KEGG   PATHWAY: dsp04144
Entry
dsp04144                    Pathway                                
Name
Endocytosis - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
dsp04144  Endocytosis
dsp04144

Other DBs
GO: 0006897
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122106461  Arf6; ADP-ribosylation factor 6 [KO:K07941]
122119559  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
122124655  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
122109212  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
122109020  Pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
122107290  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
122108633  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
122103686  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
122109044  Dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
122119818  Dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
122123836  Clta; clathrin light chain A [KO:K04644]
122096507  Cltb; clathrin light chain B isoform X1 [KO:K04645]
122118131  Cltc; LOW QUALITY PROTEIN: clathrin heavy chain 1 [KO:K04646]
122099950  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
122125716  Ap2a1; AP-2 complex subunit alpha-1 [KO:K11824]
122119749  Ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
122099411  Ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
122125756  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
122125820  Ehd2; EH domain-containing protein 2 [KO:K12469]
122121204  Tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
122096026  Tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122107631  Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
122117128  Zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
122123005  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
122104270  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
122114693  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
122096941  Tfrc; transferrin receptor protein 1 isoform X1 [KO:K06503]
122112209  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122106871  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122126852  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122100692  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122096494  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122123999  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122110362  Cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
122105546  Cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
122125696  Cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
122100104  Sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
122118937  Sh3gl2; endophilin-A1 [KO:K11247]
122099334  Sh3gl1; endophilin-A2 [KO:K11247]
122101468  Sh3gl3; LOW QUALITY PROTEIN: endophilin-A3 [KO:K11247]
122118303  Sh3glb1; endophilin-B1 isoform X1 [KO:K11248]
122109002  Sh3glb2; endophilin-B2 [KO:K21269]
122112380  Bin1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
122120853  Amph; amphiphysin [KO:K12562]
122103351  Epn3; epsin-3 isoform X1 [KO:K12471]
122110647  Epn1; epsin-1 isoform X1 [KO:K12471]
122103046  Epn2; epsin-2 isoform X1 [KO:K12471]
122103989  Eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
122100267  Eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
122112712  Spart; spartin [KO:K19366]
122106315  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K10591] [EC:2.3.2.26]
122114476  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
122104283  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
122124078  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122117775  Traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
122124142  Rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
122120175  Itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
122128374  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
122113841  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
122096724  Wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
122119822  Ldlr; low-density lipoprotein receptor [KO:K12473]
122115287  Ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
122116925  Dab2; disabled homolog 2 isoform X1 [KO:K12475]
122095631  C-C chemokine receptor type 5-like [KO:K04180]
122107404  C-X-C chemokine receptor type 1-like [KO:K04175]
122107411  C-X-C chemokine receptor type 2-like [KO:K05050]
122110827  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
122122879  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
122104916  Grk2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
122097920  Grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
122096515  Grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
122100679  Grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
122126856  Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
122114172  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
122108635  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
122121770  Wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612]
122117437  Actr2; actin-related protein 2 [KO:K17260]
122112319  Actr3; actin-related protein 3 [KO:K18584]
122105979  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
122113650  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
122113781  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
122107398  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
122115033  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
122124266  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
122098535  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
122107833  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
122103730  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
122107112  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
122112149  Wipf3; LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 3 [KO:K19475]
122120049  Wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
122102058  Wipf2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
122111476  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
122111513  heat shock 70 kDa protein 1-like [KO:K03283]
122110292  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
122111441  Dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
122119123  Washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
122102355  Washc5; WASH complex subunit 5 [KO:K18464]
122122377  WASH complex subunit 2A-like [KO:K18462]
122102532  Washc1; LOW QUALITY PROTEIN: WASH complex subunit 1 [KO:K18461]
122119304  Washc3; WASH complex subunit 3 isoform X1 [KO:K18463]
122118791  F-actin-capping protein subunit alpha-1-like [KO:K10364]
122104103  Capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
122121746  Capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
122102601  Capza3; F-actin-capping protein subunit alpha-3 [KO:K10364]
122115251  Capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
122098581  Vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
122125389  vacuolar protein sorting-associated protein 29-like [KO:K18467]
122125410  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 29-like [KO:K18467]
122126589  vacuolar protein sorting-associated protein 29-like [KO:K18467]
122104138  Vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
122122291  Vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
122096843  Vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
122120650  Snx12; sorting nexin-12 [KO:K17918]
122126586  Snx3; sorting nexin-3 [KO:K17918]
122114596  Usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
122125203  STAM-binding protein [KO:K11866] [EC:3.4.19.12]
122099837  Rab7a; ras-related protein Rab-7a [KO:K07897]
122099398  Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
122110781  Stam2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
122113124  Stam; signal transducing adapter molecule 1 [KO:K04705]
122117645  Tsg101; tumor susceptibility gene 101 protein [KO:K12183]
122100850  Mvb12a; LOW QUALITY PROTEIN: multivesicular body subunit 12A [KO:K12186]
122109060  Mvb12b; multivesicular body subunit 12B isoform X1 [KO:K12186]
122098914  Vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
122127563  Vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
122105235  Vps37c; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
