KEGG   PATHWAY: ncar04540
Entry
ncar04540                   Pathway                                
Name
Gap junction - Sciurus carolinensis (gray squirrel)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ncar04540  Gap junction
ncar04540

Other DBs
GO: 0005921
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124989760  gap junction alpha-1 protein [KO:K07372]
124977535  gap junction delta-2 protein [KO:K07373]
124964952  lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
124992673  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124988012  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124991078  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124970285  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
124982576  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
124994986  platelet-derived growth factor C isoform X1 [KO:K05450]
124960701  platelet-derived growth factor D isoform X1 [KO:K05450]
124994951  pro-epidermal growth factor-like isoform X1 [KO:K04357]
124995024  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
124986803  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
124990601  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
124980188  growth factor receptor-bound protein 2 [KO:K04364]
124977045  son of sevenless homolog 2 [KO:K03099]
124963384  son of sevenless homolog 1 isoform X1 [KO:K03099]
124974041  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
124958599  GTPase HRas isoform X1 [KO:K02833]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124962389  GTPase NRas [KO:K07828]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124969568  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124977049  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
124979813  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
124973399  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
124980909  mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
124990413  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
124990575  tubulin alpha-3 chain [KO:K07374]
124990878  tubulin alpha-3 chain [KO:K07374]
124992512  tubulin alpha-1A chain-like [KO:K07374]
124978858  tubulin alpha-1D chain [KO:K07374]
124978859  tubulin alpha-4A chain [KO:K07374]
124961678  tubulin alpha-8 chain isoform X1 [KO:K07374]
124961964  tubulin alpha chain-like 3 [KO:K07374]
124982222  tubulin alpha-1B chain isoform X1 [KO:K07374]
124982223  tubulin alpha-1A chain [KO:K07374]
124982391  tubulin alpha-8 chain [KO:K07374]
124986665  tubulin beta chain-like [KO:K07375]
124988071  tubulin beta chain [KO:K07375]
124988155  tubulin beta-2A chain [KO:K07375]
124989446  tubulin beta-2A chain-like [KO:K07375]
124989671  tubulin beta-2B chain [KO:K07375]
124990586  tubulin beta chain-like [KO:K07375]
124968782  tubulin beta-4A chain [KO:K07375]
124978255  tubulin beta-1 chain [KO:K07375]
124964452  tubulin beta-4B chain [KO:K07375]
124965280  tubulin beta-5 chain [KO:K07375]
124966012  tubulin beta-3 chain [KO:K07375]
124980668  casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
124984914  LOW QUALITY PROTEIN: cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
124975977  tight junction protein ZO-1 isoform X1 [KO:K05701]
124985454  beta-1 adrenergic receptor [KO:K04141]
124987160  LOW QUALITY PROTEIN: D(1A) dopamine receptor-like [KO:K04144]
124978161  neuroendocrine secretory protein 55 [KO:K04632]
124975134  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
124959858  D(2) dopamine receptor [KO:K04145]
124990345  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
124987010  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
124962927  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
124978229  LOW QUALITY PROTEIN: adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
124992559  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124983776  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
124966834  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
124965096  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124970113  LOW QUALITY PROTEIN: adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
124985819  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124969119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124984942  5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
124979674  5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
124972402  5-hydroxytryptamine receptor 2C [KO:K04157]
124989681  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
124958602  metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
124968563  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
124964255  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
124976705  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
124959812  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
124977474  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
124972679  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
124970932  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
124983533  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
124988553  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
124979014  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124970211  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
124967611  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
124994911  guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
124959976  guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
124985555  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
124995059  guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
124984630  cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
ncar04010  MAPK signaling pathway
ncar04020  Calcium signaling pathway
ncar04060  Cytokine-cytokine receptor interaction
ncar04070  Phosphatidylinositol signaling system
ncar04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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