KEGG   PATHWAY: mamb04110
Entry
mamb04110                   Pathway                                
Name
Cell cycle - Megalobrama amblycephala (Wuchang bream)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
mamb04110  Cell cycle
mamb04110

Other DBs
GO: 0000278
Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125265759  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
125244649  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
125246743  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
125276432  ccndx; cyclin Dx [KO:K10151]
125263038  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
125256866  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
125272351  cdk21; cyclin-dependent kinase 4 [KO:K02091] [EC:2.7.11.22]
125274970  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125253471  rb1; retinoblastoma-associated protein [KO:K06618]
125273583  rbl1; retinoblastoma-like protein 1 [KO:K04681]
125246749  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
125267851  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
125274787  hdac1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
125260481  e2f1; transcription factor E2F1 [KO:K17454]
125269140  e2f2; transcription factor E2F2 [KO:K09389]
125274781  e2f3; transcription factor E2F3 [KO:K06620]
125246716  e2f4; LOW QUALITY PROTEIN: transcription factor E2F4 [KO:K04682]
125250582  e2f5; transcription factor E2F5 [KO:K04682]
125270167  tfdp1a; transcription factor Dp-1a [KO:K04683]
125273012  tfdp1b; transcription factor Dp-1b [KO:K04683]
125248500  tfdp2; transcription factor Dp-2 isoform X1 [KO:K09392]
125269959  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125271949  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
125252540  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
125249338  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
125242838  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
125275660  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
125268277  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
125258281  smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
125264790  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
125254113  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
125262552  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
125243586  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
125266930  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
125275164  smad10a; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
125258151  myca; transcriptional regulator Myc-A [KO:K04377]
125251860  mycb; transcriptional regulator Myc-B [KO:K04377]
125260137  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
125272442  cdkn2a/b; cyclin-dependent kinase inhibitor 2A [KO:K04685]
125279238  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
125274054  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
125244706  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
125247478  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
125265144  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
125247090  cdkn1cb; cyclin-dependent kinase inhibitor 1C [KO:K09993]
125263043  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
125244770  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
125244042  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
125265166  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
125256455  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125253090  skp1; S-phase kinase-associated protein 1 [KO:K03094]
125258299  cul1b; cullin-1b [KO:K03347]
125250170  cul1a; cullin-1a isoform X1 [KO:K03347]
125273687  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
125253496  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
125262743  ccna1; cyclin-A1 [KO:K06627]
125259039  ccna2; cyclin-A2 [KO:K06627]
125256489  cdc6; LOW QUALITY PROTEIN: cell division control protein 6 homolog [KO:K02213]
125265843  cdt1; DNA replication factor Cdt1 isoform X1 [KO:K10727]
125274005  orc1; origin recognition complex subunit 1 [KO:K02603]
125256391  orc2; origin recognition complex subunit 2 [KO:K02604]
125268404  orc3; LOW QUALITY PROTEIN: origin recognition complex subunit 3 [KO:K02605]
125274064  orc4; origin recognition complex subunit 4 [KO:K02606]
125244886  orc5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
125264924  orc6; origin recognition complex subunit 6 [KO:K02608]
125263370  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
125278224  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
125279120  mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like isoform X1 [KO:K02541] [EC:5.6.2.3]
125258622  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
125248655  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
125274326  mcm6; LOW QUALITY PROTEIN: DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
125250169  mcm6l; MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
125267410  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
125279523  cdc45; cell division control protein 45 homolog [KO:K06628]
125246913  ticrr; LOW QUALITY PROTEIN: treslin [KO:K26117]
125243157  mdm2-binding protein [KO:K26116]
125250084  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
125265712  dbf4b; uncharacterized protein dbf4b [KO:K06629]
125243930  dbf4; protein DBF4 homolog A [KO:K06629]
125268849  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
125254637  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
125267878  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
125264722  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
125264486  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
125276581  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
125277830  ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a [KO:K16197]
125243195  ywhabl; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like [KO:K16197]
125279455  ywhabb; 14-3-3 protein beta/alpha-B [KO:K16197]
125273594  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
125275185  ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
125269071  ywhaqb; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b [KO:K16197]
125265200  ywhae2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2 [KO:K06630]
125248370  ywhae1; LOW QUALITY PROTEIN: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630]
125266298  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
125248810  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
125256773  ywhah; 14-3-3 protein eta [KO:K16198]
125272726  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
125254695  wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
125254837  wee1; wee1-like protein kinase isoform X1 [KO:K06632] [EC:2.7.11.1]
