Entry Name mTOR signaling pathway - Mastomys coucha (southern multimammate mouse)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Organism Mastomys coucha (southern multimammate mouse) [GN:
mcoc ]
Gene 116070319 Slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780 ]
116083091 Slc38a9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995 ]
116099943 Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
116069414 Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
116080803 Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148 ]
116068633 Lamtor4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399 ]
116069573 Castor1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080 ]
116068504 Castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081 ]
116081595 Deptor; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
116077533 Telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137 ]
116068398 Clip1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421 ]
116068552 Grb10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064 ]
116069093 Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
116088713 Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
116081759 Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
116076742 Strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
116088473 Stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532 ]
116103296 Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068 ]
116099693 Lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
116097159 Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
116085718 Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
116079062 Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
116099614 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
116096465 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
116083721 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
116069491 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
116095058 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116097037 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116073929 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116090042 Mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410 ]
116083691 Rictor; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related KO pathway LinkDB All DBs
