KEGG   PATHWAY: gste04060
Entry
gste04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Gavia stellata (red-throated loon)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
gste04060  Cytokine-cytokine receptor interaction
gste04060

Organism
Gavia stellata (red-throated loon) [GN:gste]
Gene
104264067  CCL1; C-C motif chemokine 1 [KO:K05514]
104262228  C-C motif chemokine 19-like [KO:K05512]
104258534  C-C motif chemokine 4-like [KO:K12964]
104264740  C-C motif chemokine 4 homolog isoform X1 [KO:K12964]
104261014  C-C motif chemokine 5-like [KO:K21083]
104252481  CCL5; C-C motif chemokine 5 [KO:K12499]
104252444  CCL20; C-C motif chemokine 20 [KO:K14625]
104254402  interleukin-8-like [KO:K10030]
104259682  interleukin-8-like [KO:K10030]
104259683  interleukin-8 [KO:K10030]
104259687  interleukin-8-like [KO:K10030]
104256443  interleukin-8-like [KO:K10032]
104262394  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104253514  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
104256494  lymphotactin-like [KO:K05507]
104261013  flocculation protein FLO11-like [KO:K05508]
104256903  interleukin-15-like [KO:K05429]
104252592  interleukin-7-like [KO:K05431]
104263758  uncharacterized protein LOC104263758 [KO:K05432]
104251919  IL15; interleukin-15 [KO:K05433]
104262856  interleukin-5-like [KO:K05428]
104258294  somatotropin isoform X1 [KO:K05438]
104254111  PRL; prolactin [KO:K05439]
104261381  THPO; thrombopoietin [KO:K06854]
104260245  IL12B; interleukin-12 subunit beta [KO:K05425]
104253454  IL10; LOW QUALITY PROTEIN: interleukin-10 [KO:K05443]
104253455  interleukin-20-like [KO:K22667]
104260556  IL22; interleukin-22 [KO:K05445]
104255408  interferon epsilon-like [KO:K05414]
104256440  IFNG; interferon gamma [KO:K04687]
104252302  IL18; interleukin-18 isoform X1 [KO:K05482]
104252705  interleukin-17F-like [KO:K05489]
104256932  interleukin-17F-like [KO:K05494]
104254457  IL17D; interleukin-17D [KO:K05492]
104262825  IL16; pro-interleukin-16 [KO:K22628]
104256136  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104262491  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104259523  tumor necrosis factor ligand superfamily member 15-like [KO:K05478]
104261974  TNFSF10; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104258330  NGF; beta-nerve growth factor [KO:K02582]
104257775  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
104250457  tumor necrosis factor ligand superfamily member 8-like [KO:K05471]
104262003  CD40LG; CD40 ligand [KO:K03161]
104263731  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
104262628  TGFB2; transforming growth factor beta-2 [KO:K13376]
104251892  TGFB3; transforming growth factor beta-3 [KO:K13377]
104252811  GDF2; growth/differentiation factor 2 [KO:K05503]
104257827  BMP10; bone morphogenetic protein 10 [KO:K22670]
104259886  BMP3; bone morphogenetic protein 3 [KO:K05496]
104252947  GDF10; bone morphogenetic protein 3B [KO:K22674]
104256078  MSTN; growth/differentiation factor 8 isoform X1 [KO:K05497]
104262777  INHBA; inhibin beta A chain [KO:K04667]
104261807  INHBB; inhibin beta B chain [KO:K22687]
104255446  GDF9; growth/differentiation factor 9 [KO:K22673]
104260116  inhibin beta C chain-like [KO:K22688]
104263531  inhibin beta C chain-like [KO:K22689]
104259056  bone morphogenetic protein 2-like [KO:K21283]
104257000  bone morphogenetic protein 7-like [KO:K21283]
104252596  GDF5; growth/differentiation factor 5 [KO:K04664]
104255898  BMP5; bone morphogenetic protein 5 [KO:K04663]
104259646  bone morphogenetic protein 6-like [KO:K16620]
104260120  BMP7; bone morphogenetic protein 7 [KO:K16621]
104257969  C-C chemokine receptor type 8-like [KO:K04183]
104253450  C-C chemokine receptor type 8-like [KO:K04183]
104255675  C-C chemokine receptor type 9-like [KO:K04184]
104264822  ACKR4; atypical chemokine receptor 4 [KO:K04186]
104262870  CCR7; C-C chemokine receptor type 7 [KO:K04182]
104254312  CCR4; C-C chemokine receptor type 4 [KO:K04179]
104250526  C-C chemokine receptor type 5-like [KO:K04180]
104254773  CCR6; C-C chemokine receptor type 6 [KO:K04181]
104262164  C-X-C chemokine receptor type 2-like [KO:K05050]
104253562  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
104253161  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104262718  ACKR3; atypical chemokine receptor 3 [KO:K04304]
104257622  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
104261411  XCR1; chemokine XC receptor 1 [KO:K04193]
104254319  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104257851  interleukin-2 receptor subunit alpha-like [KO:K05068]
104260064  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
104256893  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
104264862  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
104264101  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
104250492  IL21R; interleukin-21 receptor [KO:K05075]
104254578  cytokine receptor-like factor 2 [KO:K05078]
104259240  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
104254564  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104252858  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104260175  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
104258449  IL13RA2; LOW QUALITY PROTEIN: interleukin-13 receptor subunit alpha-2 [KO:K05077]
104265036  GHR; growth hormone receptor [KO:K05080]
104260897  PRLR; prolactin receptor isoform X1 [KO:K05081]
104264427  LEPR; leptin receptor [KO:K05062]
104251240  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
104259002  interleukin-31 receptor subunit alpha-like [KO:K22630]
104263328  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
104262932  LIFR; leukemia inhibitory factor receptor [KO:K05058]
104259714  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
104252533  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
104254685  interleukin-20 receptor subunit alpha-like [KO:K05136]
104257394  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
104255535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
104252921  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
104264539  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
104252480  IFNGR2; interferon gamma receptor 2 [KO:K05133]
104250733  IL1RL2; interleukin-1 receptor-like 2 [KO:K04386]
104257084  LOW QUALITY PROTEIN: interleukin-1 receptor accessory protein-like [KO:K04723]
104260488  interleukin-1 receptor type 2-like [KO:K04387]
104259471  IL1R1; interleukin-1 receptor type 1 [KO:K05172]
104262813  IL18R1; interleukin-18 receptor 1 [KO:K05173]
104256671  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
104263604  interleukin-1 receptor-like 1 [KO:K05171]
104264607  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
104251158  IL17RA; interleukin-17 receptor A [KO:K05164]
104256801  T-cell surface glycoprotein CD4-like [KO:K06454]
104258671  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104256345  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104260313  TNFRSF6B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B [KO:K05143]
104254442  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
104258706  TNFRSF10B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 10B [KO:K04722]
104256668  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
104260995  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
104259450  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
104255541  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
104252404  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
104253316  tumor necrosis factor receptor superfamily member 8-like [KO:K05145]
104264236  CD40; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 5 [KO:K03160]
104259724  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
104259725  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
104264840  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
104256905  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
104258780  RELL2; RELT-like protein 2 [KO:K26541]
104250840  RELL1; RELT-like protein 1 [KO:K26541]
104262739  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104260041  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104257506  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104255206  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
104251324  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104257441  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
104260065  ACVR1B; LOW QUALITY PROTEIN: activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
104262801  activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
104251879  activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
104263020  BMPR1A; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
104262135  bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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