KEGG   PATHWAY: cide04068
Entry
cide04068                   Pathway                                
Name
FoxO signaling pathway - Ctenopharyngodon idella (grass carp)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
cide04068  FoxO signaling pathway
cide04068

Other DBs
GO: 0009267
Organism
Ctenopharyngodon idella (grass carp) [GN:cide]
Gene
127495355  transforming growth factor, beta 1a isoform X1 [KO:K13375]
127503585  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
127494595  transforming growth factor beta-2 proprotein [KO:K13376]
127496922  transforming growth factor beta-2 proprotein [KO:K13376]
127498052  transforming growth factor beta-3 proprotein [KO:K13377]
127506415  TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
127498181  TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
127497383  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
127519363  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
127500561  mothers against decapentaplegic homolog 4 [KO:K04501]
127496713  mothers against decapentaplegic homolog 4 [KO:K04501]
127512124  mothers against decapentaplegic homolog 4 [KO:K04501]
127513285  mothers against decapentaplegic homolog 4-like [KO:K04501]
127520369  mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
127499865  mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
127516003  mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
127501770  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
127496481  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
127502675  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
127512635  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
127521199  5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
127517870  5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
127496686  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
127518302  5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
127512766  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127505542  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127505739  5'-AMP-activated protein kinase subunit gamma-2a isoform X1 [KO:K07200]
127514076  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127508611  nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
127495013  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
127503905  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
127510532  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
127525633  histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
127507819  LOW QUALITY PROTEIN: CREB binding protein b [KO:K04498] [EC:2.3.1.48]
127509763  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
127524081  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
127520672  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
127524433  NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
127508087  ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
127516638  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
127523601  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503188  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127524755  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127524923  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503882  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127511009  insulin-like growth factor I isoform X1 [KO:K05459]
127500363  insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
127516213  insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
127508035  insulin [KO:K04526]
127512529  insulin [KO:K04526]
127525708  LOW QUALITY PROTEIN: preproinsulin b [KO:K04526]
127521177  insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
127525545  insulin receptor a [KO:K04527] [EC:2.7.10.1]
127495986  insulin receptor substrate 1-B isoform X1 [KO:K16172]
127515379  insulin receptor substrate 2-B isoform X1 [KO:K07187]
127509202  insulin receptor substrate 2a isoform X1 [KO:K07187]
127518345  insulin receptor substrate 2 [KO:K07187]
127522246  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
127496217  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127504512  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127504906  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127514273  phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
127502660  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
127512708  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
127509098  3-phosphoinositide-dependent protein kinase 1a [KO:K06276] [EC:2.7.11.1]
127505885  3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
127524669  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
127517699  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
127499167  phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127523380  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127499652  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127521951  v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
127502735  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127525380  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127498588  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127498690  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127513634  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127501252  si:ch211-195b13.1; STKc_SGK domain-containing protein [KO:K13302] [EC:2.7.11.1]
127497706  serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
127504569  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
127505184  serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
127506464  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
127496190  forkhead box protein O1-A isoform X1 [KO:K07201]
127520074  forkhead box protein O1-B [KO:K07201]
127499197  forkhead box protein O3a [KO:K09408]
127501883  forkhead box protein O3B [KO:K09408]
127525736  forkhead box protein O4 [KO:K12358]
127497786  forkhead box protein O3 [KO:K17847]
127502626  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
127498452  metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
127499774  homer protein homolog 2 isoform X1 [KO:K15010]
127499818  homer protein homolog 3 isoform X1 [KO:K15010]
127522715  homer protein homolog 3b isoform X1 [KO:K15010]
