Entry
Name
Cytokine-cytokine receptor interaction - Hyaena hyaena (striped hyena)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
hhv04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Hyaena hyaena (striped hyena) [GN:
hhv ]
Gene
120231111 growth-regulated protein homolog gamma-like isoform X1 [KO:K05505 ]
120245487 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
120231586 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
120244521 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
120223299 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
120224200 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
120237510 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
120234588 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
120248657 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
120231371 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
120237616 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
120223283 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
120226683 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
120226682 TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X1 [KO:K05479 ]
120231372 tumor necrosis factor ligand superfamily member 13-like [KO:K05475 ]
120228341 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
120243258 TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375 ]
120221741 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
120231992 TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377 ]
120241202 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
120246070 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
120249049 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
120237184 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
120240554 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
120240549 LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
120240562 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066 ]
120247969 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
120244920 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
120239954 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
120241734 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
120239142 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
120232628 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
120245311 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
120241715 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
120229995 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
120224467 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
120221151 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
120224910 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
120221148 LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
120242518 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
120234928 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
120223778 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
120245969 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
120233928 tumor necrosis factor receptor superfamily member 25-like isoform X1 [KO:K04722 ]
120231223 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
120227151 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
120228984 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
120228662 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
120230802 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
120241573 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
120224912 tumor necrosis factor receptor superfamily member 8-like [KO:K05145 ]
120243315 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
120233631 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
120242580 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
120242577 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
120232734 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
120228805 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
120233452 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
120247555 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
120222198 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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