Entry Name B cell receptor signaling pathway - Bos mutus (wild yak)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map bom04662 B cell receptor signaling pathway
Ortholog table Other DBs Organism Bos mutus (wild yak) [GN:
bom ]
Gene 102268126 tyrosine-protein phosphatase non-receptor type substrate 1 [KO:K06856 ]
102268229 DAPP1; dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [KO:K12229 ]
102273253 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392 ]
102277352 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860 ]
102286986 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861 ]
102266459 BANK1; B-cell scaffold protein with ankyrin repeats 1 [KO:K26239 ]
102272271 PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268 ]
102277736 PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268 ]
102285474 nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446 ]
102286943 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099 ]
102277585 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099 ]
102275053 FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379 ]
102267895 JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
102287968 IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210 ]
102266922 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
102280296 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
102286868 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
102273069 low affinity immunoglobulin gamma Fc region receptor II [KO:K12560 ]
102287875 leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512 ]
102277532 leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512 ]
102271419 leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512 ]
102284401 leukocyte immunoglobulin-like receptor subfamily B member 4 [KO:K06512 ]
102271977 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
106701680 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related bom04610 Complement and coagulation cascades
bom04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
