KEGG   PATHWAY: mcoc04151
Entry
mcoc04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Mastomys coucha (southern multimammate mouse)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcoc04151  PI3K-Akt signaling pathway
mcoc04151

Other DBs
GO: 0043491
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116099176  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
116104470  Ereg; proepiregulin [KO:K09784]
116070647  Areg; amphiregulin [KO:K09782]
116087087  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116095116  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116098343  Fgf6; fibroblast growth factor 6 [KO:K04358]
116100989  Fgf3; fibroblast growth factor 3 [KO:K04358]
116100990  Fgf4; fibroblast growth factor 4 [KO:K04358]
116101280  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116083356  Fgf10; fibroblast growth factor 10 [KO:K04358]
116093940  Fgf16; fibroblast growth factor 16 [KO:K04358]
116084437  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116084719  Fgf9; fibroblast growth factor 9 [KO:K04358]
116076064  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
116078435  Fgf18; fibroblast growth factor 18 [KO:K04358]
116071359  Fgf20; fibroblast growth factor 20 [KO:K04358]
116090856  Fgf7; fibroblast growth factor 7 [KO:K04358]
116100991  Fgf19; fibroblast growth factor 19 [KO:K22603]
116100498  Fgf21; fibroblast growth factor 21 [KO:K22429]
116098344  Fgf23; fibroblast growth factor 23 [KO:K22428]
116093520  Ngf; beta-nerve growth factor isoform X1 [KO:K02582]
116090620  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116099618  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
116102198  Ntf4; neurotrophin-4 [KO:K12457]
116101481  insulin-1 [KO:K04526]
116076407  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
116103249  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
116068639  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116076069  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116093026  Pdgfc; platelet-derived growth factor C [KO:K05450]
116072446  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116093601  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
116076467  Kitlg; kit ligand isoform X1 [KO:K05461]
116102173  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116074720  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
116103472  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
116079820  Pgf; placenta growth factor [KO:K16859]
116069284  Vegfc; vascular endothelial growth factor C [KO:K05449]
116090438  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
116097489  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116082804  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
116068986  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
116091151  Angpt4; angiopoietin-4 [KO:K05467]
116093165  Efna1; ephrin-A1 isoform X1 [KO:K05462]
116093166  Efna3; ephrin-A3 isoform X1 [KO:K05462]
116093175  Efna4; ephrin-A4 [KO:K05462]
116076345  Efna2; ephrin-A2 [KO:K05462]
116088835  Efna5; ephrin-A5 isoform X1 [KO:K05462]
116083531  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
116074689  Nrtn; neurturin [KO:K25414]
116095512  Artn; artemin isoform X1 [KO:K25415]
116075510  Pspn; persephin [KO:K25416]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116077605  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116076169  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
116088530  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
116069056  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116103077  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116069961  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116082061  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116078356  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116094433  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
116093096  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116082168  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
116068825  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
116102373  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116071260  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116087228  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116071281  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116068778  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
116068780  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116078943  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116071284  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116098601  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116096241  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116096958  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116099474  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
116076719  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
116080813  Sos1; son of sevenless homolog 1 [KO:K03099]
116080934  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116088647  Irs1; insulin receptor substrate 1 [KO:K16172]
116093042  Tlr2; toll-like receptor 2 [KO:K10159]
116096145  Tlr4; toll-like receptor 4 [KO:K10160]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116081405  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
116102950  Cd19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
116103827  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
116077584  somatotropin [KO:K05438]
116082128  prolactin-2A1 [KO:K05439]
116082207  prolactin-5A1 [KO:K05439]
116082394  prolactin-like [KO:K05439]
116082402  prolactin-5A1-like [KO:K05439]
116082510  prolactin-6A1 [KO:K05439]
116081753  prolactin-5A1-like [KO:K05439]
116081775  prolactin-2C2-like isoform X1 [KO:K05439]
116081833  Prl; prolactin isoform X1 [KO:K05439]
116069310  Osm; oncostatin-M isoform X1 [KO:K05418]
116094798  Il2; interleukin-2 [KO:K05429]
116078664  interleukin-3-like [KO:K04736]
116097436  Il6; interleukin-6 [KO:K05405]
116078788  Il4; interleukin-4 [KO:K05430]
116094928  Il7; interleukin-7 isoform X1 [KO:K05431]
116095401  interferon alpha-7-like [KO:K05414]
116095403  interferon alpha-1-like [KO:K05414]
116095406  interferon alpha-9-like [KO:K05414]
116095408  interferon alpha-12-like [KO:K05414]
116095410  interferon alpha-1 [KO:K05414]
116095416  interferon alpha-1-like [KO:K05414]
116095417  interferon alpha-4-like [KO:K05414]
116095418  interferon alpha-12 [KO:K05414]
116095419  interferon alpha-7-like [KO:K05414]
116095420  interferon alpha-12-like [KO:K05414]
116095421  interferon alpha-7-like [KO:K05414]
116096218  interferon alpha-11 [KO:K05414]
116095400  Ifnb1; interferon beta [KO:K05415]
116070961  Epo; erythropoietin isoform X1 [KO:K05437]
116077970  Csf3; granulocyte colony-stimulating factor [KO:K05423]
116083333  Ghr; growth hormone receptor isoform X1 [KO:K05080]
116083209  Prlr; prolactin receptor [KO:K05081]
116083573  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
116082367  Il2ra; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
116075473  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
