KEGG   PATHWAY: sanh04217
Entry
sanh04217                   Pathway                                
Name
Necroptosis - Sinocyclocheilus anshuiensis
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
sanh04217  Necroptosis
sanh04217

Organism
Sinocyclocheilus anshuiensis [GN:sanh]
Gene
107694347  tumor necrosis factor-like [KO:K03156]
107678132  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
107685522  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
107671968  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
107700380  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107674458  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
107697985  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
107681247  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107684359  traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
107654304  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107690679  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107698239  TNF receptor-associated factor 5-like [KO:K09849]
107702253  TNF receptor-associated factor 5-like [KO:K09849]
107671717  receptor-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K02861] [EC:2.7.11.1]
107685278  receptor-interacting serine/threonine-protein kinase 1-like [KO:K02861] [EC:2.7.11.1]
107703529  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
107681145  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
107666595  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
107670164  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
107656201  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
107658397  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K10630] [EC:2.3.2.31]
107653168  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K10630] [EC:2.3.2.31]
107653293  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K10630] [EC:2.3.2.31]
107679331  rnf31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
107674392  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
107674166  uncharacterized protein LOC107674166 isoform X1 [KO:K11974] [EC:2.3.2.31]
107662525  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K20894]
107685269  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K20894]
107703612  spermatogenesis-associated protein 2-like [KO:K17595]
107703616  spermatogenesis-associated protein 2-like [KO:K17595]
107681507  uncharacterized protein LOC107681507 isoform X1 [KO:K17595]
107673765  uncharacterized protein LOC107673765 [KO:K17595]
107680738  spermatogenesis-associated protein 2-like [KO:K17595]
107684671  spermatogenesis-associated protein 2-like protein [KO:K17595]
107670151  LOW QUALITY PROTEIN: spermatogenesis-associated protein 2-like protein [KO:K17595]
107698133  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107698139  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107704521  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107696705  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
107655038  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
107692392  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
107657079  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107686825  FAS-associated death domain protein-like [KO:K02373]
107679720  FAS-associated death domain protein-like [KO:K02373]
107660083  caspase-8-like [KO:K04398] [EC:3.4.22.61]
107680357  LOW QUALITY PROTEIN: caspase-8-like [KO:K04398] [EC:3.4.22.61]
107660005  caspase-8-like [KO:K04398] [EC:3.4.22.61]
107688858  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
107688860  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
107672910  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
107660089  caspase-8-like [KO:K04398] [EC:3.4.22.61]
107689487  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
107670339  caspase-8-like [KO:K04398] [EC:3.4.22.61]
107670324  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
107691294  CASP8 and FADD-like apoptosis regulator [KO:K04724]
107689499  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
107695070  CASP8 and FADD-like apoptosis regulator [KO:K04724]
107698141  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
107693415  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
107691306  cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
107695080  cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
107658643  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
107690933  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107654637  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
107684098  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107692674  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
107657058  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107677049  calcium/calmodulin-dependent protein kinase type II delta 1 chain-like [KO:K04515] [EC:2.7.11.17]
107661772  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
107702309  calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
107696884  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107666428  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
107698678  calcium/calmodulin-dependent protein kinase type II delta 1 chain-like [KO:K04515] [EC:2.7.11.17]
107703083  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
107696072  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107662090  ADP/ATP translocase 2-like [KO:K05863]
107702905  ADP/ATP translocase 2-like isoform X1 [KO:K05863]
107695486  ADP/ATP translocase 1-like [KO:K05863]
