KEGG   PATHWAY: pcoo04010
Entry
pcoo04010                   Pathway                                
Name
MAPK signaling pathway - Puma concolor (puma)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcoo04010  MAPK signaling pathway
pcoo04010

Other DBs
GO: 0000165
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112852304  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
112860864  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
112867221  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
112852481  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
112857627  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
112871144  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
112852574  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
112863441  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
112857700  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112866861  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
112852458  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
112852483  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
112867179  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
112854031  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
112867395  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
112867502  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
112848734  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
112863347  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
112853308  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
112864468  CACNG4; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
112864469  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
112850910  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
112852313  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112871920  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112864470  PRKCA; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112853117  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112850908  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112848961  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112852984  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112869884  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
112858792  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
112854258  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112861555  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112869328  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
112855114  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
112861000  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
112855224  RASGRP1; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1 [KO:K04350]
112864119  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
112859075  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
112855244  NF1; neurofibromin [KO:K08052]
112861428  RASA1; ras GTPase-activating protein 1 [KO:K04352]
112849437  RASA2; ras GTPase-activating protein 2 [KO:K08053]
112848655  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
112863816  RAP1B; ras-related protein Rap-1b [KO:K07836]
112858016  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112869672  TGFA; protransforming growth factor alpha [KO:K08774]
112858736  EREG; proepiregulin [KO:K09784]
112859021  AREG; amphiregulin [KO:K09782]
112861306  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
112855096  FGF7; fibroblast growth factor 7 [KO:K04358]
112869913  FGF20; fibroblast growth factor 20 [KO:K04358]
112869983  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112870825  FGF16; fibroblast growth factor 16 [KO:K04358]
112858559  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112860871  FGF9; fibroblast growth factor 9 [KO:K04358]
112867668  FGF6; fibroblast growth factor 6 [KO:K04358]
112851220  FGF21; fibroblast growth factor 21 [KO:K22429]
112867914  FGF23; fibroblast growth factor 23 [KO:K22428]
112872060  NGF; beta-nerve growth factor [KO:K02582]
112865997  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
112867571  NTF3; neurotrophin-3 [KO:K04356]
112851175  NTF4; neurotrophin-4 [KO:K12457]
112863499  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112863445  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112858328  PDGFC; platelet-derived growth factor C [KO:K05450]
112865896  PDGFD; platelet-derived growth factor D [KO:K05450]
112871949  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
112863299  KITLG; kit ligand [KO:K05461]
112850804  FLT3LG; LOW QUALITY PROTEIN: fms-related tyrosine kinase 3 ligand [KO:K05454]
112862794  VEGFA; vascular endothelial growth factor A [KO:K05448]
112851906  VEGFB; vascular endothelial growth factor B [KO:K16858]
112856270  PGF; placenta growth factor isoform X1 [KO:K16859]
112869936  VEGFC; vascular endothelial growth factor C [KO:K05449]
112871693  VEGFD; vascular endothelial growth factor D [KO:K05449]
112866583  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112859408  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
112869986  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
112869557  ANGPT4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
112851620  ephrin-A4-like [KO:K05462]
112860543  EFNA5; LOW QUALITY PROTEIN: ephrin-A5 [KO:K05462]
112861270  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112853031  PSPN; persephin [KO:K25416]
112860068  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112854095  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112863755  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112866849  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
112858029  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112854765  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
112860952  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
112868641  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
112852904  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
112855479  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
112858116  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112860921  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112860488  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112858022  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
112860856  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112860716  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
112858053  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112866634  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
112856283  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
112861861  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
112854345  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
112864567  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
112855446  SOS2; son of sevenless homolog 2 [KO:K03099]
112864130  SOS1; son of sevenless homolog 1 [KO:K03099]
112868012  KRAS; GTPase KRas isoform X1 [KO:K07827]
112848478  NRAS; GTPase NRas [KO:K07828]
112865645  RRAS2; ras-related protein R-Ras2 [KO:K07830]
112866321  LOW QUALITY PROTEIN: ras-related protein R-Ras2-like [KO:K07830]
112849549  MRAS; ras-related protein M-Ras [KO:K07831]
112870575  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112866443  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112859466  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112855545  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112852828  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112858097  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
112856394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112870302  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112848719  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
112849257  RPS6KA2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
112870736  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
112871593  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
112871992  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
112863930  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112870581  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
