Entry
Name
Autophagy - animal - Mastomys coucha (southern multimammate mouse)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mastomys coucha (southern multimammate mouse) [GN:
mcoc ]
Gene
116089083 Irs4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446 ]
116095058 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116097037 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116073929 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116096465 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
116083721 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
116069491 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
116103150 Bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464 ]
116081595 Deptor; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
116077586 Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
116088140 Rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589 ]
116081190 Atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906 ]
116068694 Wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908 ]
116079011 Wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908 ]
116102776 Wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991 ]
116077256 Wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991 ]
116092869 Supt20h; transcription factor SPT20 homolog isoform X1 [KO:K21245 ]
116090219 Tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650 ]
116103467 Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158 ]
116084614 Atg14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889 ]
116090484 Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985 ]
116091232 Tp53inp2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247 ]
116102614 Uvrag; UV radiation resistance-associated gene protein isoform X1 [KO:K21249 ]
116086270 Rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein [KO:K19330 ]
116076830 Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852 ] [EC:2.7.11.1 3.1.26.-]
116099362 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
116080060 Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
116080649 Zfyve1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603 ]
116099420 Atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337 ]
116083837 Atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888 ]
116085951 Atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343 ]
116088466 Cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724 ]
116099677 Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
116077104 Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341 ]
116070214 Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
116070311 Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
116091231 Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
116096279 Atg4c; cysteine protease ATG4C isoform X1 [KO:K08342 ] [EC:3.4.22.-]
116073906 Atg4d; cysteine protease ATG4D isoform X1 [KO:K08342 ] [EC:3.4.22.-]
116088808 Atg4b; cysteine protease ATG4B isoform X1 [KO:K08342 ] [EC:3.4.22.-]
116089020 Atg4a; cysteine protease ATG4A isoform X1 [KO:K08342 ] [EC:3.4.22.-]
116077340 Calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348 ]
116067978 Wdfy3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262 ]
116087383 Epg5; ectopic P granules protein 5 homolog isoform X1 [KO:K23883 ]
116076679 Plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
116072784 Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179 ]
116090929 Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
116090719 Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
116068397 Vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
116082714 Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
116090289 Gorasp2; Golgi reassembly-stacking protein 2 isoform X1 [KO:K26797 ]
116073926 Gorasp1; Golgi reassembly-stacking protein 1 isoform X1 [KO:K26797 ]
116068931 Lamp1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528 ]
116078351 Lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
Compound
C00350 Phosphatidylethanolamine
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Meijer AJ, Codogno P.
Title
Regulation and role of autophagy in mammalian cells.
Journal
Reference
Authors
Deretic V.
Title
Autophagy in innate and adaptive immunity.
Journal
Reference
Authors
Levine B, Yuan J.
Title
Autophagy in cell death: an innocent convict?
Journal
Reference
Authors
Tanida I, Ueno T, Kominami E.
Title
LC3 conjugation system in mammalian autophagy.
Journal
Reference
Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
Title
Autophagy in metazoans: cell survival in the land of plenty.
Journal
Reference
Authors
Reggiori F, Klionsky DJ.
Title
Autophagosomes: biogenesis from scratch?
Journal
Reference
Authors
Klionsky DJ, Emr SD.
Title
Autophagy as a regulated pathway of cellular degradation.
Journal
Reference
Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
Title
Lysosomal proteolysis in skeletal muscle.
Journal
Reference
Authors
He C, Klionsky DJ
Title
Regulation mechanisms and signaling pathways of autophagy.
Journal
Reference
Authors
Yang Z, Klionsky DJ
Title
An overview of the molecular mechanism of autophagy.
Journal
Reference
Authors
Yang Z, Klionsky DJ
Title
Mammalian autophagy: core molecular machinery and signaling regulation.
Journal
Reference
Authors
Chen Y, Klionsky DJ
Title
The regulation of autophagy - unanswered questions.
Journal
Reference
Authors
Mizushima N, Yoshimori T, Ohsumi Y
Title
The role of Atg proteins in autophagosome formation.
Journal
Reference
Authors
Russell RC, Yuan HX, Guan KL
Title
Autophagy regulation by nutrient signaling.
Journal
Reference
Authors
Noda NN, Fujioka Y
Title
Atg1 family kinases in autophagy initiation.
Journal
Related pathway
mcoc04141 Protein processing in endoplasmic reticulum
KO pathway
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