107656452  ADP/ATP translocase 1 [KO:K05863]
107665435  ADP/ATP translocase 3-like [KO:K05863]
107658113  ADP/ATP translocase 3 [KO:K05863]
107680642  peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
107661686  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
107692970  voltage-dependent anion-selective channel protein 1-like isoform X1 [KO:K05862]
107678579  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
107657206  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
107659642  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
107676431  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
107690181  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
107704122  voltage-dependent anion-selective channel protein 2-like [KO:K15041]
107671013  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
107665798  voltage-dependent anion-selective channel protein 2-like [KO:K15041]
107666407  glutamate dehydrogenase, mitochondrial isoform X1 [KO:K00261] [EC:1.4.1.3]
107696868  glutamate dehydrogenase, mitochondrial-like [KO:K00261] [EC:1.4.1.3]
107698813  glutamate dehydrogenase, mitochondrial [KO:K00261] [EC:1.4.1.3]
107700126  glutamate dehydrogenase, mitochondrial-like [KO:K00261] [EC:1.4.1.3]
107660462  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
107662860  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
107677515  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
107677524  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
107692327  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
107700548  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
107704001  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
107701539  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
107683467  glycogen phosphorylase, liver form-like [KO:K00688] [EC:2.4.1.1]
107693760  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
107671137  glycogen phosphorylase, brain form-like [KO:K00688] [EC:2.4.1.1]
107691963  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
107663289  glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
107684721  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
107701924  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
107662288  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107673914  mitogen-activated protein kinase 8A isoform X1 [KO:K04440] [EC:2.7.11.24]
107667593  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107673832  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107693656  mitogen-activated protein kinase 8B-like [KO:K04440] [EC:2.7.11.24]
107668799  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107653969  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107664647  ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
107658478  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
107658479  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
107658480  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
107678538  ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
107662273  ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
107701055  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
107693507  ferritin, middle subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]
107693508  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
107685196  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
107669050  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
107698318  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
107701849  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
107701850  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
107701851  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
107701853  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
107656596  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
107696149  cytosolic phospholipase A2-like isoform X1 [KO:K16342] [EC:3.1.1.4]
107693742  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
107689769  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
107689812  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
107677770  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
107654280  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
107664433  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107659327  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
107679188  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107657473  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107655377  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
107676389  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107693804  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107703864  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107662629  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107679193  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107659324  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107659328  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107655374  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107655376  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107655378  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107676365  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107655329  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107685009  smpd1; LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
107701086  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
107698231  mlkl; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
