KEGG   PATHWAY: ola00310
Entry
ola00310                    Pathway                                
Name
Lysine degradation - Oryzias latipes (Japanese medaka)
Class
Metabolism; Amino acid metabolism
Pathway map
ola00310  Lysine degradation
ola00310

Module
ola_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:ola00310]
Other DBs
GO: 0006554
Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
101155996  aass; alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1 [KO:K14157] [EC:1.5.1.8 1.5.1.9]
101157525  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase isoform X2 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101156284  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X2 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
101175318  dhtkd1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
101166427  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
101168947  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
101166964  gcdh; glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
101155646  hadha; trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
101170799  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
101170209  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
101166688  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
101172558  acat1; acetyl-CoA acetyltransferase, mitochondrial isoform X1 [KO:K00626] [EC:2.3.1.9]
101175699  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
101157673  hykk; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
101162691  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
101160829  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101157242  camkmt; calmodulin-lysine N-methyltransferase isoform X1 [KO:K18826] [EC:2.1.1.60]
101171020  kmt2a; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
101172242  kmt2d; histone-lysine N-methyltransferase 2D isoform X1 [KO:K09187] [EC:2.1.1.354]
101162786  histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
101171448  histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
101174945  kmt2b; histone-lysine N-methyltransferase 2B isoform X1 [KO:K14959] [EC:2.1.1.354]
101157226  histone-lysine N-methyltransferase 2B [KO:K14959] [EC:2.1.1.354]
101162568  kmt2e; histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
101168786  histone-lysine N-methyltransferase SETD1A [KO:K11422] [EC:2.1.1.354]
101162384  setd1b; histone-lysine N-methyltransferase SETD1B isoform X1 [KO:K11422] [EC:2.1.1.354]
101168630  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
101168249  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
101156847  ash1l; histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
101161417  histone-lysine N-methyltransferase ASH1L isoform X2 [KO:K06101] [EC:2.1.1.354]
101169349  smyd3; histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101161247  histone-lysine N-methyltransferase SMYD1 isoform X2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101164768  smyd2; N-lysine methyltransferase SMYD2 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101173073  histone-lysine N-methyltransferase Smyd1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101159335  N-lysine methyltransferase SMYD2-A [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101155408  suv39h1; histone-lysine N-methyltransferase SUV39H1 isoform X1 [KO:K11419] [EC:2.1.1.355]
101171173  histone-lysine N-methyltransferase EHMT1 isoform X1 [KO:K11420] [EC:2.1.1.355]
101167635  histone-lysine N-methyltransferase EHMT1 isoform X1 [KO:K11420] [EC:2.1.1.355]
101167716  ehmt2; histone-lysine N-methyltransferase EHMT2 [KO:K11420] [EC:2.1.1.355]
101158302  setdb1; histone-lysine N-methyltransferase SETDB1 [KO:K11421] [EC:2.1.1.366]
101163233  histone-lysine N-methyltransferase SETDB2 isoform X1 [KO:K18494] [EC:2.1.1.355]
101156736  PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
101157610  prdm2; PR domain zinc finger protein 2 isoform X1 [KO:K11432] [EC:2.1.1.355]
101166385  ezh1; histone-lysine N-methyltransferase EZH1 [KO:K17451] [EC:2.1.1.356]
100125823  ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
101172575  histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
101160669  histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [KO:K15588] [EC:2.1.1.357]
101161079  histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X2 [KO:K15588] [EC:2.1.1.357]
101172132  nsd2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
101156018  nsd3; histone-lysine N-methyltransferase NSD3 isoform X1 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
101163764  setd2; histone-lysine N-methyltransferase SETD2 isoform X1 [KO:K11423] [EC:2.1.1.359]
101166952  dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
101172663  N-lysine methyltransferase KMT5A isoform X4 [KO:K11428] [EC:2.1.1.361]
101169793  kmt5a; N-lysine methyltransferase KMT5A isoform X1 [KO:K11428] [EC:2.1.1.361]
105354834  prdm6; putative histone-lysine N-methyltransferase PRDM6 [KO:K20795] [EC:2.1.1.361]
101165555  uncharacterized protein LOC101165555 [KO:K11429] [EC:2.1.1.362]
101156070  kmt5b; histone-lysine N-methyltransferase KMT5B isoform X1 [KO:K11429] [EC:2.1.1.362]
101169474  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
101156011  prdm16; PR domain zinc finger protein 16 isoform X1 [KO:K22410] [EC:2.1.1.367]
101160186  tmlhe; trimethyllysine dioxygenase, mitochondrial [KO:K00474] [EC:1.14.11.8]
101156839  fatty aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
101172271  aldh2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
101160930  fatty aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
101170591  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
100049493  aldh9a1; aldehyde dehydrogenase family 9 member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
101155544  aldehyde dehydrogenase family 9 member A1-B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
101162990  bbox1; gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
101160794  plod1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [KO:K00473] [EC:1.14.11.4]
101171207  plod2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X2 [KO:K13645] [EC:1.14.11.4]
101154842  plod3; procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 isoform X1 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
101160659  procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
101162193  colgalt1; procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
101156942  cercam; inactive glycosyltransferase 25 family member 3 [KO:K11703] [EC:2.4.1.50]
101161789  procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
ola00020  Citrate cycle (TCA cycle)
ola00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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