KEGG   PATHWAY: sara04010
Entry
sara04010                   Pathway                                
Name
MAPK signaling pathway - Sorex araneus (European shrew)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
sara04010  MAPK signaling pathway
sara04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101536840  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101536977  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101537046  FGF22; fibroblast growth factor 22 [KO:K04358]
101537233  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101537237  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101537598  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101537676  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101537768  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101537991  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
101538128  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101538266  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101538389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101538392  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
101538440  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
101538489  ARRB1; beta-arrestin-1 [KO:K04439]
101538553  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101538572  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101538575  STK3; serine/threonine-protein kinase 3 [KO:K04412]
101538791  PDGFC; platelet-derived growth factor C [KO:K05450]
101538903  FGF23; fibroblast growth factor 23 [KO:K22428]
101538925  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
101538939  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101539018  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101539099  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101539159  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101539181  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
101539272  VEGFC; vascular endothelial growth factor C [KO:K05449]
101539275  EFNA5; ephrin-A5 [KO:K05462]
101539279  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101539336  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101539340  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101539347  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101539433  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101539504  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101539734  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101539738  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101539799  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101539850  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101539892  DAXX; death domain-associated protein 6 [KO:K02308]
101539900  FGF21; fibroblast growth factor 21 [KO:K22429]
101539926  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101540087  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101540263  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101540309  STK4; serine/threonine-protein kinase 4 [KO:K04411]
101540449  KITLG; kit ligand isoform X2 [KO:K05461]
101540472  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101540495  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101540617  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101540672  FGF8; fibroblast growth factor 8 [KO:K04358]
101540816  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101540859  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101540963  [KO:K03283]
101541009  ANGPT4; angiopoietin-4 [KO:K05467]
101541106  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101541161  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
101541261  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101541357  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101541387  MYC; myc proto-oncogene protein [KO:K04377]
101541408  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101541447  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101541530  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101541560  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101541587  [KO:K04371] [EC:2.7.11.24]
101541742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101541792  EGF; pro-epidermal growth factor [KO:K04357]
101541836  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101542138  FGF6; fibroblast growth factor 6 [KO:K04358]
101542224  RELB; transcription factor RelB [KO:K09253]
101542536  NTF4; neurotrophin-4 [KO:K12457]
101542690  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101542881  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101542924  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101543163  RELA; transcription factor p65 [KO:K04735]
101543216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101543220  NTF3; neurotrophin-3 [KO:K04356]
101543247  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101543321  MEF2C; myocyte-specific enhancer factor 2C isoform X2 [KO:K04454]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101543389  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101543461  [KO:K02583]
101543498  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101543585  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X6 [KO:K04373] [EC:2.7.11.1]
101543627  MRAS; ras-related protein M-Ras [KO:K07831]
101543637  CRK; adapter molecule crk isoform X1 [KO:K04438]
101543770  RAP1A; ras-related protein Rap-1A [KO:K04353]
101543875  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101543880  [KO:K04381]
101543883  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101543976  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
101544020  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101544107  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101544171  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101544250  FGFR1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
101544462  EREG; proepiregulin [KO:K09784]
101544502  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101544519  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101544723  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
101544756  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
101544839  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101544856  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
101544873  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101545058  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
101545059  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101545086  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101545195  INS; insulin [KO:K04526]
101545233  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
101545248  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101545287  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101545300  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101545315  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101545321  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101545329  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101545451  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101545481  FGF10; fibroblast growth factor 10 [KO:K04358]
101545629  HSPB1; heat shock protein beta-1 [KO:K04455]
101545641  IGF2; insulin-like growth factor II [KO:K13769]
101545753  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101545755  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101545851  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
101545900  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
101546102  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101546136  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101546274  FLNA; LOW QUALITY PROTEIN: filamin-A [KO:K04437]
101546290  TGFB3; transforming growth factor beta-3 [KO:K13377]
101546311  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101546696  [KO:K04345] [EC:2.7.11.11]
101546702  FGF9; fibroblast growth factor 9 [KO:K04358]
101546777  HRAS; GTPase HRas [KO:K02833]
101546836  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
101546930  RRAS; ras-related protein R-Ras [KO:K07829]
101546946  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101546988  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101547133  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101547149  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101547180  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
101547238  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101547306  CRKL; crk-like protein [KO:K04438]
101547310  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101547411  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
101547499  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101547502  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101547526  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101547575  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101547658  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