107672628  serine/threonine-protein phosphatase PGAM5, mitochondrial-like isoform X1 [KO:K15637] [EC:3.1.3.16]
107684980  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
107661477  LOW QUALITY PROTEIN: dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
107678420  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
107678274  dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
107665195  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
107660516  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
107685954  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
107678967  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
107683527  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
107666787  caspase-13-like [KO:K01370] [EC:3.4.22.36]
107679276  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
107685936  caspase-1-like [KO:K01370] [EC:3.4.22.36]
107659780  caspase-1-A-like isoform X1 [KO:K01370] [EC:3.4.22.36]
107658569  interleukin-1 beta-like [KO:K04519]
107682454  interleukin-1 beta-like [KO:K04519]
107669486  charged multivesicular body protein 2a [KO:K12191]
107666931  charged multivesicular body protein 2a-like [KO:K12191]
107688654  charged multivesicular body protein 2b-like [KO:K12192]
107691601  charged multivesicular body protein 2b [KO:K12192]
107661322  charged multivesicular body protein 2b [KO:K12192]
107654764  charged multivesicular body protein 2b-like isoform X1 [KO:K12192]
107703548  charged multivesicular body protein 3-like [KO:K12193]
107664504  chmp3; charged multivesicular body protein 3 [KO:K12193]
107702881  charged multivesicular body protein 4c-like isoform X1 [KO:K12194]
107666153  charged multivesicular body protein 4b [KO:K12194]
107685807  charged multivesicular body protein 4b-like [KO:K12194]
107691458  charged multivesicular body protein 4c-like [KO:K24782]
107681459  charged multivesicular body protein 4c-like isoform X1 [KO:K24782]
107691553  charged multivesicular body protein 4c [KO:K24782]
107690936  charged multivesicular body protein 6-like [KO:K12195]
107684156  charged multivesicular body protein 6 [KO:K12195]
107672453  charged multivesicular body protein 6-like [KO:K12195]
107671729  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
107681797  vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
107695949  vacuolar protein sorting-associated protein 4A-like [KO:K12196]
107667672  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 4A-like [KO:K12196]
107653644  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
107695432  chmp1a; charged multivesicular body protein 1a [KO:K12197]
107672547  charged multivesicular body protein 1b-like [KO:K12197]
107680401  charged multivesicular body protein 1b [KO:K12197]
107702204  chmp5; charged multivesicular body protein 5 [KO:K12198]
107664100  charged multivesicular body protein 5-like [KO:K12198]
107686086  charged multivesicular body protein 5-like [KO:K12198]
107698119  charged multivesicular body protein 7 [KO:K15053]
107678414  charged multivesicular body protein 7-like isoform X1 [KO:K15053]
107690141  transient receptor potential cation channel subfamily M member 7-like [KO:K04982] [EC:2.7.11.1]
107703936  transient receptor potential cation channel subfamily M member 7-like [KO:K04982] [EC:2.7.11.1]
107653759  high mobility group protein B1-like [KO:K10802]
107704792  hmgb1; high mobility group protein B1 [KO:K10802]
107697437  high mobility group-T protein-like [KO:K10802]
107682836  high mobility group protein B1-like [KO:K10802]
107663625  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
107680360  tumor necrosis factor ligand superfamily member 6-like [KO:K04721]
107685460  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
107659287  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
107673363  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
107686911  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
107669138  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
107658160  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
107670847  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
107689821  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
107662420  interferon alpha-13-like [KO:K05414]
107662421  interferon alpha-13-like [KO:K05414]
107662433  interferon a3-like [KO:K05414]
107683682  interferon alpha-6-like [KO:K05414]
107683686  interferon alpha-13-like [KO:K05414]
107683685  interferon a3-like isoform X1 [KO:K05414]
107653241  uncharacterized protein LOC107653241 isoform X1 [KO:K05131]
107699165  interferon gamma receptor 1-like [KO:K05132]
107681035  interferon gamma receptor 1-like [KO:K05132]
107681036  uncharacterized protein LOC107681036 [KO:K05132]
107699164  interferon gamma receptor 1-like isoform X1 [KO:K05132]
107703709  uncharacterized protein LOC107703709 [KO:K05132]
107700083  uncharacterized protein LOC107700083 [KO:K05133]
107659055  tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
107692376  tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
107671698  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
107681770  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
107699758  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
107672564  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
107694534  jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
107693475  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
107699083  jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
107674650  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
