KEGG   PATHWAY: osa03410
Entry
osa03410                    Pathway                                
Name
Base excision repair - Oryza sativa japonica (Japanese rice)
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
osa03410  Base excision repair
osa03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Oryza sativa japonica (Japanese rice) [GN:osa]
Gene
112936215  [KO:K03505]
136351165  [KO:K01247] [EC:3.2.2.21]
4326478  [KO:K28005]
4326479  ADPRT-2-A; poly [ADP-ribose] polymerase 2-A [KO:K28005]
4327080  [KO:K03504]
4327631  [KO:K01246] [EC:3.2.2.20]
4327876  [KO:K08073] [EC:3.1.3.32 2.7.1.78]
4327960  [KO:K01142] [EC:3.1.11.2]
4327961  [KO:K01142] [EC:3.1.11.2]
4329458  [KO:K02324] [EC:2.7.7.7]
4329546  ADPRT-3; protein ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.-]
4330890  [KO:K03652] [EC:3.2.2.21]
4330895  OsRFC3; replication factor C subunit 3 [KO:K10756]
4331062  Cyclin; proliferating cell nuclear antigen [KO:K04802]
4331489  OJ1528D07.1; DNA polymerase delta small subunit [KO:K02328]
4332518  [KO:K10863] [EC:3.6.1.70 3.6.1.71 3.6.1.72]
4334389  OsJ_12910; replication factor C subunit 5 [KO:K10756]
4334691  FEN1B; flap endonuclease 1-B [KO:K04799] [EC:3.1.-.-]
4334754  [KO:K07759] [EC:3.2.1.143]
4336309  [KO:K01246] [EC:3.2.2.20]
4336704  OsRFC4; replication factor C subunit 4 [KO:K10755]
4337150  [KO:K02335] [EC:2.7.7.7]
4337373  [KO:K03648] [EC:3.2.2.27]
4337886  [KO:K02325] [EC:2.7.7.7]
4339464  FEN1A; flap endonuclease 1-A [KO:K04799] [EC:3.1.-.-]
4339711  [KO:K01247] [EC:3.2.2.21]
4340098  xrcc1; DNA-repair protein XRCC1 isoform X1 [KO:K10803]
4340604  OsPolL; dNA polymerase lambda [KO:K03512] [EC:2.7.7.7 4.2.99.-]
4340610  [KO:K10773] [EC:3.2.2.- 4.2.99.18]
4341640  [KO:K10563] [EC:3.2.2.23 4.2.99.18]
4341682  [KO:K01246] [EC:3.2.2.20]
4343013  ADPRT-1; poly [ADP-ribose] polymerase 1 [KO:K24070]
4343446  [KO:K10862] [EC:3.1.4.-]
4344737  [KO:K03505]
4344789  OsJ_26226; DNA polymerase I A, chloroplastic [KO:K02335] [EC:2.7.7.7]
4344791  [KO:K02335] [EC:2.7.7.7]
4345225  [KO:K10563] [EC:3.2.2.23 4.2.99.18]
4346365  [KO:K10801] [EC:3.2.2.-]
4347081  [KO:K01246] [EC:3.2.2.20]
4347604  P0669G04.6; uncharacterized LOC4347604 [KO:K03505]
4347894  [KO:K02326] [EC:2.7.7.7]
4348965  [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
4349480  [KO:K10756]
4349968  OspolD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
4350754  OsRFC1; replication factor C subunit 1 [KO:K10754]
4351654  OsJ_35406; replication factor C subunit 2 [KO:K10755]
4351781  [KO:K03575] [EC:3.2.2.31]
9268162  [KO:K10773] [EC:3.2.2.- 4.2.99.18]
9269803  [KO:K03575] [EC:3.2.2.31]
9272626  [KO:K01246] [EC:3.2.2.20]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   

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