KEGG   PATHWAY: etl04820
Entry
etl04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Empidonax traillii (willow flycatcher)
Class
Cellular Processes; Cell motility
Pathway map
etl04820  Cytoskeleton in muscle cells
etl04820

Organism
Empidonax traillii (willow flycatcher) [GN:etl]
Gene
114069045  COL1A1; collagen alpha-1(I) chain [KO:K06236]
114072794  COL1A2; collagen alpha-2(I) chain [KO:K06236]
114057768  COL3A1; collagen alpha-1(III) chain [KO:K19720]
114064641  basic proline-rich protein-like [KO:K19720]
114054560  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
114057769  COL5A2; collagen alpha-2(V) chain [KO:K19721]
114071175  collagen alpha-1(I) chain-like [KO:K19721]
114059106  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
114057103  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
114061670  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
114056393  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
114069279  collagen alpha-2(IX) chain-like [KO:K08131]
114071538  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
114070608  collagen alpha-1(IX) chain-like [KO:K08131]
114067608  DCN; decorin isoform X1 [KO:K04660]
114056226  VCAN; versican core protein isoform X1 [KO:K06793]
114069880  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
114068090  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
114068099  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
114064280  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
114063733  THBS1; thrombospondin-1 [KO:K16857]
114073186  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
114056830  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
114067663  THBS2; thrombospondin-2 [KO:K04659]
114059922  FBN1; fibrillin-1 isoform X1 [KO:K06825]
114063871  fibrillin-2 [KO:K23342]
114068843  fibrillin-2-like isoform X1 [KO:K23342]
114059691  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
114068748  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
114059817  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
114066308  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
114059824  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
114065833  collagen alpha-6(IV) chain-like [KO:K06237]
114070034  FBLN1; fibulin-1 isoform X1 [KO:K17307]
114067658  FBLN2; fibulin-2 [KO:K17307]
114068791  NID2; nidogen-2 [KO:K06826]
114065884  NID1; nidogen-1 isoform X1 [KO:K06826]
114060672  FN1; fibronectin isoform X1 [KO:K05717]
114064997  SDC1; syndecan-1 isoform X1 [KO:K06257]
114060071  SDC2; syndecan-2 [KO:K16336]
114070258  SDC3; syndecan-3 [KO:K16337]
114058099  SDC4; syndecan-4 [KO:K16338]
114071021  agrin isoform X1 [KO:K06254]
114057194  DSG2; desmoglein-2 [KO:K07597]
114062602  PKP2; plakophilin-2 [KO:K12642]
114071840  JUP; junction plakoglobin [KO:K10056]
114064373  DSP; desmoplakin isoform X1 [KO:K10381]
114066706  VIM; vimentin [KO:K07606]
114055050  DES; desmin [KO:K07610]
114056678  LAMA1; laminin subunit alpha-1 [KO:K05637]
114055925  LAMA2; laminin subunit alpha-2 [KO:K05637]
114072612  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
114072581  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
114071998  ITGA2B; integrin alpha-IIb [KO:K06476]
114069038  ITGA3; integrin alpha-3 [KO:K06482]
114055780  ITGA4; integrin alpha-4 [KO:K06483]
114054920  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
114070096  ITGA7; integrin alpha-7 [KO:K06583]
114066138  ITGA9; integrin alpha-9 [KO:K06585]
114072101  ITGA10; integrin alpha-10 [KO:K06586]
114070862  integrin alpha-11-like [KO:K06587]
114059422  ITGAV; integrin alpha-V [KO:K06487]
114059485  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
114066945  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
114063396  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
114058115  ITGB5; integrin beta-5 [KO:K06588]
114054917  ITGB6; integrin beta-6 [KO:K06589]
114054615  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
114070059  TLN1; talin-1 [KO:K06271]
114069158  talin-2 isoform X1 [KO:K06271]
114063678  VCL; vinculin isoform X1 [KO:K05700]
114065877  ACTN2; alpha-actinin-2 [KO:K21073]
114068207  ACTG1; actin, cytoplasmic 2 [KO:K05692]
114059764  actin, cytoplasmic type 5 [KO:K05692]
114060184  ACTB; actin, cytoplasmic 1 [KO:K05692]
114071511  actin, gamma-enteric smooth muscle [KO:K12315]
114058766  DAG1; dystroglycan [KO:K06265]
114069044  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
114072841  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
114065582  SGCB; beta-sarcoglycan [KO:K12566]
114058329  SGCD; delta-sarcoglycan [KO:K12563]
114057674  SGCG; gamma-sarcoglycan [KO:K12564]
114058326  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
114064991  SSPN; sarcospan [KO:K22194]
114059455  DMD; dystrophin isoform X1 [KO:K10366]
114057275  SNTA1; alpha-1-syntrophin [KO:K24063]
114067943  SNTB2; beta-2-syntrophin isoform X1 [KO:K24064]
114057989  SNTB1; beta-1-syntrophin [KO:K24064]
114060606  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
114072022  filamin-C-like [KO:K27393]
114055106  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
114064576  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
114068736  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
114064932  ATP1B4; protein ATP1B4 [KO:K01540]
114064869  ANK3; ankyrin-3 isoform X1 [KO:K09259]
114054531  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
114064839  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
114056497  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
114058924  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
114069312  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
114064766  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
114057260  MYH7B; myosin-7B [KO:K24220]
114057219  MYH15; myosin-15 isoform X1 [KO:K24220]