107703360  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
107653597  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
107657528  stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
107687870  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
107660594  signal transducer and activator of transcription 1-like isoform X1 [KO:K11220]
107667368  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11221]
107673542  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221]
107690299  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
107653351  signal transducer and activator of transcription 3-like isoform X1 [KO:K04692]
107657497  signal transducer and activator of transcription 4-like [KO:K11222]
107660593  signal transducer and activator of transcription 4-like [KO:K11222]
107653267  signal transducer and activator of transcription 5B-like [KO:K11224]
107674616  signal transducer and activator of transcription 5B-like [KO:K11224]
107687020  signal transducer and activator of transcription 5B-like [KO:K11224]
107690298  signal transducer and activator of transcription 5B-like [KO:K11224]
107695735  signal transducer and activator of transcription 5B-like [KO:K11225]
107668551  signal transducer and activator of transcription 5B-like [KO:K11225]
107674544  interferon regulatory factor 8-like isoform X1 [KO:K04693]
107689757  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
107690199  toll-like receptor 4 isoform X1 [KO:K10160]
107690165  toll-like receptor 4 [KO:K10160]
107678592  toll-like receptor 4 [KO:K10160]
107678593  toll-like receptor 4 isoform X1 [KO:K10160]
107704493  TIR domain-containing adapter molecule 1-like [KO:K05842]
107702346  toll-like receptor 3 [KO:K05401]
107656973  LOW QUALITY PROTEIN: toll-like receptor 3 [KO:K05401]
107672065  ubiquitin carboxyl-terminal hydrolase 21-like [KO:K21634] [EC:3.4.19.12]
107699606  ubiquitin carboxyl-terminal hydrolase 21-like isoform X1 [KO:K21634] [EC:3.4.19.12]
107676448  sqstm1; sequestosome-1 [KO:K14381]
107663095  sequestosome-1-like isoform X1 [KO:K14381]
107704346  heat shock protein HSP 90-alpha 1-like [KO:K04079]
107704347  heat shock protein HSP 90-alpha 1-like [KO:K04079]
107704376  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
107704377  heat shock protein HSP 90-alpha 1 [KO:K04079]
107704054  heat shock protein HSP 90-beta-like [KO:K04079]
107669433  heat shock protein HSP 90-beta [KO:K04079]
107699163  tumor necrosis factor alpha-induced protein 3-like [KO:K11859] [EC:3.4.19.12]
107681039  tumor necrosis factor alpha-induced protein 3-like [KO:K11859] [EC:3.4.19.12]
107697162  poly [ADP-ribose] polymerase 1-like isoform X1 [KO:K24070] [EC:2.4.2.30]
107678834  poly [ADP-ribose] polymerase 1-like [KO:K24070] [EC:2.4.2.30]
107686821  apoptosis regulator BAX-like [KO:K02159]
107674732  apoptosis regulator BAX-like [KO:K02159]
107679719  apoptosis regulator BAX-like [KO:K02159]
107658432  apoptosis regulator BAX-like [KO:K02159]
107693506  apoptosis regulator BAX-like [KO:K02159]
107654525  apoptosis regulator BAX-like [KO:K02159]
107658414  apoptosis regulator R1-like [KO:K02159]
107658416  uncharacterized protein LOC107658416 [KO:K02159]
107672651  apoptosis-inducing factor 1, mitochondrial-like isoform X1 [KO:K04727] [EC:1.-.-.-]
107680381  apoptosis-inducing factor 1, mitochondrial-like isoform X1 [KO:K04727] [EC:1.-.-.-]
107670385  histone H2A.V-like [KO:K11251]
107682029  histone H2A [KO:K11251]
107691636  histone H2A-like [KO:K11251]
107686736  histone H2A-like [KO:K11251]
107686748  histone H2A-like [KO:K11251]
107677420  histone H2AX [KO:K11251]
107690786  histone H2A-like [KO:K11251]
107690886  histone H2AX-like [KO:K11251]
107668411  histone H2A type 1-C-like [KO:K11251]
107694465  late histone H2A.2.2-like [KO:K11251]
107668744  histone H2A.V isoform X1 [KO:K11251]
107694713  histone H2A-like [KO:K11251]
107699309  core histone macro-H2A.2 [KO:K11251]
107693984  histone H2A-like [KO:K11251]
107693985  histone H2A-like [KO:K11251]
107670793  histone H2A-like [KO:K11251]
107701758  histone H2A-like [KO:K11251]
107658571  histone H2A.V-like [KO:K11251]
107678598  core histone macro-H2A.2-like [KO:K11251]
107668450  core histone macro-H2A.1-like [KO:K11251]
107668451  core histone macro-H2A.1-like [KO:K11251]
107658856  histone H2A.Z [KO:K11251]
107668328  histone H2A-like [KO:K11251]
107694801  histone H2A-like [KO:K11251]
107694833  histone H2A-like [KO:K11251]
107695926  histone H2A-like [KO:K11251]
107676734  histone H2A-like [KO:K11251]
107676739  histone H2A-like [KO:K11251]
107667667  histone H2A-like [KO:K11251]
107667675  histone H2A-like [KO:K11251]
107679959  histone H2A-like [KO:K11251]
107667921  histone H2A-like [KO:K11251]
107667922  histone H2A-like [KO:K11251]
107671220  histone H2A-like [KO:K11251]
107682416  histone H2A.Z-like [KO:K11251]
107654705  histone H2A, sperm-like isoform X1 [KO:K11251]
107656935  histone H2AX-like [KO:K11251]
107704132  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
107691558  peptidyl-prolyl cis-trans isomerase-like isoform X1 [KO:K03767] [EC:5.2.1.8]
107702873  peptidyl-prolyl cis-trans isomerase-like [KO:K03767] [EC:5.2.1.8]
107671740  apoptosis regulator Bcl-2-like [KO:K02161]
107677290  apoptosis regulator Bcl-2-like [KO:K02161]
107697692  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
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Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
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Molecular mechanisms of necroptosis: an ordered cellular explosion.
