KEGG   PATHWAY: sara04810
Entry
sara04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Sorex araneus (European shrew)
Class
Cellular Processes; Cell motility
Pathway map
sara04810  Regulation of actin cytoskeleton
sara04810

Other DBs
GO: 0030036
Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101536910  [KO:K06269] [EC:3.1.3.16]
101536960  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
101536986  NCKAP1L; nck-associated protein 1-like [KO:K05750]
101537005  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
101537046  FGF22; fibroblast growth factor 22 [KO:K04358]
101537119  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101537128  RDX; radixin isoform X1 [KO:K05762]
101537207  MYH9; myosin-9 [KO:K10352]
101537367  [KO:K12757]
101537472  PFN3; profilin-3 [KO:K05759]
101537980  [KO:K12757]
101538246  MYH11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
101538334  MYH10; myosin-10 [KO:K10352]
101538387  BRK1; protein BRICK1 [KO:K05752]
101538408  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
101538700  [KO:K06269] [EC:3.1.3.16]
101538753  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
101538758  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
101538780  WASF2; wiskott-Aldrich syndrome protein family member 2 isoform X1 [KO:K05748]
101538791  PDGFC; platelet-derived growth factor C [KO:K05450]
101538818  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
101538827  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
101538903  FGF23; fibroblast growth factor 23 [KO:K22428]
101538914  C8G; complement component C8 gamma chain [KO:K03999]
101539003  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101539096  CFL1; cofilin-1 [KO:K05765]
101539190  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
101539217  ITGB2; integrin beta-2 [KO:K06464]
101539245  ITGB6; integrin beta-6 [KO:K06589]
101539253  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
101539282  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101539335  ITGA3; integrin alpha-3 [KO:K06482]
101539433  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101539723  BDKRB2; B2 bradykinin receptor [KO:K03916]
101539799  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101539850  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101539889  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101539900  FGF21; fibroblast growth factor 21 [KO:K22429]
101539989  BDKRB1; B1 bradykinin receptor [KO:K03915]
101540263  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101540304  PXN; paxillin [KO:K05760]
101540332  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
101540617  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101540672  FGF8; fibroblast growth factor 8 [KO:K04358]
101540720  ITGB1; integrin beta-1 [KO:K05719]
101540728  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
101540765  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101540938  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101540987  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
101541025  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101541147  KNG1; kininogen-1 [KO:K03898]
101541293  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101541486  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
101541587  [KO:K04371] [EC:2.7.11.24]
101541752  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101541792  EGF; pro-epidermal growth factor [KO:K04357]
101541868  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101541898  ITGAL; integrin alpha-L [KO:K05718]
101541947  C7; complement component C7 [KO:K03996]
101542138  FGF6; fibroblast growth factor 6 [KO:K04358]
101542367  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
101542907  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
101542917  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101542925  ITGB8; integrin beta-8 [KO:K06591]
101542963  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101543016  C9; LOW QUALITY PROTEIN: complement component C9 [KO:K04000]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101543557  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
101543627  MRAS; ras-related protein M-Ras [KO:K07831]
101543637  CRK; adapter molecule crk isoform X1 [KO:K04438]
101543769  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101543883  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101543901  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101543906  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101543935  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101543947  ITGA10; integrin alpha-10 [KO:K06586]
101543972  [KO:K18584]
101544148  ENAH; protein enabled homolog isoform X1 [KO:K05746]
101544191  [KO:K04513]
101544230  F2R; proteinase-activated receptor 1 [KO:K03914]
101544250  FGFR1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
101544296  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
101544698  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
101544896  ITGA9; integrin alpha-9 [KO:K06585]
101544993  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
101545086  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101545097  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
101545115  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
101545195  INS; insulin [KO:K04526]
101545329  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101545446  [KO:K00889] [EC:2.7.1.68]
101545481  FGF10; fibroblast growth factor 10 [KO:K04358]
101545514  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101545833  [KO:K05692]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101545871  MSN; moesin isoform X1 [KO:K05763]
101546118  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
101546136  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101546169  SCIN; adseverin [KO:K05768]
101546238  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
101546263  PFN2; profilin-2 [KO:K05759]
101546501  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
101546644  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
101546702  FGF9; fibroblast growth factor 9 [KO:K04358]
101546777  HRAS; GTPase HRas [KO:K02833]
101546916  ITGAX; integrin alpha-X [KO:K06462]
101546930  RRAS; ras-related protein R-Ras [KO:K07829]
101547014  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
101547021  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
101547060  [KO:K12329]
101547089  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101547106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101547199  ABI2; abl interactor 2 isoform X1 [KO:K05751]
101547238  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101547306  CRKL; crk-like protein [KO:K04438]
