Entry Name Central carbon metabolism in cancer - Puma concolor (puma)
Description Malignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamental differences in the central metabolic pathways operating in malignant tissue. He showed that cancer cells consume a large amount of glucose, maintain high rate of glycolysis and convert a majority of glucose into lactic acid even under normal oxygen concentrations (Warburg's Effects). More recently, it has been recognized that the 'Warburg effect' encompasses a similarly increased utilization of glutamine. From the intermediate molecules provided by enhanced glycolysis and glutaminolysis, cancer cells synthesize most of the macromolecules required for the duplication of their biomass and genome. These cancer-specific alterations represent a major consequence of genetic mutations and the ensuing changes of signalling pathways in cancer cells. Three transcription factors, c-MYC, HIF-1 and p53, are key regulators and coordinate regulation of cancer metabolism in different ways, and many other oncogenes and tumor suppressor genes cluster along the signaling pathways that regulate c-MYC, HIF-1 and p53.
Class Human Diseases; Cancer: overviewBRITE hierarchy
Pathway map pcoo05230 Central carbon metabolism in cancer
Ortholog table Organism Puma concolor (puma) [GN:
pcoo ]
Gene 112863407 SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299 ]
112849531 SLC2A2; solute carrier family 2, facilitated glucose transporter member 2 [KO:K07593 ]
112858492 PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
112871680 PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
112852567 PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
112871012 PDK1; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial [KO:K12077 ] [EC:2.7.11.2 ]
112856999 TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451 ]
112865883 LOW QUALITY PROTEIN: protein SCO2 homolog, mitochondrial [KO:K23755 ]
112849397 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
112849524 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
112848856 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
112861619 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
112868847 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
112857536 SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780 ]
Compound C00354 D-Fructose 1,6-bisphosphate
C00665 beta-D-Fructose 2,6-bisphosphate
Reference Authors Soga T
Title Cancer metabolism: key players in metabolic reprogramming.
Journal Reference Authors Vander Heiden MG, Cantley LC, Thompson CB
Title Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Journal Reference Authors Teicher BA, Linehan WM, Helman LJ
Title Targeting cancer metabolism.
Journal Reference Authors Levine AJ, Puzio-Kuter AM
Title The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.
Journal Reference Authors Amoedo ND, Valencia JP, Rodrigues MF, Galina A, Rumjanek FD
Title How does the metabolism of tumour cells differ from that of normal cells.
Journal Reference Authors Cairns RA, Harris IS, Mak TW
Title Regulation of cancer cell metabolism.
Journal Reference Authors Munoz-Pinedo C, El Mjiyad N, Ricci JE
Title Cancer metabolism: current perspectives and future directions.
Journal Reference Authors Cairns RA, Harris I, McCracken S, Mak TW
Title Cancer cell metabolism.
Journal Reference Authors Kroemer G, Pouyssegur J
Title Tumor cell metabolism: cancer's Achilles' heel.
Journal Reference Authors DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB
Title The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
Journal Reference Authors Koppenol WH, Bounds PL, Dang CV
Title Otto Warburg's contributions to current concepts of cancer metabolism.
Journal Reference Authors Fogg VC, Lanning NJ, Mackeigan JP
Title Mitochondria in cancer: at the crossroads of life and death.
Journal Reference Authors Kim JW, Dang CV
Title Cancer's molecular sweet tooth and the Warburg effect.
Journal Reference Authors Yeung SJ, Pan J, Lee MH
Title Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer.
Journal Reference Authors Li B, Simon MC
Title Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer.
Journal Reference Authors Shen L, Sun X, Fu Z, Yang G, Li J, Yao L
Title The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy.
Journal Reference Authors Jones RG, Thompson CB
Title Tumor suppressors and cell metabolism: a recipe for cancer growth.
Journal Reference Authors Maddocks OD, Vousden KH
Title Metabolic regulation by p53.
Journal Reference Authors Chen JQ, Russo J
Title Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells.
Journal Reference Authors Kaelin WG Jr, Thompson CB
Title Q&A: Cancer: clues from cell metabolism.
Journal Reference Authors Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G
Title Metabolic targets for cancer therapy.
Journal Reference Authors Phan LM, Yeung SC, Lee MH
Title Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies.
Journal Reference Authors Icard P, Poulain L, Lincet H
Title Understanding the central role of citrate in the metabolism of cancer cells.
Journal Reference Authors Daye D, Wellen KE
Title Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.
Journal Reference Authors Chiarugi A, Dolle C, Felici R, Ziegler M
Title The NAD metabolome--a key determinant of cancer cell biology.
Journal Reference Authors Guarente L
Title The many faces of sirtuins: Sirtuins and the Warburg effect.
Journal Reference Authors Fuchs BC, Bode BP
Title Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
Journal Related pcoo00250 Alanine, aspartate and glutamate metabolism
pcoo00260 Glycine, serine and threonine metabolism
KO pathway LinkDB All DBs