112857826  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
112859511  MYC; myc proto-oncogene protein [KO:K04377]
112862470  SRF; serum response factor [KO:K04378]
112854981  FOS; proto-oncogene c-Fos [KO:K04379]
112862026  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
112870320  STMN1; stathmin [KO:K04381]
112855015  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
112855609  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
112856065  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
112856246  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
112857937  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
112853630  TNF; tumor necrosis factor [KO:K03156]
112864204  IL1A; interleukin-1 alpha [KO:K04383]
112864068  IL1B; interleukin-1 beta [KO:K04519]
112850697  TGFB1; transforming growth factor beta-1 [KO:K13375]
112864785  TGFB2; transforming growth factor beta-2 [KO:K13376]
112855350  TGFB3; transforming growth factor beta-3 [KO:K13377]
112867910  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112868908  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
112849639  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
112851426  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112850049  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112863203  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112851504  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112860205  CD14; monocyte differentiation antigen CD14 [KO:K04391]
112859959  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112863355  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112872162  CDC42; cell division control protein 42 homolog [KO:K04393]
112870035  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112860577  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112862436  DAXX; death domain-associated protein 6 [KO:K02308]
112850482  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112870846  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
112867801  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112865434  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112867941  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
112863443  TAB1; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112862397  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112852285  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
112864131  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
112869618  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
112851288  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
112865943  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
112850498  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
112868974  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
112859299  STK3; serine/threonine-protein kinase 3 [KO:K04412]
112867639  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
112860595  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
112851937  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
112865537  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
112864457  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
112855300  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
112851311  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
112851493  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
112867283  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
112849671  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
112871861  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
112862597  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
112862885  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112861992  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112862214  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
112856015  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
112870198  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
112854487  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
112857039  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
112857077  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112864599  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112865069  MAPK8IP1; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
112863378  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
112853215  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
112871097  FLNA; filamin-A [KO:K04437]
112870314  CRKL; crk-like protein [KO:K04438]
112854202  CRK; adapter molecule crk isoform X1 [KO:K04438]
112865543  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
112859092  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112854846  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112861322  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112862836  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112862837  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
112863384  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112870502  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
112857691  MAPKAPK2; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
112852461  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
112855001  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
112869246  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
112857223  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112872218  JUN; transcription factor AP-1 [KO:K04448]
112848765  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112856999  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
112863246  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
112856021  MAX; protein max isoform X1 [KO:K04453]
112861283  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
112860084  HSPB1; heat shock protein beta-1 [KO:K04455]
112863208  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112851313  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112856409  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
112863260  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
112865627  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
112861350  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
112869862  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112864236  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112852469  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112854293  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112867597  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112863582  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
112871188  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
112864838  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
112850744  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
112869159  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
112865282  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
112853784  heat shock 70 kDa protein 1-like [KO:K03283]
112853785  heat shock 70 kDa protein 1-like [KO:K03283]
112850489  MECOM; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
112855113  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
112857063  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
112867470  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
112854134  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
112854253  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112858003  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112871176  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112853429  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
112858048  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112854307  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
112851941  RELA; transcription factor p65 [KO:K04735]
112850717  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pcoo04070  Phosphatidylinositol signaling system
pcoo04110  Cell cycle
pcoo04115  p53 signaling pathway
pcoo04210  Apoptosis
pcoo04310  Wnt signaling pathway
pcoo04668  TNF signaling pathway
KO pathway
ko04010   
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