116087170  Il2rg; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
116078335  interleukin-3 receptor subunit alpha-like isoform X1 [KO:K04737]
116093191  Il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
116102932  Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
116083490  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
116086128  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
116086124  Ifnar2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116073027  Epor; erythropoietin receptor isoform X1 [KO:K05079]
116096625  Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
116096295  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
116103711  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
116069528  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
116098542  Col1a2; collagen alpha-2(I) chain [KO:K06236]
116078726  Col1a1; collagen alpha-1(I) chain [KO:K06236]
116078858  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
116096167  Col4a5; collagen alpha-5(IV) chain [KO:K06237]
116068903  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
116068904  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
116088649  Col4a4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
116088650  Col4a3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
116089039  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
116073903  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
116074557  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
116074943  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
116088753  Col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
116072199  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
116073354  collagen alpha-4(VI) chain [KO:K06238]
116096559  Col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
116089097  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
116091849  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
116097932  Lama2; laminin subunit alpha-2 [KO:K05637]
116088869  Lama1; laminin subunit alpha-1 [KO:K05637]
116086852  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
116091524  Lama5; laminin subunit alpha-5 [KO:K06240]
116075456  Lama4; laminin subunit alpha-4 [KO:K06241]
116080788  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
116072107  Lamb2; laminin subunit beta-2 [KO:K06243]
116069150  Lamb3; laminin subunit beta-3 [KO:K06244]
116101239  Lamc1; laminin subunit gamma-1 [KO:K05635]
116101229  Lamc2; laminin subunit gamma-2 [KO:K06246]
116089980  Lamc3; laminin subunit gamma-3 [KO:K06247]
116077683  Chad; chondroadherin [KO:K06248]
116097519  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
116090684  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
116083530  Thbs4; thrombospondin-4 [KO:K04659]
116093161  Thbs3; thrombospondin-3 [KO:K04659]
116077949  Thbs2; thrombospondin-2 [KO:K04659]
116069462  Comp; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
116088545  Fn1; fibronectin isoform X1 [KO:K05717]
116070754  Spp1; osteopontin [KO:K06250]
116077245  Vtn; vitronectin [KO:K06251]
116102168  Tnr; tenascin-R isoform X1 [KO:K06252]
116096134  Tnc; tenascin isoform X1 [KO:K06252]
116074684  Tnxb; tenascin-X isoform X1 [KO:K06252]
116070755  Tnn; tenascin-N isoform X1 [KO:K06252]
116099616  Vwf; von Willebrand factor isoform X1 [KO:K03900]
116070752  Ibsp; bone sialoprotein 2 [KO:K06253]
116083732  Itga1; integrin alpha-1 isoform X1 [KO:K06480]
116083244  Itga2; integrin alpha-2 [KO:K06481]
116078214  Itga2b; integrin alpha-IIb [KO:K06476]
116078986  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
116090371  Itga4; integrin alpha-4 [KO:K06483]
116080860  Itga5; integrin alpha-5 [KO:K06484]
116090300  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
116075887  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
116089710  Itga8; integrin alpha-8 [KO:K06584]
116073780  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
116093463  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
116073011  Itga11; integrin alpha-11 isoform X1 [KO:K06587]
116090387  Itgav; integrin alpha-V isoform X1 [KO:K06487]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116076922  Itgb3; integrin beta-3 [KO:K06493]
116077406  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
116085844  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
116090215  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
116080371  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
116080974  Itgb8; integrin beta-8 [KO:K06591]
116073569  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116083372  F2r; proteinase-activated receptor 1 [KO:K03914]
116103504  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
116098726  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
116096072  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
116069430  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
116093916  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
116088074  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
116099597  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
116085076  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
116097142  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
116068597  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
116099581  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
116095064  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
116073026  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
116085348  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
116103521  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116082206  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116093923  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116076327  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116101712  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
116096080  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116098540  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
116099017  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116069754  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
116078416  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
116097985  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116078231  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
116079916  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
116077708  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
116077916  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
116078189  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
116076582  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
116096329  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
116083203  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
116074523  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
116089904  Tsc1; hamartin isoform X1 [KO:K07206]
116078562  Tsc2; tuberin isoform X1 [KO:K07207]
116097567  Rheb; GTP-binding protein Rheb [KO:K07208]
116078499  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
116097015  Mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116077504  Rptor; regulatory-associated protein of mTOR [KO:K07204]
