KEGG   PATHWAY: mcoc04140
Entry
mcoc04140                   Pathway                                
Name
Autophagy - animal - Mastomys coucha (southern multimammate mouse)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
mcoc04140  Autophagy - animal
mcoc04140

Other DBs
GO: 0006914
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116101481  insulin-1 [KO:K04526]
116102373  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116088647  Irs1; insulin receptor substrate 1 [KO:K16172]
116068902  Irs2; insulin receptor substrate 2 [KO:K07187]
116068604  insulin receptor substrate 1-like [KO:K17445]
116089083  Irs4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116078189  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116103746  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116072312  Mras; ras-related protein M-Ras [KO:K07831]
116102164  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
116102825  Rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116081194  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
116074523  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
116078562  Tsc2; tuberin isoform X1 [KO:K07207]
116089904  Tsc1; hamartin isoform X1 [KO:K07206]
116103150  Bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
116097567  Rheb; GTP-binding protein Rheb [KO:K07208]
116077504  Rptor; regulatory-associated protein of mTOR [KO:K07204]
116081595  Deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
116097015  Mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116102150  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
116078499  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
116103319  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
116079205  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
116098412  immunoglobulin-binding protein 1b [KO:K17606]
116087090  Igbp1; immunoglobulin-binding protein 1 [KO:K17606]
116104772  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116077586  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116068139  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
116078838  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
116090480  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
116080067  Atg101; autophagy-related protein 101 [KO:K19730]
116088140  Rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
116103443  Atg2a; autophagy-related protein 2 homolog A [KO:K17906]
116081190  Atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
116068694  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
116079011  Wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
116102776  Wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
116077256  Wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
116097544  Atg9b; autophagy-related protein 9B [KO:K17907]
116088595  Atg9a; autophagy-related protein 9A isoform X1 [KO:K17907]
116092869  Supt20h; transcription factor SPT20 homolog isoform X1 [KO:K21245]
116079133  Smcr8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
116083801  Wdr41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
116087963  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
116069541  Rab8a; ras-related protein Rab-8A [KO:K07901]
116074230  Rab39b; ras-related protein Rab-39B [KO:K07925]
116077040  Sqstm1; sequestosome-1 isoform X1 [KO:K14381]
116076589  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
116090219  Tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
116070934  Rab1a; ras-related protein Rab-1A [KO:K07874]
116096204  Rraga; ras-related GTP-binding protein A [KO:K16185]
116090000  Rragb; ras-related GTP-binding protein B isoform X1 [KO:K16185]
116095766  Rragc; ras-related GTP-binding protein C [KO:K16186]
116087990  Rragd; ras-related GTP-binding protein D isoform X1 [KO:K16186]
116076582  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
116096329  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
116083203  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116085415  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116097315  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
116091179  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
116103467  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116077067  Becn1; beclin-1 isoform X1 [KO:K08334]
116071322  Becn2; beclin-2 [KO:K08334]
116075000  Nrbf2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
116073902  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
116086936  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
116084614  Atg14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
116090484  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
116090551  Traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116091232  Tp53inp2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
116079184  Vmp1; vacuole membrane protein 1 [KO:K21248]
116095991  Stx17; syntaxin-17 [KO:K08491]
116102614  Uvrag; UV radiation resistance-associated gene protein isoform X1 [KO:K21249]
116093891  Sh3glb1; endophilin-B1 isoform X1 [KO:K11248]
116086270  Rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein [KO:K19330]
116068376  Camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
116088003  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116076830  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
116099362  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116082387  Dapk1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
116076180  Dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
116072163  Dapk2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
116104720  Hmgb1; high mobility group protein B1 [KO:K10802]
116103171  Prap1; proline-rich acidic protein 1 isoform X1 [KO:K21250]
116099053  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
116090688  Eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
116080060  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
116069401  Mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
116078953  Mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
116099386  Mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
116080649  Zfyve1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
116087137  Atg12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
116075468  Atg5; autophagy protein 5 isoform X1 [KO:K08339]
116088724  Atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
116102664  Atg16l2; autophagy-related protein 16-2 isoform X1 [KO:K20868]
116099420  Atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
116083837  Atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
116085951  Atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
116088466  Cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
116094447  Rab33b; ras-related protein Rab-33B [KO:K07920]
116081411  Prkcq; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
116099677  Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
116077104  Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
116070214  Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
116070311  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
116091231  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
116096279  Atg4c; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
116073906  Atg4d; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
116088808  Atg4b; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
116089020  Atg4a; cysteine protease ATG4A isoform X1 [KO:K08342] [EC:3.4.22.-]
116078428  Nbr1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
116081709  Optn; optineurin isoform X1 [KO:K19946]
116077340  Calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
116098931  Tax1bp1; tax1-binding protein 1 [KO:K21347]
116067978  Wdfy3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
116074216  ubiquitin-like [KO:K02927]
116069469  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
116069335  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
116082443  LOW QUALITY PROTEIN: polyubiquitin-like [KO:K04551]
116087665  ubiquitin-like [KO:K04551]
116080143  ubiquitin [KO:K04551]
116085655  Snap29; synaptosomal-associated protein 29 [KO:K08509]
116099080  Vamp8; vesicle-associated membrane protein 8 [KO:K08512]
116069911  Ykt6; synaptobrevin homolog YKT6 [KO:K08516]
116097841  Stx7; syntaxin-7 [KO:K08488]
116087383  Epg5; ectopic P granules protein 5 homolog isoform X1 [KO:K23883]
116076679  Plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
116072784  Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
116090929  Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
116090719  Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
116068397  Vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
116090757  Vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
116082714  Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
116079818  Birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
116090289  Gorasp2; Golgi reassembly-stacking protein 2 isoform X1 [KO:K26797]
116073926  Gorasp1; Golgi reassembly-stacking protein 1 isoform X1 [KO:K26797]
116099215  Rab7a; ras-related protein Rab-7a [KO:K07897]
116098920  Rab7b; ras-related protein Rab-7b [KO:K07898]
116068931  Lamp1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
116078351  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
116103240  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
116082097  cathepsin 7-like [KO:K01365] [EC:3.4.22.15]
116082227  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
116081960  cathepsin 7-like [KO:K01365] [EC:3.4.22.15]
116085396  Ctsb; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
mcoc04010  MAPK signaling pathway
mcoc04141  Protein processing in endoplasmic reticulum
mcoc04142  Lysosome
mcoc04150  mTOR signaling pathway
mcoc04152  AMPK signaling pathway
mcoc04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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