KEGG   PATHWAY: oga04151
Entry
oga04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Otolemur garnettii (small-eared galago)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
oga04151  PI3K-Akt signaling pathway
oga04151

Other DBs
GO: 0043491
Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100940330  NRTN; neurturin [KO:K25414]
100940414  YWHAG; 14-3-3 protein gamma [KO:K16198]
100940422  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
100940650  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X5 [KO:K04688] [EC:2.7.11.1]
100940763  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100940909  F2R; proteinase-activated receptor 1 [KO:K03914]
100940920  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
100940990  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
100940993  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100941062  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100941510  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100941606  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
100941684  ITGB5; integrin beta-5 [KO:K06588]
100941749  PRL; prolactin isoform X2 [KO:K05439]
100941760  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100941807  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100941836  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
100941852  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
100941938  EPHA2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
100942002  IL2; interleukin-2 [KO:K05429]
100942103  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100942216  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100942388  FGF5; fibroblast growth factor 5 [KO:K04358]
100942631  FGF2; fibroblast growth factor 2 [KO:K18497]
100942748  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100942777  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
100942940  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
100943020  SOS2; son of sevenless homolog 2 [KO:K03099]
100943029  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100943181  IL7; interleukin-7 isoform X1 [KO:K05431]
100943372  PSPN; persephin [KO:K25416]
100943395  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100943574  PKN3; serine/threonine-protein kinase N3 [KO:K23692]
100943746  [KO:K05438]
100943772  THBS2; thrombospondin-2 [KO:K04659]
100943945  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
100944008  YWHAH; 14-3-3 protein eta [KO:K16198]
100944212  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3 [KO:K11583]
100944309  GDNF; glial cell line-derived neurotrophic factor isoform X5 [KO:K05452]
100944376  TNN; tenascin-N [KO:K06252]
100944394  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100944450  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X8 [KO:K11584]
100944569  LAMB1; laminin subunit beta-1 [KO:K05636]
100944640  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100944643  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100944802  TNR; tenascin-R isoform X1 [KO:K06252]
100944832  MYB; transcriptional activator Myb isoform X3 [KO:K09420]
100945029  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
100945148  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100945309  [KO:K05414]
100945380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100945428  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100945479  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
100945519  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
100945575  [KO:K16197]
100945623  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
100945805  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100945821  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2 [KO:K11584]
100945835  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100945899  ITGAV; integrin alpha-V [KO:K06487]
100945936  ITGA9; integrin alpha-9 [KO:K06585]
100945944  [KO:K05414]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100946038  IL4; interleukin-4 isoform X1 [KO:K05430]
100946157  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100946218  NGF; beta-nerve growth factor [KO:K02582]
100946241  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100946255  [KO:K05414]
100946581  ARTN; artemin [KO:K25415]
100946725  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100947062  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100947073  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100947082  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100947087  LAMB4; laminin subunit beta-4 [KO:K06245]
100947138  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100947271  [KO:K13304] [EC:2.7.11.1]
100947328  [KO:K06643] [EC:2.3.2.27]
100947419  FGF7; fibroblast growth factor 7 [KO:K04358]
100947566  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
100947685  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
100947708  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
100947735  FGF21; fibroblast growth factor 21 [KO:K22429]
100947892  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100948029  FGF18; fibroblast growth factor 18 [KO:K04358]
100948095  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
100948167  FN1; fibronectin isoform X2 [KO:K05717]
100948188  YWHAQ; 14-3-3 protein theta [KO:K16197]
100948196  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100948280  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583]
100948294  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100948347  FOXO3; forkhead box protein O3 [KO:K09408]
100948701  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100948800  THBS4; thrombospondin-4 [KO:K04659]
100948837  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
100948875  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100949138  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100949141  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100949231  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
100949247  THBS1; thrombospondin-1 [KO:K16857]
100949360  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
100949430  ITGB3; integrin beta-3 [KO:K06493]
100949483  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100949511  ITGA2; integrin alpha-2 [KO:K06481]
100949514  KITLG; kit ligand isoform X1 [KO:K05461]
100949554  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100949583  NRAS; GTPase NRas isoform X1 [KO:K07828]
100949628  HSP90B1; endoplasmin [KO:K09487]
100949858  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100949887  EREG; proepiregulin [KO:K09784]
100949905  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100950210  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100950216  RHEB; GTP-binding protein Rheb [KO:K07208]
100950302  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100950470  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100950477  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100950588  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
