ADP
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Reference
PMID:19672277
  Authors
Saftig P, Klumperman J
  Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
  Journal
Nat Rev Mol Cell Biol 10:623-35 (2009)
DOI:10.1038/nrm2745
Reference
PMID:31611045
  Authors
Savini M, Zhao Q, Wang MC
  Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
  Journal
Trends Cell Biol 29:876-887 (2019)
DOI:10.1016/j.tcb.2019.08.008
Reference
PMID:33433692
  Authors
Meyer-Schwesinger C
  Title
Lysosome function in glomerular health and disease.
  Journal
Cell Tissue Res 385:371-392 (2021)
DOI:10.1007/s00441-020-03375-7
Reference
PMID:34345172
  Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
  Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
  Journal
Int J Nanomedicine 16:5065-5098 (2021)
DOI:10.2147/IJN.S321343
Reference
PMID:36096887
  Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
  Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
  Journal
Nat Commun 13:5351 (2022)
DOI:10.1038/s41467-022-33025-1
Reference
PMID:38357444
  Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
  Title
The host mannose-6-phosphate pathway and viral infection.
  Journal
Front Cell Infect Microbiol 14:1349221 (2024)
DOI:10.3389/fcimb.2024.1349221
Reference
PMID:38711187
  Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
  Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
  Journal
Med Res Rev 44:2472-2509 (2024)
DOI:10.1002/med.22047
Reference
PMID:40759742
  Authors
Radulovic M, Yang C, Stenmark H
  Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
  Journal
Nat Rev Mol Cell Biol 27:71-87 (2026)
DOI:10.1038/s41580-025-00873-w
Reference
PMID:41214333
  Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
  Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
  Journal
Nat Rev Mol Cell Biol 26:940-956 (2025)
DOI:10.1038/s41580-025-00907-3
Related
pathway
nvs00511  Other glycan degradation
nvs00531  Glycosaminoglycan degradation
nvs04130  SNARE interactions in vesicular transport
nvs04140  Autophagy - animal
nvs04144  Endocytosis
nvs04145  Phagocytosis
nvs04150  mTOR signaling pathway
nvs04620  Toll-like receptor signaling pathway
KO pathway
ko04142   

DBGET integrated database retrieval system