116069093  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
116093849  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
116088713  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
116081759  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
116103319  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
116079205  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
116081007  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
116096209  Rps6; 40S ribosomal protein S6 [KO:K02991]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116069688  Pkn1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
116093881  Pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
116089931  Pkn3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
116097831  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
116091335  Sgk2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
116088156  serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116099295  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
116097498  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
116103746  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116093361  Them4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
116104772  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116077586  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116079262  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
116073310  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
116103147  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
116085366  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
116087108  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
116070475  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
116081027  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
116073268  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
116103440  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
116075523  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
116068891  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
116080027  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
116080458  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
116074367  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
116081114  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
116075702  Hsp90b1; endoplasmin [KO:K09487]
116072154  Cdc37; hsp90 co-chaperone Cdc37 isoform X1 [KO:K09554]
116093209  Crtc2; CREB-regulated transcription coactivator 2 [KO:K16333]
116097182  Phlpp1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
116070157  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
116080558  Tcl1a; T-cell leukemia/lymphoma protein 1A [KO:K10167]
116081107  Tcl1b; T-cell leukemia/lymphoma protein 1B [KO:K16836]
116086500  Mtcp1; protein p13 MTCP-1 [KO:K16837]
116097543  Nos3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
116078743  Brca1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
116085894  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116102200  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
116098429  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
116092572  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
116084755  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
116076828  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
116077838  G6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
116092006  G6pc2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
116082253  Myc; myc proto-oncogene protein [KO:K04377]
116103285  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
116075178  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116099702  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
116076163  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
116075684  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116097440  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
116099629  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
116075067  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
116102054  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
116088079  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116075286  Foxo3; forkhead box protein O3 [KO:K09408]
116069845  Rbl2; retinoblastoma-like protein 2 [KO:K16332]
116070785  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116090896  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
116068539  14-3-3 protein theta-like [KO:K16197]
116079782  Ywhaq; 14-3-3 protein theta [KO:K16197]
116091353  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
116081762  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
116078815  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
116068554  Ywhag; 14-3-3 protein gamma [KO:K16198]
116069796  Ywhah; 14-3-3 protein eta [KO:K16198]
116103467  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116091179  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
116097315  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
116096967  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
116088513  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
116091666  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
116076129  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116095903  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
116098735  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
116093212  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
116076210  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
116090490  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
116098936  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
116075007  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
116093420  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
116089888  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116080043  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
116086280  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116103881  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116069014  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116103403  Rela; transcription factor p65 isoform X1 [KO:K04735]
116093825  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116097822  Myb; transcriptional activator Myb isoform X1 [KO:K09420]
116075923  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
116077116  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mcoc00010  Glycolysis / Gluconeogenesis
mcoc04010  MAPK signaling pathway
mcoc04012  ErbB signaling pathway
mcoc04062  Chemokine signaling pathway
mcoc04064  NF-kappa B signaling pathway
mcoc04068  FoxO signaling pathway
mcoc04110  Cell cycle
mcoc04115  p53 signaling pathway
mcoc04150  mTOR signaling pathway
mcoc04210  Apoptosis
mcoc04370  VEGF signaling pathway
mcoc04510  Focal adhesion
mcoc04620  Toll-like receptor signaling pathway
mcoc04630  JAK-STAT signaling pathway
mcoc04662  B cell receptor signaling pathway
mcoc04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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