122098602  Vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
122114882  Vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
122100743  Snf8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
122112573  Vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
122101019  Vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
122099363  Chmp6; charged multivesicular body protein 6 [KO:K12195]
122120434  Chmp4b; charged multivesicular body protein 4b [KO:K12194]
122113412  Chmp4a; charged multivesicular body protein 4a isoform X1 [KO:K12194]
122108666  Chmp4c; charged multivesicular body protein 4c [KO:K24782]
122116629  charged multivesicular body protein 3 [KO:K12193]
122110703  Chmp2a; charged multivesicular body protein 2a [KO:K12191]
122105641  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
122123503  Chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
122119435  Vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196]
122126191  Vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
122111182  Vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
122110947  Chmp1b; charged multivesicular body protein 1b [KO:K12197]
122127933  Chmp1a; charged multivesicular body protein 1a [KO:K12197]
122123510  Chmp5; charged multivesicular body protein 5 [KO:K12198]
122126128  Ist1; IST1 homolog isoform X1 [KO:K19476]
122096126  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
122114660  Spg21; maspardin [KO:K19367]
122116120  Igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
122103716  Snx2; sorting nexin-2 [KO:K17917]
122114449  Snx1; sorting nexin-1 [KO:K17917]
122096011  Snx5; sorting nexin-5 [KO:K17920]
122112387  LOW QUALITY PROTEIN: sorting nexin-6-like [KO:K17920]
122106489  Snx6; sorting nexin-6 isoform X1 [KO:K17920]
122120491  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
122095011  Hras; GTPase HRas isoform X1 [KO:K02833]
122113142  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
122119318  Il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
122120620  Il2rg; LOW QUALITY PROTEIN: cytokine receptor common subunit gamma [KO:K05070]
122095683  Rhoa; transforming protein RhoA [KO:K04513]
122115017  transforming protein RhoA-like [KO:K04513]
122111313  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
122111314  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
122111316  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
122111318  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111319  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111320  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111321  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
122111322  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
122111324  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111325  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111326  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122115723  folate receptor alpha-like [KO:K13649]
122115743  Folr2; folate receptor beta isoform X1 [KO:K13649]
122121830  Cav1; caveolin-1 isoform X1 [KO:K06278]
122121810  Cav2; caveolin-2 [KO:K12958]
122108190  Cav3; caveolin-3 [KO:K12959]
122122478  Ehd3; EH domain-containing protein 3 [KO:K12476]
122114620  Ehd4; EH domain-containing protein 4 [KO:K12477]
122119113  Eea1; early endosome antigen 1 isoform X1 [KO:K12478]
122108082  Rab5a; ras-related protein Rab-5A [KO:K07887]
122124350  Rab5b; ras-related protein Rab-5B [KO:K07888]
122103267  Rab5c; ras-related protein Rab-5C [KO:K07889]
122100607  ras-related protein Rab-5C-like [KO:K07889]
122108641  Rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
122108202  Rbsn; rabenosyn-5 [KO:K12481]
122113106  Rab4a; ras-related protein Rab-4A [KO:K07879]
122122296  Rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
122115469  Rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
122105133  Ehd1; EH domain-containing protein 1 [KO:K12483]
122109295  Vps45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
122098152  Snx4; sorting nexin-4 [KO:K17919]
122110962  Rab31; ras-related protein Rab-31 [KO:K07891]
122124569  Rab22a; ras-related protein Rab-22A isoform X1 [KO:K07891]
122108737  ras-related protein Rab-31-like [KO:K07891]
122122439  Rab10; ras-related protein Rab-10 [KO:K07903]
122100842  Rab8a; ras-related protein Rab-8A [KO:K07901]
122099040  Rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
122114459  Rab11a; ras-related protein Rab-11A [KO:K07904]
122119785  Rab11b; ras-related protein Rab-11B [KO:K07905]
122125227  Rab11fip5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
122126815  Rab11fip2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
122126995  Rab11fip1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
122115890  Zfyve27; protrudin [KO:K19368]
122110785  Kif5c; kinesin heavy chain [KO:K10396]
122113307  Kif5b; kinesin-1 heavy chain [KO:K10396]
122124175  Kif5a; kinesin heavy chain [KO:K10396]
122098145  Rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
122117724  Rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
122113067  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
122097754  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
122124626  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
122126269  Pard6a; partitioning defective 6 homolog alpha [KO:K06093]
122127324  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
122107248  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
122119115  cell division control protein 42 homolog [KO:K04393]
122115178  Cdc42; cell division control protein 42 homolog [KO:K04393]
122105868  Smap2; stromal membrane-associated protein 2 [KO:K12486]
122113944  Smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
122117490  Git1; ARF GTPase-activating protein GIT1 [KO:K05737]
122099006  Git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
122115180  Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
122108769  Asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
122125316  Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
122127355  Acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
122099618  Acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
122100385  Acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
122115212  Arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
122106743  Arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
122118187  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
122105916  Agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
122107218  Agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
122124024  Agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
122101796  Arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
122105355  Arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
122123618  Arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
122115753  Psd; PH and SEC7 domain-containing protein 1 [KO:K12494]
122100602  Psd4; PH and SEC7 domain-containing protein 4 [KO:K12494]
122118178  Psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
122112067  Iqsec2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
122107839  Iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
122101696  Iqsec3; IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
122102533  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3-like [KO:K12495]
122119293  Cyth4; cytohesin-4 [KO:K18441]
122096598  Cyth1; cytohesin-1 [KO:K18441]
122113599  Cyth3; cytohesin-3 [KO:K18441]
122125868  Cyth2; cytohesin-2 [KO:K18441]
122127887  Arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
122095992  Arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
122115737  Gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
122103291  Arl17a; ADP-ribosylation factor-like 17-like isoform X1 [KO:K07937]
122120604  ADP-ribosylation factor 1-like [KO:K07937]
122098931  Arf1; ADP-ribosylation factor 1 [KO:K07937]
122106155  Arf3; ADP-ribosylation factor 3 [KO:K07938]
122108228  Arf4; ADP-ribosylation factor 4 [KO:K07939]
122121792  Arf5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
dsp04060  Cytokine-cytokine receptor interaction
dsp04070  Phosphatidylinositol signaling system
dsp04130  SNARE interactions in vesicular transport
dsp04142  Lysosome
dsp04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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