KEGG   PATHWAY: cvg04145
Entry
cvg04145                    Pathway                                
Name
Phagosome - Cyprinodon variegatus (sheepshead minnow)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cvg04145  Phagosome
cvg04145

Other DBs
GO: 0045335
Organism
Cyprinodon variegatus (sheepshead minnow) [GN:cvg]
Gene
107083312  vamp3; vesicle-associated membrane protein 3 [KO:K13505]
107087958  stx12; syntaxin-12 [KO:K13813]
107088465  stx7; syntaxin-7 [KO:K08488]
107096517  actin, cytoplasmic 2 [KO:K05692]
107087176  actb; actin, cytoplasmic 1 [KO:K05692]
107084762  coronin-1A-like isoform X1 [KO:K13882]
107097290  stx18; syntaxin-18 [KO:K08492]
107089733  sec22b; vesicle-trafficking protein SEC22b isoform X1 [KO:K08517]
107104565  vesicle-trafficking protein SEC22b-A-like [KO:K08517]
107104175  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107104782  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107080783  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107086728  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107105054  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
107104312  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107104336  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107104338  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107101419  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107089589  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107089590  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107080775  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107086729  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107104337  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107101426  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107104917  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107080735  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107101424  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
107101425  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107080911  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
107097590  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
107097591  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
107097595  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
107097598  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
107097599  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
107104506  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
107104507  rano class II histocompatibility antigen, D-1 beta chain-like [KO:K06752]
107104508  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
107104679  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
107082207  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
107082220  rano class II histocompatibility antigen, B alpha chain-like [KO:K06752]
107082226  H-2 class II histocompatibility antigen, A-U alpha chain-like isoform X1 [KO:K06752]
107082239  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107104709  rano class II histocompatibility antigen, D-1 beta chain-like [KO:K06752]
107099835  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107099836  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
107104827  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
107104828  HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
107082990  ras-related protein Rab-5A-like [KO:K07887]
107083283  rab5a; ras-related protein Rab-5A [KO:K07887]
107102771  ras-related protein Rab-5B-like [KO:K07888]
107099752  ras-related protein Rab-5C [KO:K07889]
107099621  rab5c; ras-related protein Rab-5C [KO:K07889]
107104245  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
107085215  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
107094809  transferrin receptor protein 1-like [KO:K06503]
107083638  tfrc; transferrin receptor protein 1 [KO:K06503]
107100153  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
107104603  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
107097936  atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
107095095  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
107091111  atp6v1c2; V-type proton ATPase subunit C 2 [KO:K02148]
107090119  atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
107092448  V-type proton ATPase subunit C 1-A-like [KO:K02148]
107081136  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
107085735  V-type proton ATPase subunit E 1-like [KO:K02150]
107097962  atp6v1e1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
107101450  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
107098042  V-type proton ATPase subunit G 1-like [KO:K02152]
107086136  atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
107092696  V-type proton ATPase 116 kDa subunit a isoform 2-like [KO:K02154]
107091801  atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154]
107088230  V-type proton ATPase 116 kDa subunit a isoform 3-like isoform X1 [KO:K02154]
107087643  V-type proton ATPase 116 kDa subunit a isoform 1-like isoform X1 [KO:K02154]
107091251  V-type proton ATPase 116 kDa subunit a isoform 2-like [KO:K02154]
107083839  atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
107098297  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
107085016  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
107101194  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
107081727  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
107096767  atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
107093905  ras-related protein Rab-7a-like [KO:K07897]
107100231  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
107094022  rab7a; ras-related protein Rab-7a [KO:K07897]
107095006  RILP-like protein 1 [KO:K13883]
107091931  LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1-like [KO:K10414]