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Nat Rev Mol Cell Biol 11:700-14 (2010)
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Reference
PMID:26008591
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Regulation of tumour necrosis factor signalling: live or let die.
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Nat Rev Immunol 15:362-74 (2015)
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Reference
PMID:26775689
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Regulated necrosis: disease relevance and therapeutic opportunities.
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Nat Rev Drug Discov 15:348-66 (2016)
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Reference
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Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
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Nat Rev Mol Cell Biol 14:727-36 (2013)
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Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
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F1000Res 4:F1000 Faculty Rev-1297 (2015)
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PMID:24452471
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Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
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Nat Rev Mol Cell Biol 15:135-47 (2014)
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Trends Cell Biol 26:721-32 (2016)
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DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
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Cell 167:1693-1704 (2016)
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Nat Rev Immunol 17:151-164 (2017)
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The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
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Sci Signal 3:re4 (2010)
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Reference
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Many stimuli pull the necrotic trigger, an overview.
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Cell Death Differ 19:75-86 (2012)
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RIP3: a molecular switch for necrosis and inflammation.
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Genes Dev 27:1640-9 (2013)
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Reference
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RIP kinases: key decision makers in cell death and innate immunity.
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Cell Death Differ 22:225-36 (2015)
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PMID:28126382
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Trends Pharmacol Sci 38:202-225 (2017)
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SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
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Cell Rep 16:2271-80 (2016)
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Reference
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Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
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The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
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Dev Cell 37:337-49 (2016)
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Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
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J Biol Chem 285:969-78 (2010)
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Reference
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  Title
The importance of being chaperoned: HSP90 and necroptosis.
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Cell Chem Biol 23:205-7 (2016)
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Reference
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A20 is a regulator of necroptosis.
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Nat Immunol 16:596-7 (2015)
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Reference
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  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
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J Mol Cell Cardiol 103:102-109 (2017)
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Reference
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Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
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Cell Death Differ 16:1419-25 (2009)
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Reference
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Proc Natl Acad Sci U S A 110:E3109-18 (2013)
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NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
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Mol Cell Biol 31:2934-46 (2011)
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Programmed necrosis in microbial pathogenesis.
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Trends Microbiol 22:199-207 (2014)
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BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
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Cell Death Differ 19:245-56 (2012)
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Reference
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Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
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Cell Cycle 9:3166-73 (2010)
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DAI Another Way: Necroptotic Control of Viral Infection.
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Reference
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The diverse role of RIP kinases in necroptosis and inflammation.
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Nat Immunol 16:689-97 (2015)
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Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
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Reference
PMID:28388412
  Authors
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  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
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Reference
PMID:27999433
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Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
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Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
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Reference
PMID:25693118
  Authors
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  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
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Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
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Related
pathway
sanh00250  Alanine, aspartate and glutamate metabolism
sanh04210  Apoptosis
KO pathway
ko04217   
LinkDB

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