KEGG   PATHWAY: hhv04144
Entry
hhv04144                    Pathway                                
Name
Endocytosis - Hyaena hyaena (striped hyena)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
hhv04144  Endocytosis
hhv04144

Other DBs
GO: 0006897
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120220270  ARF6; ADP-ribosylation factor 6 [KO:K07941]
120243401  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
120241303  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
120242042  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
120230176  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
120226705  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
120234597  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
120230108  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
120223949  dynamin-3 [KO:K01528] [EC:3.6.5.5]
120244419  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
120233503  CLTA; clathrin light chain A isoform X1 [KO:K04644]
120236787  CLTB; clathrin light chain B isoform X1 [KO:K04645]
120238835  CLTCL1; clathrin heavy chain 2 [KO:K04646]
120241917  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
120243961  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
120223407  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
120224387  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
120219720  LOW QUALITY PROTEIN: AP-2 complex subunit beta-like [KO:K11825]
120238096  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
120243829  AP2S1; AP-2 complex subunit sigma [KO:K11827]
120243697  EHD2; EH domain-containing protein 2 [KO:K12469]
120233513  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120224680  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120235957  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
120242008  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
120235727  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
120229672  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
120221278  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
120244375  TFRC; transferrin receptor protein 1 [KO:K06503]
120238884  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120222584  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120244115  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120231844  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120236775  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120233674  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
120229982  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
120239104  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
120243253  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
120241965  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
120237548  SH3GL2; endophilin-A1 [KO:K11247]
120219612  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
120242075  SH3GL1; endophilin-A2 [KO:K11247]
120247718  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
120230149  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
120225670  AMPH; amphiphysin [KO:K12562]
120245947  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
120228741  EPN2; epsin-2 isoform X1 [KO:K12471]
120239715  EPN1; epsin-1 isoform X1 [KO:K12471]
120229022  EPN3; epsin-3 isoform X1 [KO:K12471]
120225674  epidermal growth factor receptor substrate 15-like [KO:K12472]
120239184  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
120235728  epidermal growth factor receptor substrate 15-like [KO:K12472]
120245017  SPART; spartin isoform X1 [KO:K19366]
120219708  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
120230765  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
120234269  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
120240795  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
120232555  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120219908  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
120242777  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
120234211  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
120227976  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
120225202  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
120244466  LDLR; low-density lipoprotein receptor [KO:K12473]
120231848  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
120239781  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
120229184  C-C chemokine receptor type 5-like [KO:K04180]
120232399  C-X-C chemokine receptor type 2-like [KO:K04175]
120232444  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
120230386  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
120223471  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
120242660  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
120233906  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
120227230  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
120235181  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
120231805  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
120236759  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
120226697  ARRB2; beta-arrestin-2 [KO:K04439]
120229571  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
120236728  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
120239055  ACTR2; actin-related protein 2 [KO:K17260]
120230365  ACTR3; actin-related protein 3 [KO:K18584]
120230918  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
120227999  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120228025  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
120232413  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
120247985  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
120231303  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
120236302  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
120245834  actin-related protein 2/3 complex subunit 5 [KO:K05754]
120245840  protein diaphanous homolog 1-like [KO:K05754]
120239060  phosphatase and actin regulator 4A-like [KO:K19475]
120229059  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
120230128  basic salivary proline-rich protein 2-like [KO:K19475]
120230333  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
120236423  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
120227766  heat shock 70 kDa protein 1 [KO:K03283]
120220580  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
120240081  heat shock cognate 71 kDa protein-like [KO:K03283]
120221892  heat shock 70 kDa protein 1-like [KO:K03283]
120221893  heat shock 70 kDa protein 1 [KO:K03283]
120221952  heat shock cognate 71 kDa protein-like [KO:K03283]
120241045  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
120249032  heat shock cognate 71 kDa protein-like [KO:K03283]
120232594  DNAJC6; putative tyrosine-protein phosphatase auxilin [KO:K09526]
120245721  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
120231754  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
120232785  WASHC2A; WASH complex subunit 2A isoform X1 [KO:K18462]
120234492  WASHC1; WASH complex subunit 1 [KO:K18461]
120245440  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
120243008  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
120223827  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
120247132  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
120229791  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
120219980  vacuolar protein sorting-associated protein 29-like [KO:K18467]
120245140  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
120232498  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
120246316  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
120238075  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
120235210  SNX3; sorting nexin-3 [KO:K17918]
120246051  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
120235004  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
120237024  STAM-binding protein [KO:K11866] [EC:3.4.19.12]
120242700  RAB7A; ras-related protein Rab-7a [KO:K07897]
120228160  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
120221823  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
120240977  STAM; signal transducing adapter molecule 1 [KO:K04705]
120234803  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