107091874  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
107085838  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
107104533  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
107101287  cytoplasmic dynein 1 light intermediate chain 1-like isoform X1 [KO:K10416]
107091014  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
107098580  tubulin alpha-1C chain-like [KO:K07374]
107101578  tubulin alpha chain-like isoform X1 [KO:K07374]
107088035  tubulin alpha chain isoform X1 [KO:K07374]
107088039  tubulin alpha chain-like [KO:K07374]
107096839  tuba4a; tubulin alpha-4A chain [KO:K07374]
107093978  tubulin alpha-1C chain-like [KO:K07374]
107095079  tubulin alpha-1B chain [KO:K07374]
107086463  tubulin alpha chain-like [KO:K07374]
107088737  tubulin alpha chain-like [KO:K07374]
107088747  tubulin alpha-1B chain-like [KO:K07374]
107094648  tubulin beta-4B chain-like isoform X1 [KO:K07375]
107098668  tubb4b; tubulin beta-4B chain [KO:K07375]
107103221  tubulin beta chain-like [KO:K07375]
107082212  tubulin beta chain isoform X1 [KO:K07375]
107086735  tubulin beta chain-like [KO:K07375]
107092425  tubulin beta chain-like [KO:K07375]
107102821  tubulin beta-5 chain [KO:K07375]
107100147  tubulin beta-4B chain-like [KO:K07375]
107082475  tubulin beta-4B chain-like [KO:K07375]
107093701  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
107088301  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
107099893  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
107097750  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
107082171  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
107087335  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
107099463  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
107099477  ctsl; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
107099482  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107080941  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107088057  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107096502  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107096503  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
107096509  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
107086772  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
107088360  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
107100419  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
107094024  sec61a1; protein transport protein Sec61 subunit alpha isoform 1 [KO:K10956]
107101088  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
107093952  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
107082986  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
107102461  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
107104435  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
107104823  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
107101296  calreticulin-like [KO:K08057]
107080670  calreticulin-like [KO:K08057]
107083799  canx; calnexin [KO:K08054]
107099292  uncharacterized protein LOC107099292 [KO:K06498]
107103197  putative high affinity immunoglobulin gamma Fc receptor IC [KO:K06498]
107081883  Fc receptor-like protein 5 [KO:K06498]
107104243  high affinity immunoglobulin gamma Fc receptor I-like [KO:K12560]
107105095  Fc receptor-like B [KO:K12560]
107104434  putative high affinity immunoglobulin gamma Fc receptor IC [KO:K06463]
107102744  Fc receptor-like protein 5 [KO:K06463]
107104144  high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06463]
107082193  complement C1r subcomponent-like [KO:K01330] [EC:3.4.21.41]
107102807  itgb2; integrin beta-2 [KO:K06464]
107102808  integrin beta-2-like [KO:K06464]
107082431  complement C3-like [KO:K03990]
107091326  colec11; collectin-11 [KO:K10066]
107099964  collectin-12-like isoform X1 [KO:K10062]
107086487  collectin-12-like [KO:K10062]
107098331  integrin alpha-V-like [KO:K06487]
107089697  itga2; integrin alpha-2 [KO:K06481]
107091914  integrin alpha-5-like [KO:K06484]
107097896  integrin alpha-5-like [KO:K06484]
107090367  itgb1; integrin beta-1 [KO:K05719]
107094308  integrin beta-1-like [KO:K05719]
107094704  itgb3; integrin beta-3 [KO:K06493]
107084752  integrin beta-3-like [KO:K06493]
107103227  integrin beta-5-like [KO:K06588]
107093665  thrombospondin-1-like [KO:K16857]
107084065  thrombospondin-1-like [KO:K16857]
107088988  thrombospondin-4-B-like [KO:K04659]
107098880  thbs4; thrombospondin-4 [KO:K04659]
107089296  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
107094435  thbs3; thrombospondin-3 [KO:K04659]
107085525  thrombospondin-2-like [KO:K04659]
107095193  thrombospondin-4-like [KO:K04659]
107082271  tlr2; toll-like receptor 2 [KO:K10159]
107082292  toll-like receptor 2 type-2 [KO:K10159]
107084756  toll-like receptor 2 type-2 isoform X1 [KO:K10159]
107082737  macrophage mannose receptor 1-like [KO:K06560]
107099956  macrophage mannose receptor 1-like [KO:K06560]
107082543  pla2r1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
107084812  mrc2; C-type mannose receptor 2 [KO:K06560]
107086503  mrc1; macrophage mannose receptor 1 [KO:K06560]
107085804  macrophage mannose receptor 1-like [KO:K06560]
107100082  marco; macrophage receptor MARCO [KO:K13884]
107102165  scarb1; scavenger receptor class B member 1 [KO:K13885]
107097424  cd36; platelet glycoprotein 4 [KO:K06259]
107084165  cytochrome b-245 light chain [KO:K08009]
107096819  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
107092536  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107090299  ncf1; neutrophil cytosol factor 1 [KO:K08011]
107084894  neutrophil cytosol factor 2-like [KO:K08010]
107090060  ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cvg04142  Lysosome
cvg04144  Endocytosis
cvg04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
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