KEGG   PATHWAY: ncar04726
Entry
ncar04726                   Pathway                                
Name
Serotonergic synapse - Sciurus carolinensis (gray squirrel)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
ncar04726  Serotonergic synapse
ncar04726

Other DBs
GO: 0007210
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124960036  tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
124983401  tryptophan 5-hydroxylase 2 isoform X1 [KO:K00502] [EC:1.14.16.4]
124990854  aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
124984605  synaptic vesicular amine transporter [KO:K08155]
124983739  chromaffin granule amine transporter-like [KO:K08155]
124982084  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
124968359  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
124971751  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
124961645  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
124984942  5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
124979674  5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
124972402  5-hydroxytryptamine receptor 2C [KO:K04157]
124964255  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
124976705  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
124959812  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
124977474  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
124972679  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
124970932  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
124983533  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
124988553  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
124979014  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124970211  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
124967611  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124976716  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
124976990  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
124978216  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
124978217  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
124962073  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
124974890  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
124985776  cytochrome P450 2C9-like [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
124985913  cytochrome P450 2C18-like [KO:K17720] [EC:1.14.14.1]
124984715  cytochrome P450 2C18 [KO:K17720] [EC:1.14.14.1]
124985911  cytochrome P450 2C9-like [KO:K07413] [EC:1.14.14.1]
124985912  cytochrome P450 2C18-like isoform X1 [KO:K07413] [EC:1.14.14.1]
124985914  cytochrome P450 2C9-like [KO:K07413] [EC:1.14.14.1]
124984664  cytochrome P450 2C18-like [KO:K07413] [EC:1.14.14.1]
124984711  LOW QUALITY PROTEIN: cytochrome P450 2C18-like [KO:K07413] [EC:1.14.14.1]
124984718  cytochrome P450 2C9-like [KO:K07413] [EC:1.14.14.1]
124984740  cytochrome P450 2C9-like isoform X1 [KO:K07413] [EC:1.14.14.1]
124984981  cytochrome P450 2C55-like [KO:K07413] [EC:1.14.14.1]
124985051  cytochrome P450 2C9-like [KO:K07413] [EC:1.14.14.1]
124985100  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
124985193  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
124985263  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
124985323  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
124982053  cytochrome P450 2D14-like isoform X1 [KO:K07414] [EC:1.14.14.1]
124982056  cytochrome P450 2D14-like isoform X1 [KO:K07414] [EC:1.14.14.1]
124966849  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
124992327  cytochrome P450 4X1-like [KO:K07428] [EC:1.14.14.1]
124985624  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
124985161  LOW QUALITY PROTEIN: polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
124985243  LOW QUALITY PROTEIN: polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
124975507  LOW QUALITY PROTEIN: polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
124979056  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1 [KO:K00458] [EC:1.13.11.31]
124980537  LOW QUALITY PROTEIN: polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type-like [KO:K00458] [EC:1.13.11.31]
124980267  arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
124980592  LOW QUALITY PROTEIN: polyunsaturated fatty acid lipoxygenase ALOX15-like [KO:K00460] [EC:1.13.11.33]
124980374  polyunsaturated fatty acid lipoxygenase ALOX15B-like isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
124964706  prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
124962420  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
124993276  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3E-like [KO:K04819]
124960132  5-hydroxytryptamine receptor 3A [KO:K04819]
124960603  5-hydroxytryptamine receptor 3B-like [KO:K04819]
124986375  5-hydroxytryptamine receptor 4 [KO:K04160]
124994553  5-hydroxytryptamine receptor 6 [KO:K04162]
124985108  5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
124978161  neuroendocrine secretory protein 55 [KO:K04632]
124975134  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
124992559  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124985819  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124969119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124987171  small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
124974405  small conductance calcium-activated potassium channel protein 2-like [KO:K04943]
124975662  LOW QUALITY PROTEIN: small conductance calcium-activated potassium channel protein 2-like [KO:K04943]
124990422  potassium voltage-gated channel subfamily D member 2 [KO:K04892]
124994665  gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
124987594  LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit beta-2-like [KO:K05181]
124971099  gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
124982354  rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
124993088  amyloid-beta precursor protein isoform X1 [KO:K04520]
124987250  5-hydroxytryptamine receptor 1A [KO:K04153]
124987985  5-hydroxytryptamine receptor 1B [KO:K04153]
124989763  5-hydroxytryptamine receptor 1E [KO:K04153]
124992342  5-hydroxytryptamine receptor 1F [KO:K04153]
124960431  5-hydroxytryptamine receptor 1D [KO:K04153]
124990222  5-hydroxytryptamine receptor 5A [KO:K04161]
124978891  5-hydroxytryptamine receptor 5B [KO:K04161]
124992673  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124988012  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124991078  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124967520  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
124976089  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
124969987  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
124993231  guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
124978030  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
124960444  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
124961969  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
124978139  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
124961463  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
124961876  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
124965653  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
124968657  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
124967414  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
124970655  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
124964520  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
124975713  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
124991054  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
124993726  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
124969192  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
124990131  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
124980134  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
124972492  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
124983898  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
124987585  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
124958599  GTPase HRas isoform X1 [KO:K02833]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124962389  GTPase NRas [KO:K07828]
124971762  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
124990234  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124969155  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
124964767  voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
124980509  G protein-activated inward rectifier potassium channel 1 [KO:K04997]
124993028  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
124990924  G protein-activated inward rectifier potassium channel 3 [KO:K05002]
124960772  G protein-activated inward rectifier potassium channel 4 isoform X1 [KO:K04999]
124993142  short transient receptor potential channel 1 isoform X1 [KO:K04964]
124980025  sodium-dependent serotonin transporter [KO:K05037]
124971911  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
124972466  LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
ncar00380  Tryptophan metabolism
ncar00590  Arachidonic acid metabolism
ncar04020  Calcium signaling pathway
ncar04721  Synaptic vesicle cycle
ncar04976  Bile secretion
KO pathway
ko04726   
LinkDB

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