KEGG   PATHWAY: hmh04510
Entry
hmh04510                    Pathway                                
Name
Focal adhesion - Hylobates moloch (silvery gibbon)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
hmh04510  Focal adhesion
hmh04510

Other DBs
GO: 0005925
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116456158  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
116456319  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
116456646  MYL5; myosin light chain 5 [KO:K12753]
116457363  JUN; transcription factor Jun [KO:K04448]
116457403  LAMB3; laminin subunit beta-3 [KO:K06244]
116457631  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
116457708  LAMC1; laminin subunit gamma-1 [KO:K05635]
116457885  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
116457897  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116457985  LAMC2; laminin subunit gamma-2 [KO:K06246]
116458283  CRK; adapter molecule crk isoform X1 [KO:K04438]
116458566  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
116458651  PARVG; gamma-parvin isoform X1 [KO:K06275]
116458711  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116458915  CRKL; crk-like protein [KO:K04438]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116459279  PARVB; beta-parvin isoform X1 [KO:K06275]
116459424  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
116459737  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
116459782  TNXB; tenascin-X [KO:K06252]
116459793  VCL; vinculin isoform X1 [KO:K05700]
116459824  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
116460133  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
116460204  [KO:K00889] [EC:2.7.1.68]
116460758  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116460812  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
116460949  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
116461023  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116461211  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
116461395  LAMA5; laminin subunit alpha-5 [KO:K06240]
116461447  SPP1; osteopontin isoform X1 [KO:K06250]
116461711  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
116461734  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
116461858  ITGB1; integrin beta-1 [KO:K05719]
116462068  COL2A1; collagen alpha-1(II) chain [KO:K19719]
116462088  [KO:K06238]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116462272  ITGA2; integrin alpha-2 [KO:K06481]
116462304  ITGA1; integrin alpha-1 [KO:K06480]
116462385  EMP2; epithelial membrane protein 2 [KO:K26256]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116462932  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463464  [KO:K05450]
116463488  [KO:K05450]
116463805  [KO:K13709]
116464630  [KO:K17447]
116465188  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
116466046  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
116466571  HRAS; GTPase HRas isoform X3 [KO:K02833]
116466693  CAV3; caveolin-3 [KO:K12959]
116466754  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116466843  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
116466848  MYLK; myosin light chain kinase, smooth muscle isoform X3 [KO:K00907] [EC:2.7.11.18]
116466895  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116467120  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116467343  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116467558  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116467559  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
116467560  COL4A1; collagen alpha-1(IV) chain isoform X5 [KO:K06237]
116467997  ITGA10; integrin alpha-10 [KO:K06586]
116468493  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
116468664  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
116468684  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116468710  [KO:K12757]
116468711  [KO:K12757]
116468730  LAMA1; laminin subunit alpha-1 [KO:K05637]
116468948  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
116468949  BAD; bcl2-associated agonist of cell death [KO:K02158]
116469079  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116469117  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
116469182  FLNB; filamin-B [KO:K27392]
116469239  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
116469279  [KO:K04513]
116469325  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
116469345  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
116469450  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
116469612  RAP1A; ras-related protein Rap-1A [KO:K04353]
116469686  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116470253  MYL11; myosin regulatory light chain 11 [KO:K12758]
116470814  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
116471050  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
116471062  THBS4; thrombospondin-4 [KO:K04659]
116471121  LAMA4; laminin subunit alpha-4 [KO:K06241]
116471147  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116471637  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
116471711  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116471959  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116472548  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
116472569  VWF; von Willebrand factor [KO:K03900]
116472711  EMP1; epithelial membrane protein 1 [KO:K26255]
116473008  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116473198  TNR; tenascin-R isoform X1 [KO:K06252]
116473202  TNN; tenascin-N [KO:K06252]
116473478  RHOA; transforming protein RhoA [KO:K04513]
116473484  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
116473623  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
116473673  ITGA9; integrin alpha-9 [KO:K06585]
116474495  ITGA8; integrin alpha-8 [KO:K06584]
116474619  VTN; vitronectin [KO:K06251]
116474643  CHAD; chondroadherin [KO:K06248]
116474649  COL1A1; collagen alpha-1(I) chain [KO:K06236]
116474657  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