127504048  homer protein homolog 1 isoform X1 [KO:K15010]
127512948  homer protein homolog 1b isoform X1 [KO:K15010]
127504656  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
127524028  casein kinase I [KO:K08960] [EC:2.7.11.1]
127501686  interleukin-6 [KO:K05405]
127522978  interleukin-10 [KO:K05443]
127510137  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
127494859  pro-epidermal growth factor [KO:K04357]
127506254  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
127505760  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
127508627  growth factor receptor-bound protein 2b [KO:K04364]
127514131  growth factor receptor-bound protein 2a [KO:K04364]
127522075  son of sevenless homolog 1 isoform X1 [KO:K03099]
127525055  son of sevenless homolog 2 [KO:K03099]
127507367  HRas proto-oncogene, GTPase a [KO:K02833]
127516364  HRas proto-oncogene, GTPase b [KO:K02833]
127506985  GTPase KRas isoform X1 [KO:K07827]
127508487  zgc:55558; GTPase KRas [KO:K07827]
127517208  GTPase NRas [KO:K07828]
127522563  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
127504685  raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127512955  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
127499431  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127502256  dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
127519987  dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
127509562  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
127513496  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
127499931  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
127522287  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
127517001  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
127517204  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
127510537  mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
127510539  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127505446  zgc:171775; LOW QUALITY PROTEIN: STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
127522811  cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
127509354  protein arginine N-methyltransferase 1 [KO:K11434] [EC:2.1.1.319]
127500196  forkhead box protein G1c [KO:K09385]
127522359  forkhead box protein G1-like [KO:K09385]
127522485  forkhead box protein G1b [KO:K09385]
127524517  forkhead box protein G1 [KO:K09385]
127499043  forkhead box protein G1 [KO:K09385]
127499394  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
127512710  G2/mitotic-specific cyclin-B1 [KO:K05868]
127515821  G2/mitotic-specific cyclin-B2 [KO:K21770]
127516277  G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
127516057  G1/S-specific cyclin-D1 [KO:K04503]
127506694  G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
127510934  G1/S-specific cyclin-D2b [KO:K10151]
127503752  cyclin-G2 [KO:K10146]
127514779  cyclin-dependent kinase 4 inhibitor D [KO:K06623]
127510898  cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
127521414  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
127506699  cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
127511559  cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
127507065  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
127512829  serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
127517929  serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
127520486  serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
127505254  serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
127498829  serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
127515000  growth arrest and DNA-damage-inducible, alpha, b isoform X1 [KO:K04402]
127522598  growth arrest and DNA-damage-inducible, beta a [KO:K04402]
127518010  growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
127496831  growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
127503716  growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
127498920  growth arrest and DNA-damage-inducible, beta b [KO:K04402]
127502691  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
127524821  bcl-2-like protein 11 [KO:K16341]
127506009  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
127523234  BCL6A transcription repressor b [KO:K15618]
127514000  BCL6A transcription repressor a [KO:K15618]
127523285  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
127512137  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
127498434  BCL2 interacting protein 4 [KO:K15464]
127497669  ubiquitin-like protein ATG12 [KO:K08336]
127507107  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
127515651  GABA(A) receptor-associated protein b [KO:K08341]
127496750  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
127512385  GABA(A) receptor-associated protein a [KO:K08341]
127507207  catalase [KO:K03781] [EC:1.11.1.6]
127501889  superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
127496255  serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
127506370  phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
127514725  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
127508450  glucose-6-phosphatase b [KO:K01084] [EC:3.1.3.9]
127523368  glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
127523689  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
127523691  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
127503412  interleukin-7 receptor subunit alpha [KO:K05072]
127521329  Krueppel-like factor 2a [KO:K17845]
127501139  Krueppel-like factor 2b [KO:K17845]
127521464  sphingosine 1-phosphate receptor 1 [KO:K04288]
127520464  sphingosine 1-phosphate receptor 4 [KO:K04293]
127507634  V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
127507443  V(D)J recombination-activating protein 2 [KO:K10988]
127496684  F-box only protein 32 [KO:K10305]
127505314  F-box only protein 25 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
cide00010  Glycolysis / Gluconeogenesis
cide00020  Citrate cycle (TCA cycle)
cide00190  Oxidative phosphorylation
cide04010  MAPK signaling pathway
cide04110  Cell cycle
cide04120  Ubiquitin mediated proteolysis
cide04140  Autophagy - animal
cide04210  Apoptosis
cide04350  TGF-beta signaling pathway
cide04910  Insulin signaling pathway
KO pathway
ko04068   
LinkDB

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