KEGG   PATHWAY: mbez04218
Entry
mbez04218                   Pathway                                
Name
Cellular senescence - Moschus berezovskii (Chinese forest musk deer)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
mbez04218  Cellular senescence
mbez04218

Other DBs
GO: 0090398
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129546785  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
129551685  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
129562431  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
129556858  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
129548192  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
129549831  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
129562707  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
129557537  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
129536501  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
129552220  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
129548664  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129536390  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
129543836  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
129556262  RB1; retinoblastoma-associated protein [KO:K06618]
129563231  RBL1; retinoblastoma-like protein 1 [KO:K04681]
129547109  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
129562499  E2F1; transcription factor E2F1 [KO:K17454]
129538357  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
129543202  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
129559972  LOW QUALITY PROTEIN: transcription factor E2F3-like [KO:K06620]
129559907  E2F5; transcription factor E2F5 [KO:K04682]
129547015  E2F4; transcription factor E2F4 [KO:K04682]
129551508  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129547146  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129559156  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129553207  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
129540801  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129556309  FOXO1; forkhead box protein O1 [KO:K07201]
129561025  FOXO3; forkhead box protein O3 [KO:K09408]
129543530  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
129536910  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
129551017  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
129562125  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
129560436  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
129546919  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
129543112  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543113  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
129543114  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543175  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543498  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
129558890  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
129537164  KRAS; GTPase KRas isoform X1 [KO:K07827]
129541808  NRAS; GTPase NRas [KO:K07828]
129546539  RRAS; ras-related protein R-Ras [KO:K07829]
129554492  RRAS2; ras-related protein R-Ras2 [KO:K07830]
129547251  MRAS; ras-related protein M-Ras [KO:K07831]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129539141  TSC1; hamartin isoform X1 [KO:K07206]
129545260  TSC2; tuberin isoform X1 [KO:K07207]
129550533  GTP-binding protein Rheb-like [KO:K07208]
129552798  RHEB; GTP-binding protein Rheb [KO:K07208]
129551531  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
129555578  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129555789  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
129556602  CCNA1; cyclin-A1 [KO:K06627]
129561794  CCNA2; cyclin-A2 [KO:K06627]
129563841  MYBL2; myb-related protein B [KO:K21769]
129551630  LIN9; protein lin-9 homolog [KO:K21773]
129546124  LIN37; protein lin-37 homolog isoform X1 [KO:K21774]
129562425  LIN52; protein lin-52 homolog isoform X1 [KO:K21775]
129540410  LOW QUALITY PROTEIN: protein lin-54 homolog [KO:K21776]
129562140  LIN54; protein lin-54 homolog isoform X1 [KO:K21776]
129563192  histone-binding protein RBBP4-like [KO:K10752]
129549768  histone-binding protein RBBP4-like [KO:K10752]
129538249  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
129552335  histone-binding protein RBBP4-like [KO:K10752]
129537023  FOXM1; forkhead box protein M1 isoform X1 [KO:K09406]
129560340  MYC; myc proto-oncogene protein [KO:K04377]
129557536  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
129535751  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129543141  TP53; cellular tumor antigen p53 [KO:K04451]
129551738  RASSF5; ras association domain-containing protein 5 [KO:K08015]
129553143  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
129555427  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
129552697  HIPK2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
129540598  HIPK1; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
129546811  HIPK4; LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
129554731  HIPK3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
129542802  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129537845  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129539892  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129548700  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129558523  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129548939  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
129544242  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
129544772  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
129537071  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
129537073  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129543604  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129543888  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129545108  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
129558359  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
129541549  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
129555810  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
129551652  G2/mitotic-specific cyclin-B1-like [KO:K05868]
129553034  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
129553550  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
129563160  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
129557795  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3-like [KO:K21771]
129564503  CCNB3; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3 [KO:K21771]
129554227  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
129558700  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
129560447  NBN; nibrin isoform X1 [KO:K10867]
129554297  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
129542403  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
129548698  RAD9A; cell cycle checkpoint control protein RAD9A isoform X1 [KO:K10994] [EC:3.1.11.2]
129542732  RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
129553328  RAD1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
129552543  HUS1; checkpoint protein HUS1 isoform X1 [KO:K10903]
129546928  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
129548956  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
129547792  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
129552589  sequestosome-1-like [KO:K14381]
129559451  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
129557377  GATA4; transcription factor GATA-4 [KO:K09183]
129560711  TRAF3IP2; E3 ubiquitin ligase TRAF3IP2 isoform X1 [KO:K21124]
129562101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129548767  RELA; transcription factor p65 [KO:K04735]
129539790  IL1A; interleukin-1 alpha [KO:K04383]
129562064  CXCL8; interleukin-8 [KO:K10030]
129552547  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
129545661  SERPINE1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
129549398  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
129551733  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
129539043  ZFP36L2; mRNA decay activator protein ZFP36L2 [KO:K18753]
129547932  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129542407  TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
129563605  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
129548783  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
129551654  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
129562982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
129563274  calmodulin-1-like [KO:K02183]
129563997  calmodulin-like [KO:K02183]
129564337  calmodulin-1-like [KO:K02183]
129550549  calmodulin-1-like [KO:K02183]
129550970  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
129551800  calmodulin-1-like [KO:K02183]
129539293  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129546635  CALM3; calmodulin-3 [KO:K02183]
129554732  uncharacterized protein LOC129554732 [KO:K02183]
129555444  calmodulin-like [KO:K02183]
129562351  calmodulin-1-like [KO:K02183]
129562550  CALM1; calmodulin-1 isoform X1 [KO:K02183]
129556888  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129562133  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129555711  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129539040  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129549652  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129535111  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
129546977  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
129562963  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
129548039  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
129536224  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
129543844  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
129542617  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
129549309  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129564629  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129535024  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
129557628  peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
129542227  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
129558217  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129555687  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129549434  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
129560157  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129562882  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129555725  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
mbez04020  Calcium signaling pathway
mbez04068  FoxO signaling pathway
mbez04110  Cell cycle
mbez04115  p53 signaling pathway
mbez04150  mTOR signaling pathway
KO pathway
ko04218   
LinkDB

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