101547396  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101547425  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
101547463  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
101547638  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
101547784  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101548002  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101548050  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101548087  ITGB7; integrin beta-7 [KO:K06590]
101548089  ITGA5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
101548090  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
101548208  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
101548304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101548397  PFN4; profilin-4 [KO:K05759]
101548507  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
101548656  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
101548706  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101548998  [KO:K05692]
101549316  DOCK1; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
101549380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101549420  ACTN4; LOW QUALITY PROTEIN: alpha-actinin-4 [KO:K05699]
101549452  ITGB5; integrin beta-5 [KO:K06588]
101549550  C8B; complement component C8 beta chain [KO:K03998]
101549558  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
101549777  FN1; fibronectin [KO:K05717]
101549815  C8A; complement component C8 alpha chain [KO:K03997]
101549928  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
101549936  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
101550252  APC; adenomatous polyposis coli protein [KO:K02085]
101550254  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101550339  FGF16; fibroblast growth factor 16 [KO:K04358]
101550644  ITGA4; integrin alpha-4 [KO:K06483]
101550666  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
101550676  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101550678  ITGA1; integrin alpha-1 [KO:K06480]
101550720  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101550876  ITGAM; integrin alpha-M [KO:K06461]
101550898  MYH14; myosin-14 isoform X1 [KO:K10352]
101550939  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101550952  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101550972  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
101551120  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101551204  C6; complement component C6 [KO:K03995]
101551216  ITGA2; integrin alpha-2 [KO:K06481]
101551269  FAM49B; protein FAM49B isoform X1 [KO:K27976]
101551454  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101551461  [KO:K04526]
101551516  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101551592  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
101551604  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101551709  NCKAP1; LOW QUALITY PROTEIN: nck-associated protein 1 [KO:K05750]
101551817  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
101551840  FGF18; fibroblast growth factor 18 [KO:K04358]
101551866  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101551890  GSN; gelsolin [KO:K05768]
101551892  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
101551907  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
101552061  ITGA2B; integrin alpha-IIb [KO:K06476]
101552106  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101552349  PFN1; profilin-1 [KO:K05759]
101552863  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101552920  FGF5; fibroblast growth factor 5 [KO:K04358]
101552944  EZR; ezrin isoform X1 [KO:K08007]
101552994  FGF20; fibroblast growth factor 20 [KO:K04358]
101553309  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
101553997  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101554147  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101554406  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101554737  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101554820  RGCC; regulator of cell cycle RGCC [KO:K26108]
101554838  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101554839  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
101554996  ITGAE; integrin alpha-E [KO:K06524]
101555057  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101555118  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101555211  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101555290  FGF7; fibroblast growth factor 7 [KO:K04358]
101555310  VCL; LOW QUALITY PROTEIN: vinculin [KO:K05700]
101555319  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101555338  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101555369  FGF2; fibroblast growth factor 2 [KO:K18497]
101555559  CFL2; cofilin-2 [KO:K05765]
101555769  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101555822  TMSB4X; thymosin beta-4 [KO:K05764]
101555975  SPATA13; spermatogenesis-associated protein 13 [KO:K05769]
101556052  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
101556321  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101556597  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101556849  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
101557104  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
101557116  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101557210  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
101557373  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101557482  MYL10; myosin regulatory light chain 10 [KO:K12756]
101557527  [KO:K04513]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101557845  ITGA6; integrin alpha-6 [KO:K06485]
101557998  ITGB4; integrin beta-4 [KO:K06525]
101558008  ITGB3; integrin beta-3 [KO:K06493]
101558259  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101558268  C5; complement C5 [KO:K03994]
101558308  [KO:K00920] [EC:2.7.1.149]
101558430  FAM49A; protein FAM49A [KO:K27976]
101558545  FGF19; fibroblast growth factor 19 [KO:K22603]
101558816  FGF4; fibroblast growth factor 4 [KO:K04358]
101558918  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101558996  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101559038  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101559065  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101559085  FGF3; fibroblast growth factor 3 [KO:K04358]
101559311  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101559343  NRAS; GTPase NRas [KO:K07828]
101559390  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
sara04010  MAPK signaling pathway
sara04510  Focal adhesion
sara04520  Adherens junction
KO pathway
ko04810   

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