KEGG   PATHWAY: ppam04010
Entry
ppam04010                   Pathway                                
Name
MAPK signaling pathway - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ppam04010  MAPK signaling pathway
ppam04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129061268  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129061368  PSPN; persephin [KO:K25416]
129061435  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129061529  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
129061554  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129061574  NRTN; neurturin [KO:K25414]
129061773  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
129061885  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
129061886  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
129062187  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
129062278  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
129062352  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
129062360  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
129062396  EFNA3; ephrin-A3 [KO:K05462]
129062397  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
129062534  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129062544  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
129062984  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129063058  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
129063313  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
129063382  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129063396  HGF; hepatocyte growth factor [KO:K05460]
129063699  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
129063758  [KO:K03283]
129063844  RAP1A; ras-related protein Rap-1A [KO:K04353]
129063946  NRAS; GTPase NRas [KO:K07828]
129063964  NGF; beta-nerve growth factor [KO:K02582]
129064043  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
129064044  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
129064045  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
129064047  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
129064134  [KO:K03099]
129064151  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
129064157  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129064258  FGF7; fibroblast growth factor 7 [KO:K04358]
129064688  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129064694  FGF20; fibroblast growth factor 20 [KO:K04358]
129064790  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
129064807  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129064891  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
129064900  VEGFC; vascular endothelial growth factor C [KO:K05449]
129064909  ANGPT2; angiopoietin-2 [KO:K05466]
129064979  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
129064990  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
129065007  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129065030  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
129065223  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129065226  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
129065324  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
129065331  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
129065350  FGF16; fibroblast growth factor 16 [KO:K04358]
129065641  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129065729  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
129065732  FOS; protein c-Fos [KO:K04379]
129065733  PGF; placenta growth factor [KO:K16859]
129065743  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
129065829  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
129065833  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
129065957  MAX; protein max isoform X1 [KO:K04453]
129065988  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
129066003  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
129066034  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129066231  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129066345  FGF18; fibroblast growth factor 18 [KO:K04358]
129066346  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
129066417  CD14; monocyte differentiation antigen CD14 [KO:K04391]
129066457  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
129066477  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
129066549  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129066552  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
129066585  FGF1; fibroblast growth factor 1 [KO:K18496]
129066972  TNF; tumor necrosis factor [KO:K03156]
129066979  [KO:K03283]
129067324  [KO:K03283]
129067363  DAXX; death domain-associated protein 6 [KO:K02308]
129067412  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129067413  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129067470  SRF; serum response factor [KO:K04378]
129067485  VEGFA; vascular endothelial growth factor A [KO:K05448]
129067639  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
129067800  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129067833  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
129068140  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129068292  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
129068299  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129068300  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
129068332  FGF4; fibroblast growth factor 4 [KO:K04358]
129068333  FGF19; fibroblast growth factor 19 [KO:K22603]
129068411  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
129068458  FGF3; fibroblast growth factor 3 [KO:K04358]
129068489  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129068502  INS; insulin [KO:K04526]
129068503  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
129068571  RELA; transcription factor p65 [KO:K04735]
129068574  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
129068602  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
129068603  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
129068614  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129068690  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
129068738  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
129068797  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
129068919  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129068992  STMN1; stathmin [KO:K04381]
129069104  ARTN; artemin isoform X1 [KO:K25415]
129069153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
129069204  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
129069218  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
129069418  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
129069687  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129069755  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129069877  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129069895  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
129069921  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
129070196  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
129070225  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129070226  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
129070227  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
129070228  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
129070245  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
129070273  NF1; neurofibromin isoform X1 [KO:K08052]
129070287  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
129070317  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
129070345  CRK; adapter molecule crk isoform X1 [KO:K04438]
129070500  ANGPT4; angiopoietin-4 [KO:K05467]
129070671  STK4; serine/threonine-protein kinase 4 [KO:K04411]
129070771  JUN; transcription factor Jun [KO:K04448]
129070824  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
129071112  [KO:K05096] [EC:2.7.10.1]
129071250  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
129071284  NTF3; neurotrophin-3 [KO:K04356]
129071314  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
129071330  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
129071377  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129071418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129071577  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
129071749  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
129071792  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
129071959  FGF10; fibroblast growth factor 10 [KO:K04358]
129071974  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
129072109  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129072125  IL1A; interleukin-1 alpha [KO:K04383]
129072126  IL1B; interleukin-1 beta [KO:K04519]
129072290  TP53; cellular tumor antigen p53 [KO:K04451]
129072330  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
129072488  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
129072575  PDGFC; platelet-derived growth factor C [KO:K05450]
129072585  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
129072755  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
129072772  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129072939  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
129072943  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129072973  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
