KEGG   PATHWAY: hai04148
Entry
hai04148                    Pathway                                
Name
Efferocytosis - Hipposideros armiger (great roundleaf bat)
Class
Cellular Processes; Transport and catabolism
Pathway map
hai04148  Efferocytosis
hai04148

Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109395706  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
109384919  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
109377701  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
109390556  PANX1; pannexin-1 [KO:K03443]
109386367  P2RY2; P2Y purinoceptor 2 [KO:K04269]
109386374  P2RY6; P2Y purinoceptor 6 [KO:K04272]
109373049  LOW QUALITY PROTEIN: P2Y purinoceptor 3-like [KO:K04272]
109392700  P2RY12; P2Y purinoceptor 12 [KO:K04298]
109391059  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
109383749  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
109371358  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
109371278  ABCA1; ATP-binding cassette sub-family A member 1 isoform X1 [KO:K05641]
109381007  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
109386655  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
109390694  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
109395633  CX3CL1; fractalkine [KO:K05508]
109393464  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
109381836  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
109383198  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109389408  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109393596  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
109383747  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
109372278  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
109374918  EPO; erythropoietin [KO:K05437]
109391584  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
109384506  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109381855  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
109384577  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
109381229  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
109377712  MFGE8; lactadherin isoform X1 [KO:K17253]
109383952  GAS6; growth arrest-specific protein 6 [KO:K05464]
109393537  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
109392891  CD36; platelet glycoprotein 4 [KO:K06259]
109384080  THBS1; thrombospondin-1 [KO:K16857]
109385252  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109388626  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109379092  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
109384486  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
109376163  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
109384340  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
109388316  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109376590  TGFB1; transforming growth factor beta-1 [KO:K13375]
109385859  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
109391912  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
109386055  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
109372542  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109373019  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109375001  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109390284  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109395979  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109395980  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396629  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396630  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109374513  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
109389501  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
109394595  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
109387249  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109384920  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109383157  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109395932  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109375840  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109392025  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109388391  ANO6; anoctamin-6 [KO:K19500]
109373322  ANO3; anoctamin-3 isoform X1 [KO:K19498]
109377598  anoctamin-4-like [KO:K19499]
109387453  ANO5; anoctamin-5 [KO:K19480]
109374781  ANO7; anoctamin-7 [KO:K19501]
109375625  ANO9; anoctamin-9 [KO:K19503]
109390655  BSG; basigin isoform X1 [KO:K06535]
109386685  XKR8; XK-related protein 8 [KO:K26813]
109372622  XKR9; XK-related protein 9 [KO:K26814]
109384410  XKR7; XK-related protein 7 [KO:K26811]
109379510  XKR6; XK-related protein 6 [KO:K26811]
109394457  XKR4; XK-related protein 4 [KO:K26811]
109374158  ATP8A1; phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
109387513  ATP8A2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
109383943  ATP11A; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
109388679  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
109396385  ATP11B; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
109387560  TMEM30A; cell cycle control protein 50A [KO:K26935]
109375938  PROS1; vitamin K-dependent protein S [KO:K03908]
109372713  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
109380323  ITGB3; integrin beta-3 [KO:K06493]
109387967  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
109376603  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
109384085  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
109390823  ADGRB1; brain-specific angiogenesis inhibitor 1 [KO:K04596]
109388895  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 isoform X1 [KO:K26936]
109371509  LOW QUALITY PROTEIN: hepatitis A virus cellular receptor 1 homolog [KO:K20413]
109388893  hepatitis A virus cellular receptor 1 homolog [KO:K20413]
109388907  HAVCR2; hepatitis A virus cellular receptor 2 isoform X1 [KO:K20414]
109373121  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
109373881  STAB1; stabilin-1 [KO:K19020]
109387774  STAB2; stabilin-2 [KO:K19013]
109390857  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109384807  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
109386906  CRK; adapter molecule crk isoform X1 [KO:K04438]
109376239  CRKL; crk-like protein [KO:K04438]
109389817  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
109389001  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109373152  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 isoform X1 [KO:K06834] [EC:3.4.24.-]
109394224  CALR; calreticulin [KO:K08057]
109376402  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
109396736  C1QA; complement C1q subcomponent subunit A isoform X1 [KO:K03986]
109396733  C1QB; complement C1q subcomponent subunit B [KO:K03987]
109396734  C1QC; complement C1q subcomponent subunit C [KO:K03988]
109390725  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
109379031  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
109385257  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
109386893  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
109372697  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
109373845  RAB17; ras-related protein Rab-17 [KO:K07909]
109393991  RAB5A; ras-related protein Rab-5A [KO:K07887]
109396876  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
109395780  RAB5C; ras-related protein Rab-5C [KO:K07889]
109373394  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
109396809  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
109393906  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
109384407  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
109384086  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
109386071  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
109385729  RAB14; ras-related protein Rab-14 [KO:K07881]
109384079  VPS39; vam6/Vps39-like protein [KO:K20183]
109375590  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
109377415  RAB7A; ras-related protein Rab-7a [KO:K07897]
109386465  RAB7B; ras-related protein Rab-7b [KO:K07898]
109395583  PQLC2; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
109382070  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
109393845  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
109390755  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109386673  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
109377127  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
109390175  oxysterols receptor LXR-alpha [KO:K08536]
109391085  NR1H2; oxysterols receptor LXR-beta [KO:K08535]
109389301  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
109396636  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
109391119  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
109383030  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
109371987  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
109392313  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
109374504  IL10; interleukin-10 [KO:K05443]
109377125  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
109389511  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
109392458  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
109383412  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
109391550  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
109371924  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
109387352  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
109380317  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
109377736  SIGLEC10; sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
109384353  signal-regulatory protein beta-1-like [KO:K06551]
109384370  signal-regulatory protein beta-1-like [KO:K06551]
109384417  signal-regulatory protein beta-1-like isoform X1 [KO:K06551]
109384418  signal-regulatory protein beta-1-like isoform X1 [KO:K06551]
109384419  signal-regulatory protein beta-1-like isoform X1 [KO:K06551]
109384421  signal-regulatory protein beta-1-like isoform X1 [KO:K06551]
109384431  SIRPA; tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551]
109373664  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
109382264  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
109391216  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
hai00010  Glycolysis / Gluconeogenesis
hai04140  Autophagy - animal
hai04145  Phagosome
KO pathway
ko04148   
LinkDB

DBGET integrated database retrieval system