Entry
Name
Malaria - Mus pahari (shrew mouse)
Description
Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form.
Sporozoite invasion of hepatocytes is mediated by parasite surface protein like CSP. Subsequent infection into red blood cells (RBCs) by merozoites causes malaria disease via aberrant cytokine production and sequestration of parasite-infected red blood cells (pRBCs) to host endothelium. Microvasculature sequestration in the brain brings about cerebral malaria that can results in death or persisting neurological impairment. PfEMP1 has been suggested as the key adhesive molecule of pRBCs.
Class
Human Diseases; Infectious disease: parasitic
BRITE hierarchy
Pathway map
Ortholog table
Organism
Mus pahari (shrew mouse) [GN:
mpah ]
Gene
110326058 Lrp1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550 ]
110327862 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
110316390 killer cell lectin-like receptor subfamily B member 1B allele B isoform X1 [KO:K06543 ]
110316498 killer cell lectin-like receptor subfamily B member 1C [KO:K06543 ]
110316533 killer cell lectin-like receptor subfamily B member 1F [KO:K06543 ]
110315581 LOW QUALITY PROTEIN: killer cell lectin-like receptor subfamily B member 1C [KO:K06543 ]
110315592 killer cell lectin-like receptor subfamily B member 1 [KO:K06543 ]
110316921 killer cell lectin-like receptor subfamily B member 1A [KO:K06543 ]
110321621 Cr1l; complement component receptor 1-like protein isoform X1 [KO:K04011 ]
110331583 Pecam1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471 ]
110318846 Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
Compound
Reference
Authors
Morahan BJ, Wang L, Coppel RL
Title
No TRAP, no invasion.
Journal
Reference
Authors
Shakibaei M, Frevert U
Title
Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans.
Journal
Reference
Authors
Silvie O, Franetich JF, Renia L, Mazier D
Title
Malaria sporozoite: migrating for a living.
Journal
Reference
Authors
Mota MM, Giordano S, Rodriguez A
Title
Targeting Plasmodium host cells: survival within hepatocytes.
Journal
Reference
Authors
Cowman AF, Crabb BS
Title
The Plasmodium falciparum genome--a blueprint for erythrocyte invasion.
Journal
Reference
Authors
O'Donnell RA, Blackman MJ
Title
The role of malaria merozoite proteases in red blood cell invasion.
Journal
Reference
Authors
Iyer J, Gruner AC, Renia L, Snounou G, Preiser PR
Title
Invasion of host cells by malaria parasites: a tale of two protein families.
Journal
Reference
Authors
Chitnis CE
Title
Molecular insights into receptors used by malaria parasites for erythrocyte invasion.
Journal
Reference
Authors
Rasti N, Wahlgren M, Chen Q
Title
Molecular aspects of malaria pathogenesis.
Journal
Reference
Authors
Clark IA, Rockett KA, Cowden WB
Title
Proposed link between cytokines, nitric oxide and human cerebral malaria.
Journal
Reference
Authors
Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
Title
Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.
Journal
Reference
Authors
Chen Q, Schlichtherle M, Wahlgren M
Title
Molecular aspects of severe malaria.
Journal
Reference
Authors
Miller LH, Baruch DI, Marsh K, Doumbo OK
Title
The pathogenic basis of malaria.
Journal
Reference
Authors
Faille D, El-Assaad F, Alessi MC, Fusai T, Combes V, Grau GE
Title
Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding.
Journal
Reference
Authors
Schofield L, Grau GE
Title
Immunological processes in malaria pathogenesis.
Journal
Reference
Authors
Ishino T, Yano K, Chinzei Y, Yuda M
Title
Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer.
Journal
Reference
Authors
Kariu T, Ishino T, Yano K, Chinzei Y, Yuda M
Title
CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hosts.
Journal
Reference
Authors
Cox D, McConkey S
Title
The role of platelets in the pathogenesis of cerebral malaria.
Journal
Related pathway
mpah04610 Complement and coagulation cascades
mpah04620 Toll-like receptor signaling pathway
KO pathway
LinkDB
All DBs