Entry Name Axon guidance - Pteronotus mesoamericanus (Parnell's mustached bat)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Pteronotus mesoamericanus (Parnell's mustached bat) [GN:
ppam ]
Gene 129062505 TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
129081146 TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
129075010 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
129069877 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
129070613 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
129075257 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
129074067 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
129068140 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
129086649 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
129069153 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
129083566 myosin regulatory light polypeptide 9-like isoform X1 [KO:K12755 ]
129085990 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
129063880 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 [KO:K24609 ]
129063302 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
129063882 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
129087786 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
129062344 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526 ]
129075843 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
129088306 SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526 ]
129068365 RHOD; rho-related GTP-binding protein RhoD isoform X1 [KO:K07530 ]
129075026 DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
129062638 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
129068934 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
129069869 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
129066548 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
129075675 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
129076577 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
129088291 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
129074969 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
129069407 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
129074590 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related ppam04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
