KEGG   PATHWAY: mamb00310
Entry
mamb00310                   Pathway                                
Name
Lysine degradation - Megalobrama amblycephala (Wuchang bream)
Class
Metabolism; Amino acid metabolism
Pathway map
mamb00310  Lysine degradation
mamb00310

Module
mamb_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:mamb00310]
Other DBs
GO: 0006554
Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125247135  aass; alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1 [KO:K14157] [EC:1.5.1.8 1.5.1.9]
125255441  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
125265377  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
125246798  dhtkd1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
125268106  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
125247375  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
125266628  gcdhb; glutaryl-CoA dehydrogenase b [KO:K00252] [EC:1.3.8.6]
125274200  gcdha; glutaryl-CoA dehydrogenase a [KO:K00252] [EC:1.3.8.6]
125278517  hadhaa; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a [KO:K07515] [EC:4.2.1.17 1.1.1.211]
125269353  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
125270062  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
125276891  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
125271929  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
125262266  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
125278072  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
125254632  hykk.2; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
125249736  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
125248207  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
125276769  camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
125249738  kmt2a; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
125259813  kmt2d; histone-lysine N-methyltransferase 2D isoform X1 [KO:K09187] [EC:2.1.1.354]
125252002  kmt2cb; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
125257560  kmt2ca; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
125248738  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2B-like [KO:K14959] [EC:2.1.1.354]
125275959  kmt2ba; histone-lysine N-methyltransferase 2B isoform X1 [KO:K14959] [EC:2.1.1.354]
125245495  kmt2e; inactive histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
125262333  setd1ba; histone-lysine N-methyltransferase SETD1B-A isoform X1 [KO:K11422] [EC:2.1.1.354]
125277583  setd1a; histone-lysine N-methyltransferase SETD1A isoform X1 [KO:K11422] [EC:2.1.1.354]
125280089  setd1bb; histone-lysine N-methyltransferase SETD1B-A [KO:K11422] [EC:2.1.1.354]
125258654  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
125255153  prdm9; histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
125244159  histone-lysine N-methyltransferase ASH1L-like isoform X1 [KO:K06101] [EC:2.1.1.354]
125275540  ash1l; histone-lysine N-methyltransferase ASH1L [KO:K06101] [EC:2.1.1.354]
125277722  smyd2b; N-lysine methyltransferase SMYD2-B isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
125279802  smyd1b; histone-lysine N-methyltransferase SMYD1b isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
125267856  smyd1a; histone-lysine N-methyltransferase SMYD1a [KO:K11426] [EC:2.1.1.354 2.1.1.357]
125268597  smyd3; histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
125269080  smyd2a; N-lysine methyltransferase SMYD2-A [KO:K11426] [EC:2.1.1.354 2.1.1.357]
125279861  suv39h1b; histone-lysine N-methyltransferase SUV39H1b isoform X1 [KO:K11419] [EC:2.1.1.355]
125280489  suv39h1a; histone-lysine N-methyltransferase SUV39H1-A [KO:K11419] [EC:2.1.1.355]
125252857  ehmt1b; histone-lysine N-methyltransferase EHMT1 isoform X1 [KO:K11420] [EC:2.1.1.355]
125266726  ehmt1a; histone-lysine N-methyltransferase EHMT1a isoform X1 [KO:K11420] [EC:2.1.1.355]
125275908  ehmt2; histone-lysine N-methyltransferase EHMT2 isoform X1 [KO:K11420] [EC:2.1.1.355]
125243644  setdb1b; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SETDB1-B [KO:K11421] [EC:2.1.1.366]
125275542  setdb1a; histone-lysine N-methyltransferase SETDB1-A isoform X1 [KO:K11421] [EC:2.1.1.366]
125273173  setdb2; histone-lysine N-methyltransferase SETDB2 [KO:K18494] [EC:2.1.1.355]
125279790  prdm2a; PR domain zinc finger protein 2 isoform X1 [KO:K11432] [EC:2.1.1.355]
125256260  prdm2b; PR domain zinc finger protein 2 isoform X1 [KO:K11432] [EC:2.1.1.355]
125271852  ezh1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
125258300  ezh2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
125257094  setmar; histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
125258751  nsd1a; histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1 [KO:K15588] [EC:2.1.1.357]
125253369  nsd1b; histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1 [KO:K15588] [EC:2.1.1.357]
125276566  nsd2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
125259226  nsd3; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD3 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
125243135  setd2; histone-lysine N-methyltransferase SETD2 [KO:K11423] [EC:2.1.1.359]
125263799  dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
125262448  kmt5aa; N-lysine methyltransferase KMT5A-A [KO:K11428] [EC:2.1.1.361]
125267634  kmt5ab; lysine methyltransferase 5Ab [KO:K11428] [EC:2.1.1.361]
125280692  prdm6; putative histone-lysine N-methyltransferase PRDM6 isoform X1 [KO:K20795] [EC:2.1.1.361]
125254463  kmt5b; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase KMT5B [KO:K11429] [EC:2.1.1.362]
125248870  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
125280292  prdm16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
125253036  tmlhe; trimethyllysine dioxygenase, mitochondrial [KO:K00474] [EC:1.14.11.8]
125252141  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
125248925  aldh3a1; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
125248926  aldh3a2a; aldehyde dehydrogenase family 3 member A2a [KO:K00128] [EC:1.2.1.3]
125267625  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
125276908  aldh16a1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
125279352  aldh9a1a.1; LOW QUALITY PROTEIN: 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
125250605  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
125264800  bbox1; gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
125280283  plod1a; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [KO:K00473] [EC:1.14.11.4]
125257958  plod2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1 [KO:K13645] [EC:1.14.11.4]
125260123  plod3; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
125271017  colgalt1b; procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
125280236  colgalt2b; procollagen galactosyltransferase 2 isoform X1 [KO:K11703] [EC:2.4.1.50]
125267077  colgalt1a; procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
125251523  colgalt2a; procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
125257684  cercam; probable inactive glycosyltransferase 25 family member 3 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
mamb00020  Citrate cycle (TCA cycle)
mamb00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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