Entry Name Axon guidance - Equus asinus (ass)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Equus asinus (ass) [GN:
eai ]
Gene 106834358 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
106838128 TRPC1; short transient receptor potential channel 1 isoform X2 [KO:K04964 ]
106834075 TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
106847712 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
106834431 PPP3CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
106842388 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348 ] [EC:3.1.3.16 ]
106825560 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
106822461 NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
106848610 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
106840518 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
106837585 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
106846070 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
106840004 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
106840067 ABLIM2; LOW QUALITY PROTEIN: actin-binding LIM protein 2 [KO:K07520 ]
106836515 myosin regulatory light chain 2, smooth muscle major isoform-like [KO:K12755 ]
106842382 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
106828581 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
106830727 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X2 [KO:K04630 ]
106827362 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
106833450 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
106824390 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
106841768 SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X7 [KO:K07526 ]
106823407 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X4 [KO:K07526 ]
106837019 DPYSL5; dihydropyrimidinase-related protein 5 isoform X2 [KO:K07529 ]
106834009 DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
106843233 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
106843543 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
106822866 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
106838495 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
106838100 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
106829313 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
106836695 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
106840141 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
106822593 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
106824993 PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
106822510 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related eai04060 Cytokine-cytokine receptor interaction
eai04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