114065657  myosin-1B [KO:K24220]
114067601  myosin-3-like [KO:K24220]
114072520  myosin-6 [KO:K17751]
114055155  myosin-7 [KO:K17751]
114055158  myosin-7-like [KO:K17751]
114055435  MYH9; myosin-9 [KO:K10352]
114058251  MYH11; myosin-11 isoform X1 [KO:K10352]
114064109  MYH10; myosin-10 isoform X1 [KO:K10352]
114059421  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
114071430  myosin light chain 1, cardiac muscle [KO:K12749]
114066937  myosin light chain, embryonic [KO:K12750]
114062679  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
114059723  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
114056157  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
114058800  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
114067005  ACTA1; actin, alpha skeletal muscle [KO:K10354]
114055305  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
114061281  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
114064767  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
114063063  TNNC2; troponin C, skeletal muscle [KO:K12042]
114059850  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
114059847  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
114064765  TNNT2; troponin T, cardiac muscle [KO:K12045]
114069160  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
114069776  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
114068572  tropomyosin beta chain-like isoform X1 [KO:K10374]
114068434  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
114067119  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
114064038  TTN; titin [KO:K12567] [EC:2.7.11.1]
114055692  titin-like [KO:K12567] [EC:2.7.11.1]
114061730  MYOT; myotilin [KO:K19875]
114071803  TCAP; telethonin [KO:K19879]
114059013  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
114070746  NEB; nebulin [KO:K18267]
114073019  nebulin-like [KO:K18267]
114072072  nebulin-like [KO:K18267]
114059319  NEBL; nebulette isoform X1 [KO:K25865]
114058133  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
114059015  MYOZ2; myozenin-2 [KO:K26050]
114065608  MYOZ3; myozenin-3 [KO:K26050]
114055567  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
114070080  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
114065364  PDLIM1; PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
114065709  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
114062353  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
114063120  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
114066859  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
114069655  xin actin-binding repeat-containing protein 1-like isoform X1 [KO:K27381]
114066969  NRAP; nebulin-related-anchoring protein [KO:K24421]
114064012  MYPN; myopalladin [KO:K22028]
114066217  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
114063590  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
114064807  PDLIM5; PDZ and LIM domain protein 5 [KO:K19867]
114063852  PDZ and LIM domain protein 7-like [KO:K19867]
114071633  TMOD4; tropomodulin-4 [KO:K10370]
114057886  TMOD1; tropomodulin-1 [KO:K10370]
114057151  TMOD3; tropomodulin-3 [KO:K10370]
114057152  tropomodulin-2 [KO:K10370]
114065695  ZYX; LOW QUALITY PROTEIN: zyxin [KO:K06273]
114065629  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
114061798  FHL2; four and a half LIM domains protein 2 [KO:K14380]
114058888  FHL3; four and a half LIM domains protein 3 isoform X1 [KO:K24414]
114062847  LMOD2; leiomodin-2 isoform X1 [KO:K22030]
114072218  LMOD1; leiomodin-1 [KO:K22030]
114063096  LMOD3; leiomodin-3 [KO:K22030]
114065746  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
114070754  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
114067458  FMNL2; formin-like protein 2 [KO:K23957]
114070443  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
114066720  INF2; inverted formin-2 isoform X1 [KO:K23958]
114065195  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
114069010  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
114056039  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
114061944  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
114063480  FMN2; formin-2 [KO:K02184]
114058730  MYOM1; myomesin-1 isoform X1 [KO:K24495]
114065552  MYOM2; myomesin-2 [KO:K24495]
114067756  MYOM3; myomesin-3 [KO:K24495]
114058171  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
114056870  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
114069534  ANK2; ankyrin-2 isoform X1 [KO:K09255]
114069991  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
114062808  TRIM55; tripartite motif-containing protein 55 [KO:K10654]
114070344  TRIM63; E3 ubiquitin-protein ligase TRIM63 isoform X1 [KO:K10655] [EC:2.3.2.27]
114064398  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
114057796  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
114064497  OBSCN; obscurin [KO:K17531] [EC:2.7.11.1]
114056480  CAPN3; calpain-3 [KO:K08573] [EC:3.4.22.54]
114070855  PLEC; plectin [KO:K10388]
114061893  SYNE3; nesprin-3 [KO:K21761]
114069850  nesprin-1-like isoform X1 [KO:K19326]
114068035  SYNE1; nesprin-1 isoform X1 [KO:K19326]
114063209  SYNE2; nesprin-2 [KO:K19346]
114055372  SUN2; SUN domain-containing protein 2 [KO:K19347]
114054754  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
114056961  TMEM43; transmembrane protein 43 isoform X1 [KO:K27488]
114073700  LBR; lamin-B receptor isoform X1 [KO:K19532] [EC:1.3.1.70]
114069941  LMNA; lamin [KO:K12641]
114065556  LMNB2; lamin-B2 [KO:K07611]
114057121  LMNB1; lamin-B1 [KO:K07611]
114059050  lamin-L(III)-like isoform X1 [KO:K07611]
Reference
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
etl04512  ECM-receptor interaction
etl04814  Motor proteins
KO pathway
ko04820   
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