KEGG   PATHWAY: hmh05146
Entry
hmh05146                    Pathway                                
Name
Amoebiasis - Hylobates moloch (silvery gibbon)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
hmh05146  Amoebiasis
hmh05146

Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116483283  IL1B; interleukin-1 beta [KO:K04519]
116483372  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
116483129  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116811162  HSPB1; heat shock protein beta-1 [KO:K04455]
116463881  LOW QUALITY PROTEIN: mucin-2-like [KO:K10955]
116463887  mucin-2-like [KO:K10955]
116814099  COL1A2; collagen alpha-2(I) chain [KO:K06236]
116474649  COL1A1; collagen alpha-1(I) chain [KO:K06236]
116467559  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
116467560  COL4A1; collagen alpha-1(IV) chain isoform X5 [KO:K06237]
116810136  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
116810138  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
116811148  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
116811947  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
116810333  FN1; fibronectin isoform X1 [KO:K05717]
116476913  LAMA2; laminin subunit alpha-2 [KO:K05637]
116468730  LAMA1; laminin subunit alpha-1 [KO:K05637]
116468664  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
116461395  LAMA5; laminin subunit alpha-5 [KO:K06240]
116471121  LAMA4; laminin subunit alpha-4 [KO:K06241]
116810921  LAMB1; laminin subunit beta-1 [KO:K05636]
116473484  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
116457403  LAMB3; laminin subunit beta-3 [KO:K06244]
116809645  LAMB4; laminin subunit beta-4 [KO:K06245]
116457708  LAMC1; laminin subunit gamma-1 [KO:K05635]
116457985  LAMC2; laminin subunit gamma-2 [KO:K06246]
116475776  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
116466067  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
116475178  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
116483096  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
116475175  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
116483095  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
116468938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116461202  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116461370  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
116481969  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6 [KO:K05858] [EC:3.1.4.11]
116483969  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116471147  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116479165  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
116812065  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
116463273  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
116463274  neuroendocrine secretory protein 55 [KO:K04632]
116463360  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
116463361  neuroendocrine secretory protein 55 [KO:K04632]
116468756  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
116812469  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116458418  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
116469844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116478588  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116473751  RAB5A; ras-related protein Rab-5A [KO:K07887]
116480935  RAB5B; ras-related protein Rab-5B [KO:K07888]
116474856  RAB5C; ras-related protein Rab-5C [KO:K07889]
116466799  RAB7A; ras-related protein Rab-7a [KO:K07897]
116457650  RAB7B; ras-related protein Rab-7b [KO:K07898]
116465400  TLR2; toll-like receptor 2 [KO:K10159]
116475593  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
116471599  CD14; monocyte differentiation antigen CD14 [KO:K04391]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116466971  C-X-C motif chemokine 2 isoform X1 [KO:K05505]
116475080  C-X-C motif chemokine 3 [KO:K05505]
116475085  CXCL1; growth-regulated alpha protein [KO:K05505]
116470324  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
116467002  CXCL8; interleukin-8 [KO:K10030]
116460115  TNF; tumor necrosis factor isoform X2 [KO:K03156]
116463392  interleukin-12 subunit alpha [KO:K05406]
116463424  interleukin-12 subunit alpha [KO:K05406]
116471783  IL12B; interleukin-12 subunit beta [KO:K05425]
116467914  CD1A; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1a [KO:K06448]
116469246  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
116469247  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
116469248  CD1C; T-cell surface glycoprotein CD1c [KO:K06448]
116469250  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
116479646  IFNG; interferon gamma [KO:K04687]
116810557  COL3A1; collagen alpha-1(III) chain [KO:K19720]
116813620  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116459793  VCL; vinculin isoform X1 [KO:K05700]
116480733  ACTN4; alpha-actinin-4 isoform X4 [KO:K05699]
116456158  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
116472286  ARG1; arginase-1 isoform X2 [KO:K01476] [EC:3.5.3.1]
116456112  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
116474634  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
116482555  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
116470566  ITGAM; integrin alpha-M [KO:K06461]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116473090  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
116459648  SERPINB6; serpin B6 isoform X1 [KO:K13963]
116459647  SERPINB9; serpin B9 [KO:K13963]
116468488  serpin B3-like [KO:K13963]
116468487  SERPINB3; serpin B3 isoform X2 [KO:K13963]
116468485  SERPINB10; serpin B10 [KO:K13963]
116468058  SERPINB13; serpin B13 isoform X1 [KO:K13963]
116468484  HMSD; serpin-like protein HMSD isoform X1 [KO:K13963]
116484819  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
116457671  IL10; interleukin-10 [KO:K05443]
116480647  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
116457529  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
116456166  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
116457512  C8A; complement component C8 alpha chain [KO:K03997]
116457266  C8B; complement component C8 beta chain [KO:K03998]
116475894  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
116456629  C9; complement component C9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
hmh00330  Arginine and proline metabolism
hmh00590  Arachidonic acid metabolism
hmh04144  Endocytosis
hmh04210  Apoptosis
hmh04510  Focal adhesion
hmh04610  Complement and coagulation cascades
hmh04612  Antigen processing and presentation
hmh04620  Toll-like receptor signaling pathway
hmh04672  Intestinal immune network for IgA production
hmh04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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