KEGG   PATHWAY: cbai00230
Entry
cbai00230                   Pathway                                
Name
Purine metabolism - Camelus bactrianus (Bactrian camel)
Class
Metabolism; Nucleotide metabolism
Pathway map
cbai00230  Purine metabolism
cbai00230

Module
cbai_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cbai00230]
cbai_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:cbai00230]
cbai_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cbai00230]
cbai_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cbai00230]
cbai_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cbai00230]
cbai_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cbai00230]
cbai_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cbai00230]
Other DBs
GO: 0006163 0042278
Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105077714  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
105077565  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
105067997  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
105064653  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
105074965  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
105077752  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
105061977  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
105077683  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
105070227  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
105077540  PFAS; LOW QUALITY PROTEIN: phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
105077682  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
105073095  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
105072932  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
105079440  APRT; adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
105081693  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
105082164  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
105062941  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
105065665  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
105072771  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
105072270  LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4-like [KO:K01081] [EC:3.1.3.5]
105083114  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
105064673  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
105066117  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
105079674  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
105080273  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
105063107  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
105080294  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
105068070  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
105064624  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
105064625  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
105064875  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
105065734  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
105077397  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
105081802  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
105061756  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
105073387  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
105065590  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
105068963  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
105074958  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
105083187  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
105073871  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
105083036  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
105063890  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105078758  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
105066712  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
105068811  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
105061597  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
105067275  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
105068032  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
105083267  RRM1; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105076030  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
105069627  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
105077193  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
105066977  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
105080397  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
105069080  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
105071735  PRUNE; protein prune homolog isoform X1 [KO:K01514] [EC:3.6.1.11]
105080525  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105081234  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105063873  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105068818  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105081635  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105076187  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105074271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105082946  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105064797  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105083904  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
105068061  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
105069394  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
105067608  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
105069370  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
105066302  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
105062249  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
105083617  LOW QUALITY PROTEIN: olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
105077586  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
105061968  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
105068204  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105067337  NPR2; LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
105081806  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
105076318  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
105072897  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
105083343  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
105062274  PDE3A; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
105076796  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
105067130  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
105069874  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
105071933  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
105081822  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
105069829  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
105065563  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1 [KO:K13759]
105062259  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
105078035  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
105065325  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
105072877  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
105079973  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
105083620  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
105076634  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
105079588  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
105063653  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
105075355  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
105071917  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
105076123  CECR1; adenosine deaminase CECR1 isoform X1 [KO:K19572] [EC:3.5.4.4]
105079914  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
105075518  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
105078394  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
105069718  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
105064602  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
105065965  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
105066748  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
105064406  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
105079175  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
105068603  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
105066694  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
105077221  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
105077429  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
105075561  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
105082570  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
105077788  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
105068383  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
105081461  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
105077256  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
105069099  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
105064358  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
105079550  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
105083836  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
105081864  PAPSS2; LOW QUALITY PROTEIN: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
105067938  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
105075495  uricase-like [KO:K00365] [EC:1.7.3.3]
105080866  5-hydroxyisourate hydrolase-like isoform X1 [KO:K07127] [EC:3.5.2.17]
105066318  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
105070515  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cbai00030  Pentose phosphate pathway
cbai00220  Arginine biosynthesis
cbai00250  Alanine, aspartate and glutamate metabolism
cbai00260  Glycine, serine and threonine metabolism
cbai00340  Histidine metabolism
cbai00630  Glyoxylate and dicarboxylate metabolism
cbai00730  Thiamine metabolism
cbai00740  Riboflavin metabolism
cbai00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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