KEGG   PATHWAY: plep04140
Entry
plep04140                   Pathway                                
Name
Autophagy - animal - Plectropomus leopardus (leopard coralgrouper)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
plep04140  Autophagy - animal
plep04140

Other DBs
GO: 0006914
Organism
Plectropomus leopardus (leopard coralgrouper) [GN:plep]
Gene
121948354  insb; preproinsulin b [KO:K04526]
121938184  ins; insulin [KO:K04526]
121941149  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
121949679  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121952980  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
121939025  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
121949440  irs2b; insulin receptor substrate 2 [KO:K07187]
121961832  insulin receptor substrate 2-B [KO:K07187]
121962687  insulin receptor substrate 2-like [KO:K07187]
121947071  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121942910  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121951130  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121963985  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
121939825  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121959511  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
121951302  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121938061  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
121962939  pik3r3b; LOW QUALITY PROTEIN: phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
121951926  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121958807  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
121952131  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
121941580  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121953281  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121943028  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121954611  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121958959  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121954358  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121949870  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
121949688  kras; GTPase KRas isoform X1 [KO:K07827]
121956927  zgc:55558 [KO:K07827]
121948777  mrasa; ras-related protein M-Ras [KO:K07831]
121941755  rras2; ras-related protein R-Ras2 [KO:K07830]
121956453  rras; ras-related protein R-Ras [KO:K07830]
121946649  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
121950008  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121938842  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121951784  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
121944320  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121956713  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121953345  hif1aa; hypoxia inducible factor 1 subunit alpha a [KO:K08268]
121942843  hif1al; hypoxia inducible factor 1 subunit alpha, like isoform X1 [KO:K08268]
121958878  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
121954934  DNA damage-inducible transcript 4 protein-like [KO:K08270]
121941791  tsc2; tuberin isoform X1 [KO:K07207]
121959984  tsc1b; TSC complex subunit 1b [KO:K07206]
121959585  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
121954520  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
121959834  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
121951971  rheb; GTP-binding protein Rheb [KO:K07208]
121941941  rptor; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
121955443  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
121946248  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
121946537  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121957065  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
121958732  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
121952739  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
121941910  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
121942813  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
121948129  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
121952873  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121947875  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
121938043  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
121959518  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
121944808  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
121942944  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
121965639  autophagy-related protein 13-like [KO:K08331]
121962723  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
121952655  atg101; autophagy-related protein 101 [KO:K19730]
121950997  rb1cc1; RB1-inducible coiled-coil protein 1 [KO:K17589]
121953264  autophagy-related protein 2 homolog B-like isoform X1 [KO:K17906]
121947846  atg2a; autophagy-related protein 2 homolog A [KO:K17906]
121958608  WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
121956095  wipi2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
121957036  wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
121958860  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
121942887  WD repeat domain phosphoinositide-interacting protein 4-like [KO:K22991]
121942888  WD repeat domain phosphoinositide-interacting protein 4-like [KO:K22991]
121960123  wdr45; LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
121953797  atg9a; LOW QUALITY PROTEIN: autophagy-related protein 9A [KO:K17907]
121951116  atg9b; autophagy-related protein 9B [KO:K17907]
121952382  supt20; transcription factor SPT20 homolog isoform X1 [KO:K21245]
121941636  smcr8b; guanine nucleotide exchange protein smcr8b [KO:K23611]
121956767  smcr8a; guanine nucleotide exchange protein smcr8a [KO:K23611]
121959876  wdr41; WD repeat-containing protein 41 [KO:K23610]
121954018  c9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
121951043  ras-related protein Rab-8A-like [KO:K07901]
121937783  ras-related protein Rab-8A [KO:K07901]
121952496  ras-related protein Rab-39B-like [KO:K07925]
121962353  ras-related protein Rab-39B [KO:K07925]
121957424  rab42a; LOW QUALITY PROTEIN: ras-related protein Rab-42a [KO:K07925]
121947899  sqstm1; sequestosome-1 [KO:K14381]
121961280  tbk1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
121949587  tank; LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator [KO:K12650]
121966118  ras-related protein ORAB-1 [KO:K07874]
121943024  ras-related protein Rab-1B-like [KO:K07874]
121954202  ras-related protein ORAB-1-like [KO:K07874]
121952949  rraga; ras-related GTP-binding protein A [KO:K16185]
121958049  rragcb; ras-related GTP binding Cb [KO:K16186]
121953905  rragd; ras-related GTP-binding protein D [KO:K16186]
121945141  rragca; ras-related GTP binding Ca [KO:K16186]
121951259  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
121940022  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
121959651  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
121959685  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
121966133  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
121941832  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121956428  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
121951289  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
121955918  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
121947706  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
121958808  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
121959676  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121954271  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121951449  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
121946789  bcl2l1; LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
121955462  bcl-2-like protein 1 [KO:K04570]
121963738  bcl-2-like protein 1 [KO:K04570]
121962343  badb; BCL2 associated agonist of cell death b [KO:K02158]
121959158  becn1; beclin-1 [KO:K08334]
121958942  nrbf2b; nuclear receptor-binding factor 2b [KO:K21246]
121945688  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
121962456  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
121954114  atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
121938078  activating molecule in BECN1-regulated autophagy protein 1-like [KO:K17985]