100950688  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100950768  ANGPT1; angiopoietin-1 isoform X2 [KO:K05465]
100950802  ITGA3; integrin alpha-3 [KO:K06482]
100950920  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
100950946  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
100950950  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100950964  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100950977  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
100951008  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100951061  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100951094  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100951247  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100951253  VEGFD; vascular endothelial growth factor D [KO:K05449]
100951347  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100951353  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100951422  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100951428  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100951443  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100951606  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100951644  HRAS; GTPase HRas isoform X1 [KO:K02833]
100951652  ITGA2B; integrin alpha-IIb [KO:K06476]
100951671  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100951748  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
100951769  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
100951797  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100952085  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100952184  AREG; amphiregulin [KO:K09782]
100952236  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100952411  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
100952454  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100952461  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
100952470  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100952566  LAMB2; laminin subunit beta-2 [KO:K06243]
100952580  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100952704  ITGA8; integrin alpha-8 [KO:K06584]
100952718  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100952751  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100952786  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
100952813  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100952916  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
100952938  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
100953017  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
100953032  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100953050  KRAS; GTPase KRas isoform X3 [KO:K07827]
100953119  LAMC2; laminin subunit gamma-2 [KO:K06246]
100953177  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100953298  FGF16; fibroblast growth factor 16 [KO:K04358]
100953367  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100953470  [KO:K16197]
100953638  LAMC1; laminin subunit gamma-1 [KO:K05635]
100953646  CHAD; chondroadherin [KO:K06248]
100953720  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100953746  MTCP1; protein p13 MTCP-1 [KO:K16837]
100953808  [KO:K06643] [EC:2.3.2.27]
100953964  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100954028  EPOR; erythropoietin receptor [KO:K05079]
100954109  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100954183  LAMA5; laminin subunit alpha-5 [KO:K06240]
100954240  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100954252  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100954515  FGF10; fibroblast growth factor 10 [KO:K04358]
100954553  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100954676  TNC; tenascin isoform X1 [KO:K06252]
100954742  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100954869  [KO:K04079]
100954949  TSC1; hamartin isoform X2 [KO:K07206]
100954954  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100955006  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100955062  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100955095  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100955362  VTN; vitronectin [KO:K06251]
100955384  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100955447  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100955618  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100955731  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100955745  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100955757  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100955762  ITGA4; integrin alpha-4 [KO:K06483]
100955816  NTF4; neurotrophin-4 [KO:K12457]
100955879  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
100955951  [KO:K05414]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100956114  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100956281  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
100956359  TLR4; toll-like receptor 4 [KO:K10160]
100956649  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100956703  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100956758  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
100956811  TSC2; tuberin isoform X3 [KO:K07207]
100956838  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100956865  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100956963  [KO:K05414]
100956985  [KO:K03259]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100957344  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
100957394  ANGPT4; angiopoietin-4 [KO:K05467]
100957401  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100957574  [KO:K05414]
100957667  FGFR4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
100957753  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100957773  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100957798  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100957904  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100957990  RELA; transcription factor p65 isoform X3 [KO:K04735]
100958098  FGF23; fibroblast growth factor 23 [KO:K22428]
100958104  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100958142  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100958215  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100958275  PRLR; prolactin receptor isoform X1 [KO:K05081]
100958310  INS; insulin isoform X1 [KO:K04526]
100958412  VWF; von Willebrand factor [KO:K03900]
100958440  [KO:K05414]
100958451  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
100958517  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100958585  FGF22; fibroblast growth factor 22 [KO:K04358]
100958617  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100958629  FGF4; fibroblast growth factor 4 [KO:K04358]
100958631  IGF2; insulin-like growth factor II isoform X3 [KO:K13769]
100958672  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
100958737  NTF3; neurotrophin-3 [KO:K04356]
100958763  [KO:K05414]
100958778  IRS1; insulin receptor substrate 1 [KO:K16172]
