Entry
Name
Phagocytosis - Neogale vison (American mink)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Other DBs
Organism
Neogale vison (American mink) [GN:
nvs ]
Gene
122889801 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
122889938 MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558 ]
122891065 SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956 ]
122891208 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
122891458 CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074 ]
122891553 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
122891693 TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374 ]
122893492 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
122893569 TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 isoform X1 [KO:K26936 ]
122895567 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
122895963 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
122897449 LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
122899425 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
122899872 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
122899916 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
122900472 FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498 ]
122900839 SFTPD; pulmonary surfactant-associated protein D isoform X1 [KO:K10068 ]
122902484 ATG4B; LOW QUALITY PROTEIN: cysteine protease ATG4B [KO:K08342 ] [EC:3.4.22.-]
122902587 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
122902973 OSBPL1A; oxysterol-binding protein-related protein 1 isoform X1 [KO:K20174 ]
122903051 VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
122903086 SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885 ]
122904626 VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
122904648 SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342 ]
122904838 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
122905888 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182 ]
122906193 ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154 ]
122907261 LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528 ]
122908712 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
122908845 RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330 ]
122908899 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
122909057 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
122909141 SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956 ]
122909201 ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337 ]
122909588 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
122911155 MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
122911227 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
122911373 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
122912248 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
122912353 VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
122912569 UVRAG; UV radiation resistance-associated gene protein [KO:K21249 ]
122914969 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
122915312 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148 ]
122915580 MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
122916207 VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
122916349 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417 ]
122917246 GAPVD1; GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1 [KO:K27566 ]
122917965 MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
122918381 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560 ]
122918946 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
Authors
Stuart LM, Ezekowitz RA
Title
Phagocytosis: elegant complexity.
Journal
Reference
Authors
Tjelle TE, Lovdal T, Berg T
Title
Phagosome dynamics and function.
Journal
Reference
Authors
Dupuy AG, Caron E
Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal
Reference
Authors
Brumell JH, Grinstein S
Title
Salmonella redirects phagosomal maturation.
Journal
Reference
Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal
Reference
Authors
Luzio JP, Pryor PR, Bright NA
Title
Lysosomes: fusion and function.
Journal
Reference
Authors
Sumimoto H
Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal
Reference
Authors
Depierre M, Pompili C, Niedergang F
Title
Phagocytosis at a glance.
Journal
Reference
Authors
Lee HJ, Woo Y, Hahn TW, Jung YM, Jung YJ
Title
Formation and Maturation of the Phagosome: A Key Mechanism in Innate Immunity against Intracellular Bacterial Infection.
Journal
Reference
Authors
Heckmann BL, Green DR
Title
LC3-associated phagocytosis at a glance.
Journal
Reference
Authors
Yuan J, Zhang Q, Chen S, Yan M, Yue L
Title
LC3-Associated Phagocytosis in Bacterial Infection.
Journal
Reference
Authors
Pena-Martinez C, Rickman AD, Heckmann BL
Title
Beyond autophagy: LC3-associated phagocytosis and endocytosis.
Journal
Reference
Authors
Othman A, Sekheri M, Filep JG
Title
Roles of neutrophil granule proteins in orchestrating inflammation and immunity.
Journal
Reference
Authors
Rosales C
Title
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Journal
Reference
Authors
Naish E, Wood AJ, Stewart AP, Routledge M, Morris AC, Chilvers ER, Lodge KM
Title
The formation and function of the neutrophil phagosome.
Journal
Reference
Authors
Skubitz KM
Title
The role of CEACAMs in neutrophil function.
Journal
Reference
Authors
Weiss G, Schaible UE
Title
Macrophage defense mechanisms against intracellular bacteria.
Journal
Reference
Authors
Cruz FM, Chan A, Rock KL
Title
Pathways of MHC I cross-presentation of exogenous antigens.
Journal
Related pathway
nvs04610 Complement and coagulation cascades
nvs04612 Antigen processing and presentation
nvs04613 Neutrophil extracellular trap formation
nvs04620 Toll-like receptor signaling pathway
nvs04666 Fc gamma R-mediated phagosome formation
KO pathway