116474757  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116474918  IBSP; bone sialoprotein 2 [KO:K06253]
116474939  ITGA2B; integrin alpha-IIb [KO:K06476]
116475015  ITGB3; integrin beta-3 [KO:K06493]
116475069  TLN1; talin-1 isoform X1 [KO:K06271]
116475219  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
116475587  TNC; tenascin [KO:K06252]
116475776  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
116475789  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
116475833  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116476502  PARVA; alpha-parvin [KO:K06275]
116476577  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
116476722  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
116476859  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
116476860  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
116476871  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116476913  LAMA2; laminin subunit alpha-2 [KO:K05637]
116477024  [KO:K04659]
116477832  PXN; paxillin isoform X5 [KO:K05760]
116477929  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
116477930  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116478036  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
116478299  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
116478343  VAV1; proto-oncogene vav [KO:K05730]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116478719  COMP; cartilage oligomeric matrix protein [KO:K04659]
116478979  RAP1B; ras-related protein Rap-1b [KO:K07836]
116479049  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
116479165  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
116479588  [KO:K04725] [EC:2.3.2.27]
116479601  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
116479721  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116479999  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116480242  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
116480287  [KO:K04392]
116480512  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116480719  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
116480733  ACTN4; alpha-actinin-4 isoform X4 [KO:K05699]
116480953  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
116480965  ITGA5; integrin alpha-5 [KO:K06484]
116481014  ITGB7; integrin beta-7 [KO:K06590]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481428  TLN2; talin-2 isoform X1 [KO:K06271]
116481469  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
116481493  [KO:K12757]
116481505  THBS1; thrombospondin-1 [KO:K16857]
116481523  SHC4; SHC-transforming protein 4 [KO:K17449]
116481689  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
116481730  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
116481731  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
116482053  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116482110  IGF1R; insulin-like growth factor 1 receptor isoform X4 [KO:K05087] [EC:2.7.10.1]
116482295  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116482335  ITGA11; integrin alpha-11 [KO:K06587]
116482510  [KO:K12757]
116482888  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116483336  ACTG1; actin, cytoplasmic 2 [KO:K05692]
116483764  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
116483790  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
116483969  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116484062  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
116484080  ITGB4; integrin beta-4 [KO:K06525]
116484153  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116484196  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
116484246  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116484470  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116485057  PGF; placenta growth factor isoform X1 [KO:K16859]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116809556  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
116809645  LAMB4; laminin subunit beta-4 [KO:K06245]
116809682  COL6A3; collagen alpha-3(VI) chain isoform X2 [KO:K06238]
116810136  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
116810138  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
116810333  FN1; fibronectin isoform X1 [KO:K05717]
116810565  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
116810585  ITGA4; integrin alpha-4 [KO:K06483]
116810655  ITGA6; integrin alpha-6 isoform X3 [KO:K06485]
116810755  ITGB6; integrin beta-6 [KO:K06589]
116810841  ACTB; actin, cytoplasmic 1 [KO:K05692]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116810921  LAMB1; laminin subunit beta-1 [KO:K05636]
116811148  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
116811530  VEGFD; vascular endothelial growth factor D [KO:K05449]
116811947  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
116811959  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
116812166  FLNA; filamin-A isoform X1 [KO:K04437]
116812436  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116812492  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116813051  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
116813251  ITGB8; integrin beta-8 [KO:K06591]
116813620  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116814099  COL1A2; collagen alpha-2(I) chain [KO:K06236]
116814200  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
116814268  CAV1; caveolin-1 isoform X1 [KO:K06278]
116814269  CAV2; caveolin-2 isoform X1 [KO:K12958]
116814273  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116814428  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116814471  ZYX; zyxin isoform X1 [KO:K06273]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
hmh04010  MAPK signaling pathway
hmh04060  Cytokine-cytokine receptor interaction
hmh04070  Phosphatidylinositol signaling system
hmh04110  Cell cycle
hmh04151  PI3K-Akt signaling pathway
hmh04310  Wnt signaling pathway
hmh04512  ECM-receptor interaction
hmh04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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