101547782  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101547814  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101547933  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101548050  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101548295  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101548424  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
101548477  VEGFA; vascular endothelial growth factor A isoform X3 [KO:K05448]
101548496  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101548664  IL1A; interleukin-1 alpha [KO:K04383]
101548753  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101548881  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
101549049  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101549127  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101549152  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101549172  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
101549191  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
101549205  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101549227  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101549236  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101549242  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101549380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101549580  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101549601  [KO:K03283]
101549691  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101549699  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101549792  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101549935  NRTN; neurturin [KO:K25414]
101549970  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101550002  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101550075  IL1B; interleukin-1 beta [KO:K04519]
101550339  FGF16; fibroblast growth factor 16 [KO:K04358]
101550347  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101550382  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
101550429  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
101550491  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101550676  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101550720  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101550725  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
101550793  JUND; transcription factor jun-D [KO:K04449]
101550947  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101550972  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
101551162  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
101551317  RASA1; ras GTPase-activating protein 1 [KO:K04352]
101551346  TGFB1; transforming growth factor beta-1 [KO:K13375]
101551454  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101551461  [KO:K04526]
101551488  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101551516  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101551580  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101551615  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
101551759  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
101551840  FGF18; fibroblast growth factor 18 [KO:K04358]
101551961  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101552026  FIGF; vascular endothelial growth factor D [KO:K05449]
101552098  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101552208  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101552222  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101552255  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101552331  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101552421  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
101552620  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
101552704  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101552845  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
101552863  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101552920  FGF5; fibroblast growth factor 5 [KO:K04358]
101552966  STMN1; stathmin [KO:K04381]
101552994  FGF20; fibroblast growth factor 20 [KO:K04358]
101553113  PSPN; persephin [KO:K25416]
101553155  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
101553174  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
101553272  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101553316  NF1; neurofibromin [KO:K08052]
101553495  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101553728  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
101553872  TGFA; protransforming growth factor alpha [KO:K08774]
101553959  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101553997  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101554044  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101554147  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101554190  IGF1; insulin-like growth factor I isoform X4 [KO:K05459]
101554287  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101554394  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101554406  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101554515  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
101554595  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101554614  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
101554719  [KO:K04345] [EC:2.7.11.11]
101554854  MAX; protein max [KO:K04453]
101554867  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
101555056  [KO:K05462]
101555057  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101555118  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101555160  [KO:K17534] [EC:2.7.11.25]
101555205  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101555223  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101555290  FGF7; fibroblast growth factor 7 [KO:K04358]
101555338  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101555362  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
101555369  FGF2; fibroblast growth factor 2 [KO:K18497]
101555471  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101555578  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101555656  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101555718  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101555733  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101555769  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101555844  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X3 [KO:K04421] [EC:2.7.11.25]
101555884  SRF; serum response factor [KO:K04378]
101555912  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101555958  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101556018  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
101556063  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556141  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101556557  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556671  ANGPT2; angiopoietin-2 [KO:K05466]
101556741  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101556791  [KO:K04460] [EC:3.1.3.16]
101556800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101556913  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101557114  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101557190  NGF; beta-nerve growth factor [KO:K02582]
101557366  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101557373  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101557523  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101557525  PGF; placenta growth factor [KO:K16859]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101557571  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101557576  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
101557862  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X3 [KO:K04850]
101557916  EFNA1; ephrin-A1 [KO:K05462]
101558045  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
101558512  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101558531  EFNA2; ephrin-A2 [KO:K05462]
101558545  FGF19; fibroblast growth factor 19 [KO:K22603]
101558664  TNF; tumor necrosis factor [KO:K03156]
101558816  FGF4; fibroblast growth factor 4 [KO:K04358]
101558845  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
101558905  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
101558911  AREG; amphiregulin [KO:K09782]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101559028  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
101559083  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
101559085  FGF3; fibroblast growth factor 3 [KO:K04358]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101559343  NRAS; GTPase NRas [KO:K07828]
101559348  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
101559360  [KO:K04424] [EC:2.7.11.25]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
sara04070  Phosphatidylinositol signaling system
sara04110  Cell cycle
sara04115  p53 signaling pathway
sara04210  Apoptosis
sara04310  Wnt signaling pathway
sara04668  TNF signaling pathway
KO pathway
ko04010   

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