Entry Name B cell receptor signaling pathway - Sorex araneus (European shrew)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Sorex araneus (European shrew) [GN:
sara ]
Gene 101553484 LOW QUALITY PROTEIN: uncharacterized protein LOC101553484 [KO:K06856 ]
101546778 LOW QUALITY PROTEIN: putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
101542899 CD79A; B-cell antigen receptor complex-associated protein alpha chain [KO:K06506 ]
101553459 CD79B; B-cell antigen receptor complex-associated protein beta chain [KO:K06507 ]
101546920 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
101554088 PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
101557366 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
101558512 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
101555223 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
101554287 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
101555053 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
101549236 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
101544020 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
101550972 SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099 ]
101545257 CARD11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
101548983 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369 ] [EC:3.4.22.-]
101547106 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
101541868 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
101540938 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101542917 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101556597 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101548304 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101553708 low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560 ]
101542262 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
101542526 LILRB3; leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
101540940 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related sara04610 Complement and coagulation cascades
KO pathway LinkDB All DBs