120239202  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
120230155  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
120246513  VPS28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
120239317  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
120245267  VPS37B; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
120246190  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
120248095  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
120229102  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
120234292  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
120248411  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
120228287  CHMP6; charged multivesicular body protein 6 [KO:K12195]
120242794  CHMP4B; charged multivesicular body protein 4b isoform X1 [KO:K12194]
120247038  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
120225014  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
120227095  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
120225449  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
120239486  CHMP7; charged multivesicular body protein 7 [KO:K15053]
120223319  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
120245031  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
120223562  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
120228166  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
120220195  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
120241755  CHMP5; charged multivesicular body protein 5 [KO:K12198]
120224969  LOW QUALITY PROTEIN: IST1 homolog [KO:K19476]
120223645  IST1; IST1 homolog isoform X1 [KO:K19476]
120246258  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
120221764  SPG21; maspardin isoform X1 [KO:K19367]
120223340  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
120221357  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
120246102  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
120240191  SNX32; sorting nexin-32 isoform X1 [KO:K17920]
120248247  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
120248591  SNX6; sorting nexin-6 [KO:K17920]
120228611  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120223392  HRAS; GTPase HRas isoform X1 [KO:K02833]
120237209  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
120241202  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
120246070  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
120229394  RHOA; transforming protein RhoA [KO:K04513]
120249159  transforming protein RhoA-like [KO:K04513]
120226363  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
120221878  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
120221918  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
120222660  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
120236664  folate receptor alpha-like [KO:K13649]
120245128  folate receptor alpha-like [KO:K13649]
120245129  FOLR2; folate receptor beta [KO:K13649]
120245130  folate receptor beta-like [KO:K13649]
120223824  CAV1; caveolin-1 isoform X1 [KO:K06278]
120223825  CAV2; caveolin-2 [KO:K12958]
120231339  CAV3; caveolin-3 [KO:K12959]
120226038  EHD3; EH domain-containing protein 3 [KO:K12476]
120232270  EHD4; EH domain-containing protein 4 [KO:K12477]
120234655  EEA1; early endosome antigen 1 [KO:K12478]
120222031  RAB5A; ras-related protein Rab-5A [KO:K07887]
120219965  RAB5B; ras-related protein Rab-5B [KO:K07888]
120239005  LOW QUALITY PROTEIN: ras-related protein Rab-5C-like [KO:K07889]
120248450  RAB5C; ras-related protein Rab-5C [KO:K07889]
120246893  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
120231305  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
120237825  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
120232478  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
120245684  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
120240132  EHD1; EH domain-containing protein 1 [KO:K12483]
120241271  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
120245876  SNX4; sorting nexin-4 [KO:K17919]
120221594  RAB31; ras-related protein Rab-31 isoform X1 [KO:K07891]
120234864  RAB22A; ras-related protein Rab-22A [KO:K07891]
120235828  RAB10; ras-related protein Rab-10 [KO:K07903]
120239195  RAB8A; ras-related protein Rab-8A [KO:K07901]
120232301  RAB35; ras-related protein Rab-35 [KO:K07876]
120221333  RAB11A; ras-related protein Rab-11A [KO:K07904]
120244869  RAB11B; ras-related protein Rab-11B [KO:K07905]
120238657  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
120235184  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
120248517  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
120230579  ZFYVE27; protrudin isoform X1 [KO:K19368]
120240008  KIF5C; kinesin heavy chain [KO:K10396]
120242748  KIF5B; kinesin-1 heavy chain [KO:K10396]
120248003  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
120241556  RAB11FIP3; rab11 family-interacting protein 3 [KO:K12485]
120245333  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
120247429  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
120224644  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
120240945  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
120230457  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
120242512  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
120234619  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
120233626  cell division control protein 42 homolog [KO:K04393]
120231260  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120240930  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
120247872  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
120245831  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
120239416  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
120232401  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
120240871  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
120231132  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
120230678  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
120231394  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
120242531  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
120245108  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
120224774  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
120228567  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
120234355  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
120229524  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
120230911  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
120248023  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
120234964  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
120234156  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
120228416  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
120234007  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
120239621  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
120231560  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
120245608  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
120234447  IQSEC3; IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
120222961  IQSEC2; IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
120242712  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
120227964  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
120228279  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
120241192  CYTH4; cytohesin-4 [KO:K18441]
120242339  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
120230408  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
120241673  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
120239580  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
120244269  ADP-ribosylation factor 2 [KO:K07937]
120222426  ARF1; ADP-ribosylation factor 1 [KO:K07937]
120223001  ARF3; ADP-ribosylation factor 3 [KO:K07938]
120238620  ARF4; ADP-ribosylation factor 4 [KO:K07939]
120239267  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
hhv04060  Cytokine-cytokine receptor interaction
hhv04070  Phosphatidylinositol signaling system
hhv04130  SNARE interactions in vesicular transport
hhv04142  Lysosome
hhv04350  TGF-beta signaling pathway
KO pathway
ko04144   
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