KEGG   PATHWAY: pcw04110
Entry
pcw04110                    Pathway                                
Name
Cell cycle - Phascolarctos cinereus (koala)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
pcw04110  Cell cycle
pcw04110

Other DBs
GO: 0000278
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110197171  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110218698  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110203289  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110210989  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110209152  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
110213446  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
110211462  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
110207491  RBL2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
110198907  ABL1; LOW QUALITY PROTEIN: tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
110206263  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
110222906  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
110216806  E2F1; transcription factor E2F1 [KO:K17454]
110206051  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
110208713  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
110210428  E2F4; transcription factor E2F4 [KO:K04682]
110214683  E2F5; transcription factor E2F5 [KO:K04682]
110193404  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
110197252  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
110208073  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110202366  TGFB1; transforming growth factor beta-1 [KO:K13375]
110205565  TGFB2; LOW QUALITY PROTEIN: transforming growth factor beta-2 [KO:K13376]
110208305  TGFB3; transforming growth factor beta-3 [KO:K13377]
110207982  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110205871  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
110198138  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
110216083  MYC; myc proto-oncogene protein [KO:K04377]
110198716  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
110201193  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
110201194  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
110209335  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
110214155  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
110218707  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
110197182  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
110217257  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
110207433  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
110195790  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110210908  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110211724  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
110201672  CUL1; cullin-1 [KO:K03347]
110205825  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
110214774  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
110222963  CCNA2; cyclin-A2 [KO:K06627]
110195227  CCNA1; LOW QUALITY PROTEIN: cyclin-A1 [KO:K06627]
110220000  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
110215921  CDC6; LOW QUALITY PROTEIN: cell division control protein 6 homolog [KO:K02213]
110210486  CDT1; LOW QUALITY PROTEIN: DNA replication factor Cdt1 [KO:K10727]
110209349  ORC1; origin recognition complex subunit 1 [KO:K02603]
110197247  ORC2; origin recognition complex subunit 2 [KO:K02604]
110200898  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
110207163  ORC4; LOW QUALITY PROTEIN: origin recognition complex subunit 4 [KO:K02606]
110206989  ORC5; LOW QUALITY PROTEIN: origin recognition complex subunit 5 [KO:K02607]
110207444  ORC6; origin recognition complex subunit 6 [KO:K02608]
110204932  MCM2; LOW QUALITY PROTEIN: DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
110213571  MCM3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
110212577  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
110205713  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
110223778  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
110202832  MCM7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
110215120  CDC45; LOW QUALITY PROTEIN: cell division control protein 45 homolog [KO:K06628]
110193282  TICRR; treslin isoform X1 [KO:K26117]
110193304  MTBP; mdm2-binding protein [KO:K26116]
110200218  CDC7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
110209184  DBF4; LOW QUALITY PROTEIN: protein DBF4 homolog A [KO:K06629]
110215915  DBF4B; protein DBF4 homolog B [KO:K06629]
110216425  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
110216613  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
110205363  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
110202696  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
110218356  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
110220848  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
110196285  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
110212616  YWHAQ; 14-3-3 protein theta [KO:K16197]
110206594  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
110222135  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
110221241  YWHAG; LOW QUALITY PROTEIN: 14-3-3 protein gamma [KO:K16198]
110215262  YWHAH; 14-3-3 protein eta [KO:K16198]
110202459  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
110216154  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
110218977  WEE1; wee1-like protein kinase isoform X1 [KO:K06632] [EC:2.7.11.1]
110214562  PKMYT1; LOW QUALITY PROTEIN: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
110222853  CCNH; cyclin-H [KO:K06634]
110216608  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
110209267  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
110205265  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
110215767  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
110212365  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
110196785  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
110193407  CDC16; cell division cycle protein 16 homolog [KO:K03353]
110196803  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
110220918  CDC23; LOW QUALITY PROTEIN: cell division cycle protein 23 homolog [KO:K03355]
110202280  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
110218278  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
110193688  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
110208197  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
110195211  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
110203665  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
110200195  CDC20; cell division cycle protein 20 homolog isoform X1 [KO:K03363]
110212368  PTTG1; securin [KO:K06635]
110194100  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
110193335  SMC1A; structural maintenance of chromosomes protein 1A [KO:K06636]
110201639  SMC1B; LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 1B [KO:K06636]
110209496  SMC3; structural maintenance of chromosomes protein 3 isoform X1 [KO:K06669]
110193569  RAD21; LOW QUALITY PROTEIN: double-strand-break repair protein rad21 homolog [KO:K06670]
110208203  STAG1; cohesin subunit SA-1 [KO:K06671]
110212737  LOW QUALITY PROTEIN: cohesin subunit SA-2-like [KO:K06671]
110200949  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
110193028  ATRX; transcriptional regulator ATRX isoform X1 [KO:K10779]
110218683  DDX11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
110214850  NIPBL; LOW QUALITY PROTEIN: nipped-B-like protein [KO:K06672]
110196188  MAU2; MAU2 chromatid cohesion factor homolog [KO:K11266]
110221690  HDAC8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
110206539  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
110197078  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
110215572  PDS5B; LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
110213092  PDS5A; LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
110213995  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
110195323  CDCA5; sororin isoform X1 [KO:K17390]
110194463  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
110209033  SGO1; LOW QUALITY PROTEIN: shugoshin 1 [KO:K11580]
110194908  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
110223036  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
110211727  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110219910  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
110210692  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
110222677  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
110195321  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
110197331  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
110201274  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
110208451  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
110197081  NDC80; kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
110223688  KNL1; LOW QUALITY PROTEIN: kinetochore scaffold 1 [KO:K11542]
110200293  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
110200097  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
110223033  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
110199142  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
110192734  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
110209452  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
110207910  TRIP13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
110201271  MAD2L1BP; MAD2L1-binding protein isoform X1 [KO:K26093]
110196233  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
110208565  FBXO5; LOW QUALITY PROTEIN: F-box only protein 5 [KO:K10292]
110217497  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
110197627  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
110205826  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110214481  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
110212506  PRKDC; LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
110197214  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
110214947  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
110211045  MDM2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110194271  TP53; cellular tumor antigen p53 [KO:K04451]
110212964  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
110223449  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110195907  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110207637  PCNA; proliferating cell nuclear antigen [KO:K04802]
110205971  SFN; 14-3-3 protein sigma [KO:K06644]
110218134  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
110215254  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
110217106  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
pcw03030  DNA replication
pcw04010  MAPK signaling pathway
pcw04120  Ubiquitin mediated proteolysis
pcw04210  Apoptosis
KO pathway
ko04110   
LinkDB

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