KEGG   PATHWAY: cpoc00230
Entry
cpoc00230                   Pathway                                
Name
Purine metabolism - Cavia porcellus (domestic guinea pig)
Class
Metabolism; Nucleotide metabolism
Pathway map
cpoc00230  Purine metabolism
cpoc00230

Module
cpoc_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cpoc00230]
cpoc_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:cpoc00230]
cpoc_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cpoc00230]
cpoc_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cpoc00230]
cpoc_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cpoc00230]
cpoc_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cpoc00230]
cpoc_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cpoc00230]
Other DBs
GO: 0006163 0042278
Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100716076  Nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
100735078  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X3 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100728957  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100723448  Nudt5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
100721478  Pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
100731750  Pgm2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
100735923  Prps1l1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
100713609  Prps2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
100725562  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
100730194  Ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
100729412  Gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
100730059  Pfas; LOW QUALITY PROTEIN: phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
100727779  Paics; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
100713101  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
100726313  Atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
100731502  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
100723874  Nt5c1a; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
100719756  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X2 [KO:K01081] [EC:3.1.3.5]
100727140  Nt5c2; cytosolic purine 5'-nucleotidase isoform X2 [KO:K01081] [EC:3.1.3.5]
100722645  Nt5c1b; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
100725593  Nt5e; LOW QUALITY PROTEIN: 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
100718329  Pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
100714334  Lacc1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
100727355  Hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
100717020  Impdh1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
100730768  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
100715313  Nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
100719085  Nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
100729023  Nme3; LOW QUALITY PROTEIN: nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
100379567  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
100725952  Nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106027056  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
100730706  LOW QUALITY PROTEIN: adenylate kinase 9-like [KO:K18533] [EC:2.7.4.3 2.7.4.6]
100727694  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X2 [KO:K01510] [EC:3.6.1.5]
100717436  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
100733912  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
100725891  Cant1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
100730248  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X2 [KO:K12305] [EC:3.6.1.6]
100721163  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
100379248  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
100718426  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
100718706  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
100718887  Itpa; inosine triphosphate pyrophosphatase isoform X2 [KO:K01519] [EC:3.6.1.66]
100731391  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100721527  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
100726973  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
100728263  Gmpr2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
100719409  Gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
100727963  Gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
100733447  Guk1; guanylate kinase isoform X3 [KO:K00942] [EC:2.7.4.8]
100728488  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111754150  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
100715474  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
100715485  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
100727551  Hddc2; HD domain-containing protein 2 isoform X1 [KO:K07023] [EC:3.1.3.89]
100713278  Dguok; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
100713916  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
100734745  Hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
100726799  Prune1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
100715672  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100731999  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100725667  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100715532  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100714732  Adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100731224  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100726699  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100722340  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100717226  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100721701  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
100732121  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100728275  Gucy1a1; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
100720742  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100723676  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
100135536  Gucy2c; heat-stable enterotoxin receptor precursor [KO:K12320] [EC:4.6.1.2]
100732548  Gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
100735737  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
100722890  Gucy2f; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
100728832  Npr1; LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100732021  Npr2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
100726194  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
100527956  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
100527959  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
100713716  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3 [KO:K18283] [EC:3.1.4.17]
100302667  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
100731540  Pde3b; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
100527958  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
100725241  Pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X3 [KO:K08718] [EC:3.1.4.35]
100721588  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
100527954  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
100734925  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
100135595  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
100735374  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
100302673  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
100527955  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100302674  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
100713988  Adssl1; adenylosuccinate synthetase isozyme 1 isoform X2 [KO:K01939] [EC:6.3.4.4]
100725405  Adss; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
100719930  Ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
100720840  Ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
100728217  Ampd3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
100726404  Adk; adenosine kinase [KO:K00856] [EC:2.7.1.20]
100720869  Ada; adenosine deaminase isoform X2 [KO:K01488] [EC:3.5.4.4]
100726292  Ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
100727823  Ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
100724853  Ak1; adenylate kinase isoenzyme 1 isoform X2 [KO:K00939] [EC:2.7.4.3]
100714579  Ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
100725972  Ak4; adenylate kinase 4, mitochondrial isoform X2 [KO:K00939] [EC:2.7.4.3]
100714720  Ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
102238515  Ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
100723741  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
100716835  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
100727971  Ntpcr; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
100727209  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100726931  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100720296  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2 [KO:K13293] [EC:3.1.4.53]
100302668  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3 [KO:K13293] [EC:3.1.4.53]
100716702  Pde4c; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
100135594  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
100720311  Pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
100527957  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
100302670  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
100722693  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
100735806  Fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
100728826  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
100135593  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100379231  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100733081  uricase [KO:K00365] [EC:1.7.3.3]
100719474  5-hydroxyisourate hydrolase-like isoform X1 [KO:K07127] [EC:3.5.2.17]
100725089  Allc; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cpoc00030  Pentose phosphate pathway
cpoc00220  Arginine biosynthesis
cpoc00250  Alanine, aspartate and glutamate metabolism
cpoc00260  Glycine, serine and threonine metabolism
cpoc00340  Histidine metabolism
cpoc00630  Glyoxylate and dicarboxylate metabolism
cpoc00730  Thiamine metabolism
cpoc00740  Riboflavin metabolism
cpoc00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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