125251695  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
125267471  ccnh; cyclin-H [KO:K06634]
125267528  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
125276431  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
125268015  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
125272511  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
125278024  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
125280083  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
125268418  anaphase-promoting complex subunit 5-like [KO:K03352]
125270163  cdc16; cell division cycle protein 16 homolog [KO:K03353]
125280729  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
125252273  LOW QUALITY PROTEIN: cell division cycle protein 23 homolog [KO:K03355]
125253210  cell division cycle protein 23 homolog [KO:K03355]
125260765  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 10-like [KO:K03357]
125272937  anapc11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
125267926  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
125252774  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
125248112  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
125255278  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
125251665  cdc20; cell division cycle protein 20 homolog [KO:K03363]
125259275  pttg1; securin [KO:K06635]
125273720  espl1; LOW QUALITY PROTEIN: separin [KO:K02365] [EC:3.4.22.49]
125279594  smc1al; structural maintenance of chromosomes 1A, like [KO:K06636]
125247549  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
125260674  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
125253501  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
125243460  rad21a; double-strand-break repair protein rad21 homolog A [KO:K06670]
125280329  rad21l1; double-strand-break repair protein rad21-like protein 1 [KO:K06670]
125275094  rad21b; RAD21 cohesin complex component b isoform X1 [KO:K06670]
125270147  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
125258530  stag1b; cohesin subunit SA-1 isoform X1 [KO:K06671]
125258744  stag2b; cohesin subunit SA-2 isoform X1 [KO:K06671]
125266593  stag2a; cohesin subunit SA-2a isoform X1 [KO:K06671]
125250005  stag1a; cohesin subunit SA-1a isoform X1 [KO:K06671]
125259127  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
125266576  transcriptional regulator ATRX-like [KO:K10779]
125253869  ddx11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
125267245  nipbla; nipped-B-like protein A [KO:K06672]
125261336  nipblb; LOW QUALITY PROTEIN: nipped-B-like protein B [KO:K06672]
125250643  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
125265074  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
125258352  esco1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
125278376  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
125272664  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
125248353  pds5b; LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
125255870  waplb; wings apart-like protein homolog [KO:K25163]
125268818  wapla; wings apart-like protein homolog [KO:K25163]
125267759  cdca5; sororin [KO:K17390]
125266895  aurkb; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
125274667  sgo1; shugoshin 1 isoform X1 [KO:K11580]
125258755  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
125253086  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125256296  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125248530  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
125267946  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
125277759  ppp2r5ea; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
125278606  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
125278981  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125264571  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
125269203  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125277321  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
125255750  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
125272786  knl1; uncharacterized protein knl1 isoform X1 [KO:K11542]
125243638  ttk; dual specificity protein kinase Ttk isoform X1 [KO:K08866] [EC:2.7.12.1]
125272741  mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
125265888  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
125269269  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
125255232  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
125278877  bub1; LOW QUALITY PROTEIN: mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
125243506  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
125277133  MAD2L1-binding protein [KO:K26093]
125280018  fzr1a; fizzy/cell division cycle 20 related 1a [KO:K03364]
125250092  fizzy-related protein homolog isoform X1 [KO:K03364]
125251774  fzr1b; fizzy-related protein homolog [KO:K03364]
125276429  fbxo5; F-box only protein 5 [KO:K10292]
125279319  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
125250235  cdc14aa; cell division cycle 14Aa isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
125251317  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
125262381  crebbpb; LOW QUALITY PROTEIN: CREB binding protein b [KO:K04498] [EC:2.3.1.48]
125263710  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125273590  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125255280  ep300a; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
125256000  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
125277589  LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit-like [KO:K06642] [EC:2.7.11.1]
125264940  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
125250462  atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
125248362  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
125244871  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
125265599  cellular tumor antigen p53-like [KO:K04451]
125266618  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
125279667  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
125253299  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
125273851  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
125251021  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
125256835  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
125251371  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
125253301  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
125262310  pcna; proliferating cell nuclear antigen [KO:K04802]
125253492  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
125267298  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
mamb03030  DNA replication
mamb04010  MAPK signaling pathway
mamb04120  Ubiquitin mediated proteolysis
mamb04210  Apoptosis
KO pathway
ko04110   
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