129072985  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
129073033  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129073070  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129073176  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
129073410  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
129073492  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129073524  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
129073529  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129073649  [KO:K04410] [EC:2.7.11.1]
129074223  FGF23; fibroblast growth factor 23 [KO:K22428]
129074224  FGF6; fibroblast growth factor 6 [KO:K04358]
129074255  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
129074256  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
129074330  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
129074364  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
129074368  FLNA; filamin-A isoform X1 [KO:K04437]
129074378  IKBKG; NF-kappa-B essential modulator [KO:K07210]
129074653  RASGRF2; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
129074666  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
129074670  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
129074845  JUND; transcription factor JunD [KO:K04449]
129074873  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
129075010  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129075095  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
129075257  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
129075387  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
129075629  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
129075763  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
129075812  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
129075864  RAP1B; ras-related protein Rap-1b [KO:K07836]
129075884  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
129075936  KITLG; kit ligand isoform X1 [KO:K05461]
129075937  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
129076179  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
129076640  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
129076641  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129076675  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
129076731  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129076792  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
129076934  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
129076969  VEGFD; vascular endothelial growth factor D [KO:K05449]
129077110  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129077222  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129077291  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
129077297  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
129077313  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129077479  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129077631  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
129077640  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
129077642  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
129077831  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
129077836  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129077932  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129077935  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
129078061  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
129078069  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129078155  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129078231  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
129078413  [KO:K04392]
129078555  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129078786  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129079053  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
129079398  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
129079505  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129079528  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
129079661  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
129079846  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
129079880  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
129080087  EFNA2; ephrin-A2 [KO:K05462]
129080142  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
129080218  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
129080370  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
129080456  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129080496  BDNF; brain-derived neurotrophic factor [KO:K04355]
129080543  RRAS2; ras-related protein R-Ras2 [KO:K07830]
129080757  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
129081112  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
129081330  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129081363  TGFA; protransforming growth factor alpha [KO:K08774]
129081462  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
129081518  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
129081583  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
129081584  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
129081585  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
129081586  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
129081899  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129081965  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
129081992  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
129082291  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
129082327  FGF9; fibroblast growth factor 9 [KO:K04358]
129082353  [KO:K03283]
129082381  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
129082621  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
129082745  RELB; transcription factor RelB isoform X1 [KO:K09253]
129082796  FGF21; fibroblast growth factor 21 [KO:K22429]
129082804  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
129082806  RRAS; ras-related protein R-Ras [KO:K07829]
129082874  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
129082927  NTF4; neurotrophin-4 [KO:K12457]
129083074  [KO:K03283]
129083119  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
129083235  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
129083353  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
129083590  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
129083795  HSPB1; heat shock protein beta-1 [KO:K04455]
129083924  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
129084081  MYC; myc proto-oncogene protein [KO:K04377]
129084108  FGF5; fibroblast growth factor 5 [KO:K04358]
129084238  STK3; serine/threonine-protein kinase 3 [KO:K04412]
129084274  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
129084802  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
129084834  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
129084880  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
129084910  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129085015  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129085245  AREG; amphiregulin [KO:K09782]
129085287  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129085322  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129085325  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129085332  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
129085376  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129085414  [KO:K03283]
129085670  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
129085732  [KO:K03283]
129086014  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129086248  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129086337  CRKL; crk-like protein [KO:K04438]
129086451  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
129086480  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
129086587  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129086649  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
129086654  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
129086875  CACNB1; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
129087036  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129087313  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
129087383  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
129087491  EREG; proepiregulin [KO:K09784]
129087549  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
129087590  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129087701  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
129088050  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129088134  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
129088189  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
129088202  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
129088232  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
129088299  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129088320  RASA2; ras GTPase-activating protein 2 [KO:K08053]
129088421  MRAS; ras-related protein M-Ras [KO:K07831]
129088423  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ppam04070  Phosphatidylinositol signaling system
ppam04110  Cell cycle
ppam04115  p53 signaling pathway
ppam04210  Apoptosis
ppam04310  Wnt signaling pathway
ppam04668  TNF signaling pathway
KO pathway
ko04010   

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