KEGG   PATHWAY: nvs04140
Entry
nvs04140                    Pathway                                
Name
Autophagy - animal - Neogale vison (American mink)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
nvs04140  Autophagy - animal
nvs04140

Other DBs
GO: 0006914
Organism
Neogale vison (American mink) [GN:nvs]
Gene
122889452  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122889455  WDFY3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
122889708  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
122889911  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
122891093  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
122891110  PRKCQ; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
122891208  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
122891343  OPTN; optineurin isoform X1 [KO:K19946]
122891679  [KO:K04382] [EC:3.1.3.16]
122891893  ATG101; autophagy-related protein 101 [KO:K19730]
122892446  KRAS; GTPase KRas isoform X1 [KO:K07827]
122892965  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122892975  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
122893084  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
122893108  [KO:K08770]
122893272  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
122893492  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
122893938  [KO:K08341]
122893967  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
122894106  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
122894164  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
122894172  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122894188  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
122894203  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
122894360  VPS39; vam6/Vps39-like protein [KO:K20183]
122894750  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
122895255  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
122895342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122895593  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
122895932  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
122896052  [KO:K17445]
122896129  TSC2; tuberin isoform X1 [KO:K07207]
122896395  ATG4A; cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
122896690  [KO:K21245]
122896701  [KO:K21245]
122896702  [KO:K21245]
122896783  IGBP1; immunoglobulin-binding protein 1 isoform X1 [KO:K17606]
122896971  WDR45; WD repeat domain phosphoinositide-interacting protein 4 isoform X1 [KO:K22991]
122897036  RAB39B; ras-related protein Rab-39B [KO:K07925]
122897040  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
122897407  IRS4; insulin receptor substrate 4 [KO:K17446]
122897449  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
122897983  [KO:K17907]
122898740  [KO:K10802]
122899136  [KO:K07828]
122899425  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122899446  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122899781  RRAGC; ras-related GTP-binding protein C [KO:K16186]
122899916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122900018  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122900040  ATG4C; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
122900129  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122900157  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
122900359  NRAS; GTPase NRas [KO:K07828]
122900613  [KO:K02927]
122900668  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122900714  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
122900777  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
122900866  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122901119  [KO:K02927]
122901226  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
122901238  PRAP1; proline-rich acidic protein 1 isoform X1 [KO:K21250]
122901882  [KO:K08343]
122902187  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
122902329  ATG9A; autophagy-related protein 9A [KO:K17907]
122902369  IRS1; insulin receptor substrate 1 [KO:K16172]
122902430  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
122902484  ATG4B; LOW QUALITY PROTEIN: cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
122902529  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
122902582  GORASP2; Golgi reassembly-stacking protein 2 [KO:K26797]
122902835  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
122902908  EPG5; ectopic P granules protein 5 homolog isoform X1 [KO:K23883]
122902914  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
122903051  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
122903087  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
122903104  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
122903192  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
122903200  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122903270  MTMR3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
122903449  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
122904214  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
122904340  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
122904521  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122904603  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
122904626  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
122904674  YKT6; synaptobrevin homolog YKT6 [KO:K08516]
122904676  RRAGD; ras-related GTP-binding protein D [KO:K16186]
122904938  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
122905199  ATG9B; autophagy-related protein 9B [KO:K17907]
122905217  RHEB; GTP-binding protein Rheb [KO:K07208]
122905855  WDR45B; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
122905906  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
122906054  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
122906080  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
122906114  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
122906162  NBR1; next to BRCA1 gene 1 protein [KO:K17987]
122906173  BECN1; beclin-1 isoform X1 [KO:K08334]
122906505  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122906511  VMP1; vacuole membrane protein 1 [KO:K21248]
122906526  MTMR4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
122906582  STX7; syntaxin-7 [KO:K08488]
122906612  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
122906688  [KO:K08341]
122906794  UBB; polyubiquitin-B [KO:K08770]
122906817  [KO:K08269] [EC:2.7.11.1]
122906870  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
122906999  HMGB1; high mobility group protein B1 [KO:K10802]
122907030  SUPT20H; transcription factor SPT20 homolog isoform X1 [KO:K21245]
122907240  IRS2; insulin receptor substrate 2 [KO:K07187]
122907261  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
122907279  [KO:K02977]
122907396  ULK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
122908503  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
122908712  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122908845  RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
122908899  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122908906  MRAS; ras-related protein M-Ras [KO:K07831]
122908951  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
122909070  GORASP1; Golgi reassembly-stacking protein 1 isoform X1 [KO:K26797]
122909146  RAB7A; ras-related protein Rab-7a [KO:K07897]
122909192  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122909201  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
122909231  MTMR14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
122909251  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122909342  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
122909577  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
122909588  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122909639  RAB8A; ras-related protein Rab-8A [KO:K07901]
122909651  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122909729  ATG4D; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
122909871  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122909875  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
122909957  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
122911155  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
122911227  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
122911802  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
122911814  RRAS; ras-related protein R-Ras [KO:K07829]
122912036  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122912353  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
122912569  UVRAG; UV radiation resistance-associated gene protein [KO:K21249]
122912610  ATG16L2; protein Atg16l2 isoform X1 [KO:K20868]
122912742  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
122912786  [KO:K02977]
122912847  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122912882  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
122912884  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
122913061  BAD; bcl2-associated agonist of cell death [KO:K02158]
122913078  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
122913186  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
122913220  HRAS; GTPase HRas isoform X1 [KO:K02833]
122913243  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
122914590  INS; insulin [KO:K04526]
122915051  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
122915073  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
122915173  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
122915580  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
122915651  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122915724  SQSTM1; sequestosome-1 [KO:K14381]
122916140  TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
122916149  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
122916174  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
122916207  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
122916487  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
122916540  RAB1A; ras-related protein Rab-1A [KO:K07874]
122916755  [KO:K01365] [EC:3.4.22.15]
122917138  TSC1; hamartin [KO:K07206]
122917410  STX17; syntaxin-17 [KO:K08491]
122917542  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
122917578  RRAGA; ras-related GTP-binding protein A [KO:K16185]
122917617  [KO:K01365] [EC:3.4.22.15]
122917636  [KO:K01365] [EC:3.4.22.15]
122917637  [KO:K01365] [EC:3.4.22.15]
122917638  [KO:K01365] [EC:3.4.22.15]
122917639  DAPK1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
122917962  ATG10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
122917964  BECN2; beclin-2 [KO:K08334]
122917965  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
122918346  WDR41; WD repeat-containing protein 41 [KO:K23610]
122918510  [KO:K10802]
122918524  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122918741  [KO:K08343]
122918854  RAB7B; ras-related protein Rab-7b [KO:K07898]
122918946  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122919178  RAB33B; ras-related protein Rab-33B [KO:K07920]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
nvs04010  MAPK signaling pathway
nvs04141  Protein processing in endoplasmic reticulum
nvs04142  Lysosome biogenesis
nvs04150  mTOR signaling pathway
nvs04152  AMPK signaling pathway
nvs04910  Insulin signaling pathway
KO pathway
ko04140   

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