KEGG   PATHWAY: mna05225
Entry
mna05225                    Pathway                                
Name
Hepatocellular carcinoma - Miniopterus natalensis (Natal long-fingered bat)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
mna05225  Hepatocellular carcinoma
mna05225

Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107539909  IGF2; insulin-like growth factor II [KO:K13769]
107527774  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107542131  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
107524904  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
107538300  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107544745  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107540426  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
107541393  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
107543890  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
107538554  SHC2; SHC-transforming protein 2 [KO:K17447]
107529164  SHC3; SHC-transforming protein 3 [KO:K17448]
107535558  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
107536618  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107525851  SOS2; son of sevenless homolog 2 [KO:K03099]
107541780  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107525258  KRAS; GTPase KRas [KO:K07827]
107545303  NRAS; GTPase NRas [KO:K07828]
107541381  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
107531103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107525695  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107543303  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107540994  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107530082  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
107537414  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
107539805  BAD; bcl2-associated agonist of cell death [KO:K02158]
107527777  BCL2L1; bcl-2-like protein 1 [KO:K04570]
107539494  MYC; myc proto-oncogene protein [KO:K04377]
107531399  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
107527747  E2F1; transcription factor E2F1 [KO:K17454]
107538329  E2F2; transcription factor E2F2 [KO:K09389]
107539632  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
107536477  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
107538830  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
107544572  TP53; cellular tumor antigen p53 [KO:K04451]
107545578  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
107534560  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
107533887  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
107531901  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
107541604  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
107530310  DDB2; DNA damage-binding protein 2 [KO:K10140]
107531215  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
107546223  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107541691  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
107537434  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107534176  TGFB1; transforming growth factor beta-1 [KO:K13375]
107543622  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
107533843  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
107544970  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
107526381  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107546622  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
107525935  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
107546640  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
107528239  WNT1; proto-oncogene Wnt-1 [KO:K03209]
107545293  WNT2B; protein Wnt-2b [KO:K00182]
107524863  WNT2; protein Wnt-2 [KO:K00182]
107529919  WNT3A; protein Wnt-3a [KO:K00312]
107530219  WNT3; proto-oncogene Wnt-3 [KO:K00312]
107538446  WNT4; protein Wnt-4 [KO:K00408]
107546464  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
107530635  WNT5A; protein Wnt-5a [KO:K00444]
107524769  WNT6; protein Wnt-6 [KO:K00445]
107537987  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
107534839  WNT7B; protein Wnt-7b [KO:K00572]
107542524  WNT8B; protein Wnt-8b [KO:K00714]
107530103  WNT8A; protein Wnt-8a [KO:K00714]
107529865  WNT9A; protein Wnt-9a [KO:K01064]
107530990  WNT9B; protein Wnt-9b [KO:K01064]
107528238  WNT10B; protein Wnt-10b [KO:K01357]
107524821  WNT10A; protein Wnt-10a [KO:K01357]
107524451  WNT11; protein Wnt-11 [KO:K01384]
107537386  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
107541653  FZD1; frizzled-1 [KO:K02432]
107533927  FZD7; frizzled-7 [KO:K02432]
107528834  FZD2; frizzled-2 [KO:K02235]
107537768  FZD3; frizzled-3 isoform X1 [KO:K02329]
107532452  FZD4; frizzled-4 isoform X1 [KO:K02354]
107525076  FZD8; frizzled-8 [KO:K02375]
107524716  FZD5; frizzled-5 [KO:K02375]
107546030  FZD6; frizzled-6 isoform X1 [KO:K02376]
107526557  FZD9; frizzled-9 [KO:K02842]
107529641  FZD10; frizzled-10 [KO:K02842]
107537408  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
107537433  LRP5L; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5-like protein [KO:K03068]
107525309  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
107541116  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
107543696  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
107544485  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
107542516  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
107527219  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107539654  AXIN1; axin-1 isoform X1 [KO:K02157]
107538303  AXIN2; axin-2 isoform X1 [KO:K04385]
107546495  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
107534581  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
107524266  CTNNB1; catenin beta-1 [KO:K02105]
107535234  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
107525397  TCF7; transcription factor 7 isoform X1 [KO:K02620]
107528616  TCF7L1; transcription factor 7-like 1 [KO:K04490]
107536455  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
107538292  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
107533297  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
107533987  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
107545379  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
107527912  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
107537949  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
107525285  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
107545231  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
107545232  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
107536433  glutathione S-transferase omega-2-like [KO:K00799] [EC:2.5.1.18]
107534914  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
107530448  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
107536478  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
107525820  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
107525824  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
107525825  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
107525831  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
107530525  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
107530526  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
107530527  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
107537398  GSTP1; LOW QUALITY PROTEIN: glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
107537399  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
107525205  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
107545137  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
107530565  TXNRD2; thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
107527167  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
107528536  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
107532524  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
107539076  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107537600  ACTB; actin, cytoplasmic 1 [KO:K05692]
107541117  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
107540889  ACTL6B; actin-like protein 6B [KO:K11652]
107528261  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
107524901  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
107530642  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform X1 [KO:K11650]
107537020  PHF10; PHD finger protein 10 isoform X1 [KO:K22197]
107532214  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
107533463  DPF3; zinc finger protein DPF3 [KO:K22198]
107539963  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
107527811  ARID1B; AT-rich interactive domain-containing protein 1B [KO:K11653]
107538769  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
107530529  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
107529415  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
107546143  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
107533283  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
107538090  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
107528211  ARID2; AT-rich interactive domain-containing protein 2 isoform X1 [KO:K11765]
107534808  protein polybromo-1 isoform X1 [KO:K11757]
107531019  BRD7; bromodomain-containing protein 7 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
mna04010  MAPK signaling pathway
mna04020  Calcium signaling pathway
mna04110  Cell cycle
mna04115  p53 signaling pathway
mna04151  PI3K-Akt signaling pathway
mna04310  Wnt signaling pathway
mna04350  TGF-beta signaling pathway
mna04932  Non-alcoholic fatty liver disease
mna04936  Alcoholic liver disease
mna05160  Hepatitis C
mna05161  Hepatitis B
KO pathway
ko05225   
LinkDB

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