121946204  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121946764  tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
121941748  si:ch211-260e23.9 [KO:K21247]
121952899  vacuole membrane protein 1-like isoform X1 [KO:K21248]
121943579  vmp1; vacuole membrane protein 1 isoform X1 [KO:K21248]
121946286  stx17; syntaxin-17 [KO:K08491]
121952272  uvrag; UV radiation resistance-associated gene protein [KO:K21249]
121953761  endophilin-B1-like [KO:K11248]
121960641  sh3glb1a; endophilin-B1a [KO:K11248]
121965725  rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
121959560  calcium/calmodulin-dependent protein kinase kinase 2-like [KO:K07359] [EC:2.7.11.17]
121953646  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
121955268  map3k7; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
121942177  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121956272  LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121952371  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121952968  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121944061  dapk1; LOW QUALITY PROTEIN: death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
121950225  dapk2b; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
121951609  dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
121938945  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
121943077  hmgb1b; high mobility group protein B1b [KO:K10802]
121952452  hmgb1a; high mobility group protein B1a [KO:K10802]
121953982  eif2ak3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
121953741  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
121955089  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b isoform X1 [KO:K03237]
121944282  mtmr3; LOW QUALITY PROTEIN: myotubularin-related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
121952229  mtmr14; myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
121953724  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
121943542  si:ch211-11n16.2; zinc finger FYVE domain-containing protein 1 [KO:K17603]
121955650  zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
121946158  atg12; ubiquitin-like protein ATG12 [KO:K08336]
121945615  atg5; autophagy protein 5 [KO:K08339]
121957832  atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
121951649  atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
121962916  atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
121949553  CASP8 and FADD-like apoptosis regulator [KO:K04724]
121947829  rab33ba; RAB33B, member RAS oncogene family a [KO:K07920]
121942456  ras-related protein Rab-33B-like [KO:K07920]
121949294  zgc:101559; ras-related protein Rab-33B-like [KO:K07920]
121961214  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
121949752  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121962303  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
121945307  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121965903  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
121948159  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
121950241  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121964451  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
121941210  atg4b; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
121941372  atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
121942565  atg4da; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
121958503  nbr1a; NBR1 autophagy cargo receptor a [KO:K17987]
121956286  nbr1b; next to BRCA1 gene 1 protein [KO:K17987]
121961598  optn; LOW QUALITY PROTEIN: optineurin [KO:K19946]
121958609  calcoco2; LOW QUALITY PROTEIN: calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
121963666  tax1-binding protein 1 homolog B-like [KO:K21348]
121957943  tax1bp1a; tax1-binding protein 1 homolog A isoform X1 [KO:K21347]
121945463  tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347]
121944302  wdfy3; LOW QUALITY PROTEIN: WD repeat and FYVE domain-containing protein 3 [KO:K22262]
121962389  ubiquitin-60S ribosomal protein L40 [KO:K02927]
121951468  ubiquitin-like [KO:K02927]
121940452  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121954444  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
121940193  polyubiquitin-B [KO:K04551]
121940694  polyubiquitin-B-like [KO:K04551]
121959681  ubc; polyubiquitin-C [KO:K04551]
121938664  polyubiquitin-B-like [KO:K04551]
121944157  snap29; synaptosomal-associated protein 29 [KO:K08509]
121959542  si:ch73-234b20.5; vesicle-associated membrane protein 8 isoform X1 [KO:K08512]
121945038  vamp8; vesicle-associated membrane protein 8 [KO:K08512]
121944988  ykt6; synaptobrevin homolog YKT6 [KO:K08516]
121955385  stx7l; syntaxin-7 [KO:K08488]
121944036  epg5; ectopic P granules protein 5 homolog [KO:K23883]
121958683  plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
121952876  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
121963047  vps16; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
121955639  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
121944920  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
121953600  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
121960859  vps41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
121954331  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
121960778  Golgi reassembly-stacking protein 1-like isoform X1 [KO:K26797]
121949189  Golgi reassembly-stacking protein 2-like isoform X1 [KO:K26797]
121951968  LOW QUALITY PROTEIN: Golgi reassembly-stacking protein 2-like [KO:K26797]
121955052  ras-related protein rab7 [KO:K07897]
121955485  si:dkey-13a21.4; ras-related protein rab7 [KO:K07897]
121955965  ras-related protein rab7-like [KO:K07897]
121947427  lamp1a; lysosome-associated membrane glycoprotein 1a [KO:K06528]
121947669  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
121949022  lamp1b; lysosome-associated membrane glycoprotein 1b [KO:K06528]
121956748  napsa; napsin-A [KO:K01379] [EC:3.4.23.5]
121938483  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
121953491  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
121944058  ctsla; LOW QUALITY PROTEIN: cathepsin La [KO:K01365] [EC:3.4.22.15]
121964108  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
121955592  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
121950719  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
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Int J Biochem Cell Biol 37:2098-114 (2005)
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Regulation mechanisms and signaling pathways of autophagy.
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Annu Rev Genet 43:67-93 (2009)
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An overview of the molecular mechanism of autophagy.
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Curr Top Microbiol Immunol 335:1-32 (2009)
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PMID:20034776
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Yang Z, Klionsky DJ
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Mammalian autophagy: core molecular machinery and signaling regulation.
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Curr Opin Cell Biol 22:124-31 (2010)
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PMID:21187343
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Chen Y, Klionsky DJ
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The regulation of autophagy - unanswered questions.
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J Cell Sci 124:161-70 (2011)
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The role of Atg proteins in autophagosome formation.
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Annu Rev Cell Dev Biol 27:107-32 (2011)
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Autophagy regulation by nutrient signaling.
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Cell Res 24:42-57 (2014)
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Related
pathway
plep04010  MAPK signaling pathway
plep04141  Protein processing in endoplasmic reticulum
plep04142  Lysosome
plep04150  mTOR signaling pathway
plep04910  Insulin signaling pathway
KO pathway
ko04140   
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