KEGG   PATHWAY: oga04150
Entry
oga04150                    Pathway                                
Name
mTOR signaling pathway - Otolemur garnettii (small-eared galago)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
oga04150  mTOR signaling pathway
oga04150

Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100940344  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
100940650  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X5 [KO:K04688] [EC:2.7.11.1]
100940736  FNIP2; folliculin-interacting protein 2 isoform X2 [KO:K20401]
100940907  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100941062  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100942390  WDR24; GATOR complex protein WDR24 [KO:K20408]
100942646  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
100942708  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
100943020  SOS2; son of sevenless homolog 2 [KO:K03099]
100943205  FZD10; frizzled-10 [KO:K02842]
100943348  FZD9; frizzled-9 [KO:K02842]
100943567  WNT10B; protein Wnt-10b [KO:K01357]
100943579  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100943606  WNT7B; protein Wnt-7b [KO:K00572]
100943890  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100943908  GRB10; growth factor receptor-bound protein 10 isoform X2 [KO:K20064]
100944076  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
100944079  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
100944169  STRADA; STE20-related kinase adapter protein alpha isoform X4 [KO:K08271]
100944265  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
100944394  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100944973  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
100945054  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
100945202  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X3 [KO:K04373] [EC:2.7.11.1]
100945268  RICTOR; rapamycin-insensitive companion of mTOR isoform X2 [KO:K08267]
100945502  PRR5L; proline-rich protein 5-like [KO:K20411]
100945805  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100946157  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100946311  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
100946400  WNT2; protein Wnt-2 [KO:K00182]
100946974  LAMTOR4; ragulator complex protein LAMTOR4 [KO:K20399]
100947138  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100947210  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
100947304  WNT10A; protein Wnt-10a [KO:K01357]
100947333  LPIN1; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
100947357  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100947535  MAPKAP1; LOW QUALITY PROTEIN: target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
100947622  WNT6; protein Wnt-6 [KO:K00445]
100947800  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100947881  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100947892  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100947964  FZD8; frizzled-8 [KO:K02375]
100947970  WNT8B; protein Wnt-8b [KO:K00714]
100948095  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
100948113  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
100948246  FNIP1; folliculin-interacting protein 1 isoform X2 [KO:K20400]
100948251  FZD1; frizzled-1 [KO:K02432]
100948701  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100948760  RRAGC; ras-related GTP-binding protein C [KO:K16186]
100948837  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
100948884  CAB39L; calcium-binding protein 39-like [KO:K08272]
100949073  RRAGA; ras-related GTP-binding protein A [KO:K16185]
100949227  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
100949314  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
100949554  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100949583  NRAS; GTPase NRas isoform X1 [KO:K07828]
100949858  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100950006  WNT5B; protein Wnt-5b [KO:K00444]
100950104  TELO2; telomere length regulation protein TEL2 homolog isoform X2 [KO:K11137]
100950210  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100950216  RHEB; GTP-binding protein Rheb [KO:K07208]
100950370  WNT4; protein Wnt-4 [KO:K00408]
100950583  SEC13; protein SEC13 homolog [KO:K14004]
100950673  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100950941  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
100951094  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100951339  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100951644  HRAS; GTPase HRas isoform X1 [KO:K02833]
100952182  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
100952411  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
100952470  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100952580  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100952751  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100952798  CAB39; calcium-binding protein 39 [KO:K08272]
100953050  KRAS; GTPase KRas isoform X3 [KO:K07827]
100953171  CLIP1; CAP-Gly domain-containing linker protein 1 [KO:K10421]
100953222  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
100953367  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100953828  FLCN; folliculin isoform X2 [KO:K09594]
100954109  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100954223  WNT11; protein Wnt-11 [KO:K01384]
100954489  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100954771  RHOA; transforming protein RhoA [KO:K04513]
100954800  WNT9B; protein Wnt-9b [KO:K01064]
100954949  TSC1; hamartin isoform X2 [KO:K07206]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100955336  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100955382  FZD6; frizzled-6 isoform X2 [KO:K02376]
100955618  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100955892  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100956229  SESN2; sestrin-2 [KO:K20394]
100956383  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
100956396  ATP6V1H; V-type proton ATPase subunit H isoform X2 [KO:K02144]
100956503  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
100956642  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
100956711  FZD3; frizzled-3 [KO:K02329]
100956811  TSC2; tuberin isoform X3 [KO:K07207]
100956838  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100956877  PRKCG; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100956942  DEPDC5; GATOR complex protein DEPDC5 [KO:K20404]
100956985  [KO:K03259]
100957093  WNT9A; protein Wnt-9a [KO:K01064]
100957215  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100957753  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100957955  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100958000  [KO:K20398]
100958076  WDR59; GATOR complex protein WDR59 isoform X4 [KO:K20409]
100958310  INS; insulin isoform X1 [KO:K04526]
100958517  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100958554  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
100958623  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
100958672  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
100958778  IRS1; insulin receptor substrate 1 [KO:K16172]
100958815  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100959119  WNT16; protein Wnt-16 [KO:K01558]
100959243  WNT7A; protein Wnt-7a [KO:K00572]
100959283  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100959472  RRAGD; ras-related GTP-binding protein D [KO:K16186]
100959575  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
100959731  [KO:K16185]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100960210  SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
100960463  TBC1D7; TBC1 domain family member 7 [KO:K20396]
100960603  WNT2B; protein Wnt-2b [KO:K00182]
100960641  RPS6; 40S ribosomal protein S6 [KO:K02991]
100961331  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
100961774  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100962237  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
100962307  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100962470  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
100962985  NPRL3; GATOR complex protein NPRL3 [KO:K20406]
100963018  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
100963272  FZD7; frizzled-7 [KO:K02432]
100963379  FZD5; frizzled-5 [KO:K02375]
100963421  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X5 [KO:K04373] [EC:2.7.11.1]
100963573  SEH1L; nucleoporin SEH1 [KO:K14299]
100963613  TNF; tumor necrosis factor [KO:K03156]
100963711  FZD2; frizzled-2 [KO:K02235]
100963859  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100963885  MIOS; GATOR complex protein MIOS [KO:K20407]
100963978  WNT8A; protein Wnt-8a [KO:K00714]
100964130  WNT3A; protein Wnt-3a [KO:K00312]
100964140  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
100964395  FZD4; frizzled-4 [KO:K02354]
100964563  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
100964943  NPRL2; GATOR complex protein NPRL2 isoform X2 [KO:K20405]
100965377  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100966499  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100966830  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105886373  PRR5; proline-rich protein 5 [KO:K20411]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
oga00561  Glycerolipid metabolism
oga04010  MAPK signaling pathway
oga04140  Autophagy - animal
oga04151  PI3K-Akt signaling pathway
oga04152  AMPK signaling pathway
oga04810  Regulation of actin cytoskeleton
oga04910  Insulin signaling pathway
KO pathway
ko04150   

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