100958798  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100958815  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100958858  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
100958883  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100958917  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100958946  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100958947  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100959074  [KO:K05414]
100959168  YWHAE; 14-3-3 protein epsilon [KO:K06630]
100959235  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
100959248  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100959283  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100959381  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100959385  IFNB1; interferon beta [KO:K05415]
100959433  SPP1; osteopontin [KO:K06250]
100959676  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100959678  THBS3; thrombospondin-3 [KO:K04659]
100959686  EGF; pro-epidermal growth factor [KO:K04357]
100959749  IBSP; bone sialoprotein 2 [KO:K06253]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100959852  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100960272  VEGFA; vascular endothelial growth factor A [KO:K05448]
100960529  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100960579  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100960589  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100960612  LAMC3; laminin subunit gamma-3 [KO:K06247]
100960641  RPS6; 40S ribosomal protein S6 [KO:K02991]
100960708  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100960938  FGF3; fibroblast growth factor 3 [KO:K04358]
100961106  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
100961176  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
100961245  FGF6; fibroblast growth factor 6 [KO:K04358]
100961253  FGF19; fibroblast growth factor 19 [KO:K22603]
100961255  EPO; erythropoietin [KO:K05437]
100961335  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100961338  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100961557  EFNA1; ephrin-A1 [KO:K05462]
100961605  [KO:K06643] [EC:2.3.2.27]
100961872  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100961952  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100961987  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
100962025  LAMA3; laminin subunit alpha-3 [KO:K06240]
100962064  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
100962073  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100962075  EFNA3; ephrin-A3 [KO:K05462]
100962188  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100962201  [KO:K06238]
100962219  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100962237  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
100962306  BAD; bcl2-associated agonist of cell death [KO:K02158]
100962353  [KO:K05414]
100962354  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
100962373  PTK2; focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
100962391  FGF9; fibroblast growth factor 9 [KO:K04358]
100962509  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
100962528  ITGA6; integrin alpha-6 [KO:K06485]
100962590  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100962605  PKN1; serine/threonine-protein kinase N1 isoform X3 [KO:K06071] [EC:2.7.11.13]
100962660  PDGFD; platelet-derived growth factor D [KO:K05450]
100962815  [KO:K06238]
100963018  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
100963124  COMP; cartilage oligomeric matrix protein [KO:K04659]
100963155  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100963401  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100963412  OSM; oncostatin-M [KO:K05418]
100963426  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100963434  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100963467  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100963518  ITGB7; integrin beta-7 [KO:K06590]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100963850  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
100963859  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100964048  TLR2; toll-like receptor 2 [KO:K10159]
100964140  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
100964155  LAMA1; laminin subunit alpha-1 [KO:K05637]
100964179  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100964189  LAMA4; laminin subunit alpha-4 [KO:K06241]
100964324  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100964580  PDGFC; platelet-derived growth factor C [KO:K05450]
100964694  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100964729  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
100964809  FGF20; fibroblast growth factor 20 [KO:K04358]
100964880  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100965127  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
100965129  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100965274  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100965377  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100965465  ITGA11; integrin alpha-11 [KO:K06587]
100965771  LAMB3; laminin subunit beta-3 [KO:K06244]
100966077  FGF1; fibroblast growth factor 1 [KO:K18496]
100966148  GHR; growth hormone receptor isoform X2 [KO:K05080]
100966247  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
100966253  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100966324  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100966484  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
100966523  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100966830  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100966891  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
100966977  EFNA2; ephrin-A2 [KO:K05462]
100967014  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100967099  VEGFC; vascular endothelial growth factor C [KO:K05449]
100967179  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
111723289  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111723667  [KO:K04545]
111724020  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
111724938  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111725594  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
111726116  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
111727809  [KO:K06643] [EC:2.3.2.27]
111727847  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111728356  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
oga00010  Glycolysis / Gluconeogenesis
oga04010  MAPK signaling pathway
oga04012  ErbB signaling pathway
oga04062  Chemokine signaling pathway
oga04064  NF-kappa B signaling pathway
oga04068  FoxO signaling pathway
oga04110  Cell cycle
oga04115  p53 signaling pathway
oga04150  mTOR signaling pathway
oga04210  Apoptosis
oga04370  VEGF signaling pathway
oga04510  Focal adhesion
oga04620  Toll-like receptor signaling pathway
oga04630  JAK-STAT signaling pathway
oga04662  B cell receptor signaling pathway
oga04910  Insulin signaling pathway
KO pathway
ko04151   

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